Curious who here has run any of these mitochondrial and longevity compounds. NAD+, MOTS-C, Epitalon, SS-31, NMN, NR, any of them. What did you feel, would you run it again, and what would you do different?
At 35 or so depending on your lifestyle and habits your body starts yelling for help or it thanks you if you have got here you probably know what I mean. Recovery takes longer. Sleep feels less restorative. Muscle comes slower and goes faster. Energy is not what it was. Or completely opposite if you did things rite. These are not random shifts. They are biological changes that get better or worse in your 40s if you ignore them.
Here's a few things that help.
The foundation
Nothing else works well on top of a broken foundation. Get these right first.
Sleep is where most of the repair happens. Deep sleep is when GH peaks, inflammation clears, and memories consolidate. Consistently poor sleep accelerates every aging marker you care about. 7 to 9 hours, consistent sleep window, dark cool room.
Resistance training preserves muscle mass, bone density, insulin sensitivity, and cognitive function as you age. Zone 2 cardio supports mitochondrial health and cardiovascular function. Both matter. Pick something you will actually stick to.
Diet is less complicated than the internet makes it. High protein to preserve muscle especially when calories are low. Diverse fiber sources to feed the microbiome. Minimize ultra processed food and chronic alcohol. Eat real food most of the time.
Stress matters more at 35 than it did at 25. Chronically elevated cortisol accelerates cellular aging, tanks testosterone, disrupts sleep, and degrades gut health. Whatever manages it for you, make it consistent.
Supplements worth considering
Teas worth adding
Simple and underrated. Some of the most evidence backed longevity compounds come in daily drinks. I personally love tea so thought id throw it in. Ginger tea really sits well with me specially since I had stomach issues once upon a time
Peptides worth looking into if you wanna go this far
Bloodwork
Get a baseline panel before starting anything and recheck every 3 to 6 months. Tracking biomarkers over time tells you what is moving and catches problems before symptoms show up. Drop a comment if you want a full breakdown of what to run and what to look for.
What are you doing differently for longevity now compared to your 20s? Drop it below.
So I did a cycle of Reta and then added tesamorlin and the tesamorlin absolutely shrunk my wait and got me a flatter stomach but then I decided to take a break and it’s been 3 months. I gained most of my weight back but my waist is still smaller than before and I think ost of my weight I gained back in 3 months is muscle.
But I’ve decided to start Reta again and I was thinking should I do another round of tesamorlin or will do hgh still take care of the visceral fat and get my stomach shredded like tesamorlin did?
Looking for experiences with the strongest non-injection appetite suppression / weight-loss compounds currently being used.
Main priorities:
- strong appetite suppression
- stimulant/focus effects are a plus
- oral only (don’t love injections)
- interested in both mainstream and research compounds
Currently researching:
- tesofensine
- 5-Amino-1MQ
- oral GLP-1s
- SLU-PP-332
Curious what people here have actually found most effective in real-world use, especially for:
- appetite suppression
- energy/focus
- least miserable side effects
- best stack combinations
Would also appreciate hearing what ended up NOT being worth it.
Is the nasal spray worth doing? I heard it can be 50% less effective than the pin but I'm not interested in regular pinning quite yet.
Hello All,
I have been on Reta since early February- started at 0.3mg.
I am now on 1.5mg every three days
I have had nausea every day 😢
I have had to take Zofran once a day and lots of fresh ginger to get thru the day
Will it ever end 🤦♀️
The latter two seem to be more stable.
Anybody here with actual hands on real life experience?
I have a long list of labs. Contacted about ten so far. Have yet to find one to test HMG.
Have a friend who is having a lot of issues with Adderall, but cannot function in life without it. He has "circulation" issues with long-term Adderall. Thoughts on Semax and Selank? Any suggestions from your experiences are most welcome.
Most injection pain is not the compound its almost always the technique here's a few pointers that you may or may not know
picking the rite needle gauge
29 to 31 gauge is the standard range for SubQ peptide injections my personal sweet spot is 31 gauge for belly and thigh shots less pain, still plenty of control but everybody is different and everybody tolerates things differently so find what works for you.
Keep in mind before you go too thin though the finer the needle the easier it bends or folds, especially if you hit resistance and the thinner the gauge the less you can draw up at once. Thicker gauge lets you pull more volume faster. Thinner is more comfortable going in but has its own tradeoffs.
Half inch length is standard for SubQ going deeper than that is not adding anything except more discomfort.
Injection site
Belly fat is the easiest for most people stay at least two inches away from the belly button. Thigh and love handle fat work too rotate every time pinning the same spot over and over causes tissue buildup and soreness that compounds over time. If a spot is bruised or still sore from last time skip it
Let the solution warm up first
Such a simple mistake but easy fix cold solution straight from the fridge stings going in pull the syringe and let it sit at room temperature for a few minutes before you inject simple but it helps.
