r/Finasteride_Syndrome

Been taking DHT blocker saw palmetto every day for 4-5 years, no issue and achully better errection quality, I decided to randomly stop taking it and 2 weeks later I crashed, my d shrank, shaking, went to A&E hospital cause I was so low and scared, I went back on It for 2 weeks and all my issues went away, I tried to ween off it every two weeks since but on half the dose ( one tab A day ) but too quick and crashed again, my mood is unbearable low an everyday sucks and my dick has zero feeling in the the sensitive parts like its broken, thinking of going back on one a day for a few weeks or two-3 months to stabilise then ween off over the span of many months super slow to give my body time to adapt as it feels like I’m rushing it to quickly With the taper maybe… really weird situation

My ideas are

Dht Cream

Cialis

Dick pump

Specifically, stimulation of the somatosensory cortex and the motor cortex of the legs and hands reduces the general symptoms of PFS/PSSD, including tremors, weakness, and analgesia over the body, as well as taste, smell, and sound perception. It even partially helps with libido and sexual function, to the surprise of my neurologist and me,

as short update at 7 session seems this even somehow affected emotion blunting and anhedonia it also improved quite significantly, for now i continue sessions

i want to mention classical rTMS protocol for depression/ocd did absolutely nothing for me, i did 20 session into DLPFC, nothing changes at all nor better nor worse

update seems like even my personality drug response and emotions slowly coming back online

Melcangi’s mouse experiments use mice that do not actually develop PFS, so they cannot be considered definitive proof of PFS.
I think the research being conducted by the PFS Network could lead to the creation of two different types of mouse models.

The first would be a genetic mouse model based on the variants identified by Tampere University. These mice could be treated with finasteride to determine whether they develop PFS-like symptoms.
The second would be an epigenetic mouse model based on the molecular changes identified by Kiel University. In this model, researchers could induce the same epigenetic alterations found in PFS patients and examine whether the mice develop symptoms consistent with PFS.

The Kiel University approach would be particularly valuable because it could help establish a causal relationship between the epigenetic changes and the disease. This would be a major step toward recognizing PFS as a formally established medical condition.
Epigenome-edited mouse models could also be highly useful for drug discovery and therapeutic development.

The ideal scenario would be to treat the Tampere University genetic mouse model with finasteride, confirm that the mice develop PFS-like symptoms, and then determine whether they also exhibit the same epigenetic changes identified by Kiel University. Researchers could then assess whether these changes lead to the wide range of symptoms observed in PFS patients.

Of course, mice and humans differ substantially in their physiology, so there is no guarantee that these models would fully reproduce the human condition. However, studies involving large numbers of PFS patients take many years to complete, and animal models could provide a much more efficient way to investigate the mechanisms underlying the disorder.

Yesterday I administered 150iu HCG as my first dosage ever. Fast forward to nighttime and I’m undergoing insomnia, night sweats, and some headaches/nausea. I also jacked off once earlier and my libido felt worse. I know that seems pretty quick but I had trouble finishing which is not an issue I’ve really had with PFS. I think my flaccid penis is also a bit numb as well.

My question is do I cut my losses and drop HCG altogether after one dose or give it another go on my next scheduled time for an every other day injection? Not sure if there is an adjustment period for stuff like this where it gets worse before it gets better or if those side effects I mentioned should be a red flag.

Edit: one other noticeable change is my nuts sagged like 2 rocks in an empty sack with PFS but now look more like a normal ballsack? In the sense they’re a bit higher up and my sack looks more normal/less empty.

Another article about Finasteride induced depression, sexual issues, and suicide.

VERY IMPORTANT to note that there is an email address for a journalist looking for stories about Finasteride adverse reactions.

Zoe Hardy: zoe.hardy@dailymail.co.uk

Also, there is the daily mail comment section, get stuck in there if you can lads.

Just wondering if there's any cases where anyone's heart reverts back to normal. I've been dealing with this symptom without medication for over a year now without any progress.

As mentioned on SIDEfxHUB, anyone aware of current progress?

The Milano Project aims to:

- Complete 7 human investigations on PFS and PSSD by the end of 2026

- Identify biomarkers proving the biological basis of these conditions

- Map how finasteride and SSRIs disrupt neurosteroid synthesis, including allopregnanolone

- Build the foundation for human clinical trials in Italy

- Share all data with qualified researchers worldwide

https://sidefxhub.com/milano-study/