r/Lymphoma_MD_Answers

▲ 3 r/Lymphoma_MD_Answers+1 crossposts

Anyone with Similar Experience, Post Chemo Abnormal Lymph Node Biopsy

My EOT scan showed 1 lymph node lighting up with 4.1 SUV uptake above liver blood pool.

Asked oncologist for lymph node removal and biopsy. Doc only performed aspiration.

Copying, pasting results below. Oncologist recommended waiting until July PET scan.

I struggle with CPTSD and I'm having a tough time recieving these results. If you'd be willing to share similar experience, I'd be most grateful.

Final Diagnosis

Lymph node, 2R, endobronchial ultrasound-guided fine needle aspiration:

- heterogenous lymphoid population, see microscopic description with comment

- negative for carcinoma

 

Lymph node, 2R, flow cytometric analysis:

- no abnormal B-cell population identified

- no abnormal T-cell population identified

(see flow cytometry summary)

Microscopic Description

Microscopic examination shows a heterogenous lymphoid population. Very rare binucleated cells are present which may be reactive or neoplastic in nature. There is no notable increase in eosinophils. Fine-needle aspiration sampling can not exclude focal involvement by Hodgkin lymphoma in this case. There is insufficient material in the cell block for further studies. If there is significant clinical concern for involvement by classic Hodgkin lymphoma, excisional biopsy is suggested.

Flow Cytometry Summary

COMMENT

Flow cytometric analysis of the tissue specimen shows no abnormal lymphocyte population by immunophenotyping. Clinical correlation is suggested. Flow cytometry may not entirely exclude the presence of a lymphoproliferative disorder.

 

FLOW CYTOMETRIC ANALYSIS

The flow cytometric analysis shows 98% lymphocytes with a viability of 98%. Of the lymphocytes, 9% are B-cells, 86% are T-cells and there are 1% NK cells. The B-cells appear polytypic. T-cells show a CD4:CD8 ratio of 4.3: 1 with no aberrant antigen expression. No significant increase in CD34 positive blasts is seen.

 

Antibodies Tested:

CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD19, CD20, CD22, CD34, CD38, CD45, CD56, sKappa, sLambda

 

MICROSCOPIC

A cytospin preparation shows a heterogeneous population red blood cells, occasional lymphocytes, and monocytes.

CLINICAL HISTORY

The patient has a tissue submitted for flow cytometric analysis.

 

CBC

Order Date: 04/29/26. Actual result date may vary.

CBC W AUTOMATED DIFFERENTIAL

Result

Value

Ref Range

 

WBC

5.24

4.00 - 10.50 x10(9)/L

 

RBC

4.74

4.00 - 5.50 x10(12)/L

 

Hemoglobin

13.3

13.0 - 17.0 gm/dL

 

Hematocrit

42.6

37.0 - 50.0 %

 

MCV

89.9

82.0 - 100.0 fL

 

MCH

28.1

28.0 - 35.0 pg

 

MCHC

31.2

31.0 - 36.5 gm/dL

 

RDW, CV

13.4

11.0 - 14.5 %

 

RDW, SD

44.7

36.0 - 50.0 fL

 

Platelet Count

286

140 - 375 x10(9)/L

 

MPV

9.9

fL

 

Differential result

See Diff Report

 

Order Date: 04/29/26. Actual result date may vary.

WBC DIFF AUTO, 6 PART

Result

Value

Ref Range

 

% Neutrophils

50.7

%

 

% Myeloid Precursors Auto

0.4

%

 

% Lymphocytes

35.7

%

 

% Monocytes

9.0

%

 

% Eosinophils

3.2

%

 

% Basophils

1.0

%

 

# Neutrophils

2.66

1.80 - 8.30 x10(9)/L

 

# Myeloid Precursors Abs Auto

0.02

0.00 - 0.07 x10(9)/L

 

# Lymphocytes

1.87

1.00 - 4.80 x10(9)/L

 

# Monocytes

0.47

0.00 - 0.90 x10(9)/L

 

# Eosinophils

0.17

0.00 - 0.40 x10(9)/L

 

# Basophils

0.05

0.00 - 0.20 x10(9)/L

 

ANC Auto

2.66

1.80 - 8.30 x10(9)/L

Gross Description

A. LYMPH NODE (SPECIFY SITE).

Received in the laboratory are 6 diff-quik stained slides and 6 fixed slides.  Also received with the slides is ~5 mL of clear, colorless, watery, fluid.   All slides and containers are labeled with the patient’s name and HRN. Fixed slides are pap stained. Fluid is processed into cell block.

B. FLOW CYTOMETRY.

Received in a RPMI Tube is a TISSUE sample for flow cytometry. A flow cytometric evaluation is performed.