Slow down on the plunger
Pushing too fast creates pressure under the skin and that burning sensation is can be a results of this mistake. Take five to ten seconds to push the full volume in the difference between fast and slow is noticeable.
Air bubbles
Flick the syringe and push the plunger slightly until any air comes out before injecting. Not dangerous but uncomfortable if you skip it not gonna be the end of the world though I know there is almost always some
Pinching technique
Pinch a fold of skin and go in at a 45 degree angle pull the needle out before you release the pinch letting go first causes more bruising than needed.
GHK-Cu is going to sting regardless
The sting with GHK-Cu is from the copper content not from anything you are doing wrong. Fatty areas help minimize it but some sting is just part of running it. Normal you can add extra bac water if you want it kinda helps
was scrolling through PubMed on a Friday night like the nerd I am and found a post-hoc analysis of SURMOUNT-1 looking at liver fat. They did MRI-PDFF on a bunch of participants with NAFLD at baseline. Fancy MRI that actually measures fat percentage in your liver. The numbers are wild honestly. People on tirzepatide 10mg or 15mg had relative liver fat reductions of around 70%. Over 90% of people on the 15mg dose got down to normal liver fat levels (<5%). Ninety percent.
My hepatologist has been watching my liver enzymes for years. ALT used to be 85. Now it's 22. She kept saying "keep doing what you're doing" but never explained that my liver might actually be healing, not just getting less inflamed. I asked her about this at my last appointment. She said yeah, the imaging studies are showing actual regression of fibrosis in some patients. Not just less fat, but less scarring. I've been on Mounjaro for a year and apparently my liver is reversing decades of damage Wild.
First time posting ever without shirt on😳
1.5 year progress
5’10 200 currently starting weight 242lbs
Currently trt 175weekly for a year, 8th week on Reta
2mg weekly
When do you think I will get better abs?
one of the most effective compounds in the GH and IGF axis category when used right. Recovery speed, muscle repair, tissue regeneration it delivers but the room for error is smaller than most peptides IGF-1 activates some of the same glucose lowering pathways as insulin which means hypoglycemia is a risk mid session if you are not prepared fast acting carbs on hand are not optional the cancer concern is also worth noting IGF-1 is a mitogenic signal that tells cells to grow and divide, which is great for muscle but not if there is anything abnormal already in the body don't even bother specially stop for anyone with a cancer history standard protocol is 10 days max for a reason receptor desensitization kicks in fast and longer cycles stop producing returns. Works well for experienced people who run it correctly. Not a beginner compound
I really wanna hear experiences from this community so drop them in the comments!
How can I lower my e2 ? I already lift eat healthy etc
Could be something you keep seeing come up but cannot find solid info on. Something you are thinking about running but still have questions on or just something you read about and want to understand better.
Drop it below. Either I will cover it in an upcoming post or someone in here who has actually ran it can give you a real answer.
Been wanting to try this stack adamax is basically semax but it last longer like 6 to 8 hours per dose instead of an hour p21 hits BDNF from a different angle so stacking them kinda made sense to me.
What I ran
Not gonna lie first week I took it later in the day than I should have and could not sleep after that I kept it strictly morning
What I noticed week by week
Week one felt just kinda less scattered and easier to lock in on stuff
Week two started feeling more not like a stimulant just more mental stamina throughout the day less friction.
Week three and four were pretty consistent dose in the morning and it carried through most of the day the thing I kept noticing most was recall like I was holding onto details way better than what I normally do
My thoughts
It is not gonna hit you like a stimulant it is more like things just flow easier and you kinda realize it at the end of the day when you look back at what you got done.
| Adamax | P21 | |
|---|---|---|
| Mechanism | MC4R activation, BDNF, TrkB sensitization | CNTF receptor, BDNF transcription |
| Route | Intranasal | SubQ |
| Dose | 300mcg daily | 300mcg daily |
| Timing | Morning only — do not dose late | Morning |
| Cycle | 4 to 8 weeks on / 2 weeks off | 4 to 8 weeks on / 2 weeks off |
| Side effects | Insomnia if dosed late | Very mild, clean profile |
Anyone here try these at all?
I read it was made at Washington State University and it can help from bad drug use that may have damaged the brain or probably even athletes who experienced some kind of brain damage but that’s pretty much all I know going in.
Who has tried it and what was your experience? Good, bad, worth it, not worth it?
Is chasing higher IGF-1 numbers like maxing it out is the goal good or a bad thing or does it start working against you at some point?