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Hello. I made 1 or 2 posts here. I developed prostatitis after 3 days of topical version of this posion. In april it became severe. Its been 10 months and i suffer more than ever. 2 mris showed bilateral proatitis in perpiheral zone. My pain is unbearable. I thing my time has come, i cant see any way out. I dont think rhat something able to help me exists. I ve been fighring hard, like a real warrior. But i cant take it anymore. I think i'll be gone in few days, maybe weeks. Please remember me, even though i comnrributes absolutwly nothing in this group. Bye. Wish me a peaceful journey
So yesterday I took my first injection of allopregnanolone caproate (at 10mg). And yesterday I was very, very depressed because of PFS obviously but also because of some other things happening in my life (and probably because I unfortunately had to take quetiapine to sleep). And this was actually good because then I could see if the ALLO would indeed work or not.
Within 20-30 minutes after the shot, I started noticing the effects kicking in. And later on I was no longer depressed, my drive for life had comeback, my anxiety was nearly zero. My TMJ disfunction stopped. Everything was better and I was feeling like my older self essentially.
I took the shot during the day because the person who told me about this said that he talked with the sellers and they told him to take at morning time, but my next shot will be at the beginning of the night (for the insomnia), cause I experienced drowsiness and was sleepy until 5 hours after the shot at 2:30pm.
I now need to finish the vial and see how I’ll feel, I think I’ll keep taking 10mg so it can last longer. I’ll be buying more for sure and I’m trying to get access to Zuranolone via importation. I’m also buying Etifoxine (oral neurosteroids booster).
All I can say is that allopregnanolone is a miracle molecule, and to think we blocked this is insane (finasteride is pure poison). I say this because if you research, you’ll see that not only ALLO acts on GABA-A to promote its effects, but it also upregulates and modulates it. This is the opposite of what benzos do, benzos act on GABA-A but downregulate it over time.
This was just the first day and I need to finish the vial to see how I’ll feel afterwards. But maybe because we have PFS we need to be taking this for life or at least for a longer time than the 14 days used in depression. But maybe not cause we have reports of recovery with Etifoxine, GHB, and also Ketamine (although this one does not act on neurosteroids).
When it comes to ALLO medications, we just don’t have many reports/experiences because essentially, for some very suspicious reason, no one can get access to it (but get access to poisons like benzos). Brexanolone (the IV one) for example is approved since 2019, but heavily restricted and overpriced; and now the same is happening with zuranolone (very, very cheap in Japan though as I showed in my last post).
Now almost 24 hours later I’m feeling slightly better than before the shot (less depressed), but we know the official treatment consists of 14 days. This caproate ALLO will last less than that at 10mg (in the website it says 5-30mg per week). So that’s the update for now.
To avoid censorship when it comes to this topic, I decided to start a new sub called PFS_Protocols. You are all very welcome!
Listen, I know everyone here is eager to be fixed, and I am very much eager to be the guy who fixes you. But each setback or failure we have along the way has resulted in learning something, which subsequently has changed our attack plan, labs to order, or revised the model. We're getting somewhere. I wanted relugolix to be the perfect solution for all and not just "some" of this problem (various people on the drug right now are improved from it, but so are some people from CDG, that aspect of the model [metabolic pileup] appears to be right, but the model is still only partially complete).
As of this moment, I am absolutely certain that my PFS disease model is not perfect, but its insanely better than anything that has ever previously existed, and this case here is about the most perfect example of it that I think I could ever come up with to show you.
Sommer asked for my help on this case. Sommer is not as good as me at treating PFS yet. She is however probably the 2nd best at treating it! She often consults with me on difficult or refractory cases or when the labs are bonkers.
This case is a particularly good one, as it occured from only TOPICAL exposure, which is something that I have been seeking to have examples of to prove when this is all said and done that even a microscopic amount of a 5ARI can push a sensitive system over the edge into catastrophe if they are at baseline, "tickling the dragons tail". This young man was unfortunately propping up his demon core with a screwdriver, and a little topical fin was all it took to pull out the screwdriver and go critical.
I'm sharing his case not asking for input or guidance or anything, I already told Sommer what I think our best course of action is for him, but more like a "Will you look at this insane shit?" banner that you can use to link to someone who doesn't believe you when you tell them these disorders are 100% real, and not "Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic Illness?"
Will you just gaze here upon the absurdity of this man's labs.
Case Presentation:
"The 22 year old male patient began topical finasteride in November 2023 at 0.25 mg nightly (the sum topical exposure is the volume of liquid x drug concentration). Approximately eight hours after the first dose, he awoke with diffuse flu-like body aches, testicular discomfort, and voice cracking; these symptoms subsequently resolved on their own completely. He later restarted at 0.5 mg and experienced similar symptoms with new-onset depression, anhedonia, and brain fog. Over approximately one month, he intermittently stopped and restarted finasteride at progressively lower doses before discontinuing it completely. During this period, he developed absent libido, hard-flaccid symptoms, genital pain, and unusually stretchy skin. Although he remained able to attend school and maintain his social life, his symptoms gradually improved after discontinuation.
He subsequently however developed atopic keratoconjunctivitis and was treated with steroids. Within several days, he experienced a recurrence of flu-like symptoms and stretchy skin, along with tingling, numbness, and an abrupt generalized loss of muscle tone. This created difficulty balancing treatment of his eye disease against steroid-associated worsening of his PFS symptoms.
A trial of calcium D-glucarate produced a temporary window of improvement but was followed by loose stools and hot flashes.
I will review his test results with Dr. Powers and follow up with the patient by email regarding next steps in treatment."
Okay, lets unpack this.
This guy has almost no urinary T, and almost no urinary 5A or 5B metabolites at all. None. Is that because he has no 5A metabolism? No, not even remotely. His serum DHT is HIGH. He lacks the ability to put these molecules into his urine.
His Progesterone and pregnenolone are BOTH elevated, as well as his 17hydroxyprogesterone, indicating that he's piling up there. He also has an elevated 11DOC. I suspect much of his "skin" issues are tissue specific glucocorticoid buildup problems, disrupting connective tissue remodeling, which is also why he can't do normal nightly maintenance on his cornea.
I am still bewildered by the fact that decades have gone by with dudes suffering from this condition but it wasn't until the kooky and eccentric transgender HRT wizard giant cat bioengineering weeb doctor weirdo looked at it and went WTF?!?!? that this was finally noticed.
HOW WAS THIS NOT NOTICED? LOOK AT HIS LABS! LOOK AT THEM! I HAVE A HUNDRED DIFFERENT PATIENT LABS LIKE THIS!
Merck, how could you do this to people and none of all the brilliant scientists and researchers and pharmacists and people you employ ever foresaw this or even recognized it as it was happening?
BAH!
Anyway, next time some doctor or dimwit or dimwit doctor gives you the side eye when you try and convince them that PFS and PSSD (and other post-drug syndromes I haven't gone as deep into yet) are real, show them this poor young man's labs.
(I'm gonna help Sommer do everything we can to help this kid, obviously, but his labs this morning just made me want to flip a table).
- Dr. Powers