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u/QuantumBenG — 2 days ago
▲ 17 r/Lymphoma_MD_Answers+3 crossposts

T2-t9 fusion- sjogrens? chyle leak? Lymphoma? Unilateral upper chest stretchmark, waxing and waning facial edema, upper gi distension?

"Ct is normal" can this be because its in lymph pathololgy snd being missed on radiology? My rhuem orderd a neck scan and a lymph node bippsy if any abnormal lymph is seem. But that will take time. Im very unwell. I fear inwont last that long. Er thinks im nutty when i go in there with my hanging lumpy face saying " i dont always look like this and my stomach isnt always this big and tight" All side by sides are within hours apart, no ai no funny angles. I had a very complicated t2-t9 syrgery (12 hours +washou infection). But i also have sjogrens apparently so in concerned for lymphoma as well. More below if interested. Thnx

First, I thought I was having allergic reactions, allergist testing me for mast cell now, but now I see that the fluid is hanging around way too long for it to be allergic reactions as I have stretch marks on the left upper chest (none on right) that are thick and red along with the lumpy face on the left the hanging chin that favors the left. I can grab a real thick piece of hanging skin in the left and close to nothing on thr right when my face is thinner. Numbness what I inhale on the back of my skull numbness on my spine when my surgery was performed. Lymphoma comes to mind cus i wad dx sjogrens and told im at high risk, igg also dropped dramatically within 3 months . In apways hypovolemic and i suspect its worse now as im stuck in bed. I cant see strsight and in not neurologically well. When i fo get up and out as things occasiaknlly clear up ill blakc out repeatedly. Electrolyte abnormalities are common. Protein being high or low is common. Er thinks im a crazy man with a douboe chin as ive been in there 3 times with confusion, lethargy and in abikity to walk. They dont know that im not lying about my dhape changing within hours. They have me marked somehwre as crazy i think. My labs are very derrnaged .high neutrophils, high ebc, high immature granulocytes, hyigh rdw, low sodium, low chloride, high lymph #, plus...low ace, abnomormal csf im a mess...

u/Vegetable-Band9245 — 4 days ago
▲ 11 r/Lymphoma_MD_Answers+1 crossposts

osteoporosis?

Hi, I'm (48F) in remission, 3 months post G-CHOP for follicular that had likely transformed to DLBCL. I just had a DEXA scan and the results look pretty bad. Osteoporosis in my spine and ribs (?), hips have osteopenia, very low muscle mass...chemo put me into menopause as well so I'm sure the loss of estrogen isn't helping things. I'm doing an exercise program through the cancer center so I'm lifting weights twice a week and walk every day. I'm wondering if anyone else had these results, and whether they were put on medication for bone loss. And also, which doctor led this effort? Oncologist? PCP? Obgyn? Thanks!

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u/ilikelanduse — 8 days ago
▲ 7 r/Lymphoma_MD_Answers+1 crossposts

Brukinska

I was diagnosed with SLL (Small Lymphocytic Lymphoma) in October 2023.
I’m pretty sure I had it at least 4-5 years before I was diagnosed, as I had large lymph nodes on my neck for a long time, but just never thought of asking my doctor about them when I had my routine check ups.
After seeing the Oncologist, he was okay with me to “wait & watch” as my lab numbers were on the low end.
Last winter (2025) I was sick quite often with colds & sinus infections that I just couldn’t get rid of.
May 2025 I started on Brunkinska.  After being on Brunkinska, I’ve had amazing results with my lab numbers & MRI.
No serious side effects, just some pinpoint sized red dots (petechiae) on my legs & arms and some occasional bruising.
Since going on Brunkinska almost a year ago, my WBC & Lymphocytes and all lab numbers have been in the normal range since November 2025. My latest (done May 2026) MRI and lab work are looking really good.
Just wondering if anyone that has taken the Brunkinska has stopped using it after their blood work & MRI have improved and if so, what results have you had since going off Brunkinska?
I’m meeting with my oncologist next week & would like to discuss the possibility of stopping the medication, but I’m somewhat hesitant stopping the medication as I do not want my SLL cancer to flare up.

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u/PracticalPerson58 — 8 days ago
▲ 5 r/Lymphoma_MD_Answers+2 crossposts

Help. Zanubrutinib vs Bendamustine and rituximab vs DRC for B cell type Waldenström and indolent lymphoma

Hi everyone,

My mum 70F has been diagnosed with B cell type indolent LPL/marginal lymphoma because her MYD88 has come as negative.
They have said she has waldenstroms (WM).

We’ve seen two doctors both giving different treatment options.
One is saying to go for zanubrutinib as she’s on the older side and there will be side effects to chemo.
The other is saying to go for chemo and if she needs to take Zanubrutinib later if she relapses then she can take it then instead of wearing it off now.

We are extremely conflicted as all of this is like diving into the unknown for us and we have no insight into either of these treatments.

Can anyone advise based on what they know or have been through.

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u/Adorable_Pen_6287 — 9 days ago