r/PeptideNasalSpray

Topical? Intranasal? SubQ?

So I was curious why some peps/aminos need to be SubQ and can't be intranasal or topical. I read it is due to their molecular weight.

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- If under 500 daltons, it can be absorbed well topically.

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- If under 1000 daltons, it can be absorbed by the nasal mucosa (intranasal bioavailability).

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- If over 1000 daltons, it has to be administered subQ.

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I couldn't find a cheat sheet or chart for most peps so I created this one. I am not a scientist so this is for simple and "recreational" reference only.

Feel free to make suggestions on edits. I know I might be missing a few - I just took a vendor's price list and worked with what they had.

I hope it helps some of you who like me, like to know the reasons for things and don't want to look up a pep at a time online.

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There are exceptions and workarounds to make some molecules penetrate where they normally wouldn't, like adding capreatic acid, but it is not as simple as it sounds.

Molecular weight is not the only thing at play. There are other factors, too, but this is a quick reference for the overall rule regarding why intranasal reta wouldn't work, for example.

u/Love_and_Lol — 2 days ago

PT-141 Nasal Spray: Perfecting the Timeline and Dosage for Couples

Male (38yo, 178cm, 86kg) and Female (30s, 158cm,53kg). We’ve been dealing with a low-libido/responsive-desire dynamic in our marriage. Decided to test PT-141 nasal spray to enhance our sexual response and connection.

After three trials, we successfully figured out the exact timeline and dosage to bypass the side effects, leveraging its "delayed onset," "long-lasting residual effects," and "intense mental focus" for an incredible weekend experience. Here is the full report.

### 🧪 Dosage & Protocol
* **Source:** Nasal Spray.
* **Male Dose:** 4 sprays (2 per nostril).
* **Female Dose:** 1.5 to 2 sprays (adjusted based on the environment and specific goals).

### 🕒 Trial Logs & Detailed Timelines
#### Trial 1: Male Solo Test (Work Environment, Female Undosed)
* **16:20 (Pre-dinner):** Male administered 4 sprays on an empty stomach while at the office.
* **T+60~70 mins:** Side effects peaked. Experienced a mild headache, frontal pressure/tightness around the temples, and temporary mild blurry vision. There was some pelvic tightness, but peeing just required a short wait—overall, it was completely manageable and not a major issue.
* **T+80~90 mins:** Blurry vision completely disappeared; headache faded into a mild throbbing/warm pressure. My penis felt distinctly warm and heavy, signaling a deep, pre-arousal engorgement. My nervous system felt highly stimulated, and my mind became exceptionally sharp, clear, and energized.
* **T+3~4 hours (After returning home):** Side effects fully subsided, and the primary effects peaked. Engaged in 30 minutes of intercourse with my partner, which felt incredibly satisfying. The drug massively enhanced tactile sensitivity and the brain's receptivity to pleasure.
* **Female Feedback:** My wife did not take the drug this time. She noted that my erection was exceptionally rigid—so hard that it actually caused her a tiny bit of discomfort initially. She also mentioned that the intensity of my ejaculation made the overall experience highly engaging and noticeable for her.

#### Trial 2: Business Trip & Group Social (Expanding New Experiences, Female Dose: 1.5 Sprays)
* **17:00 (Afternoon):** Male took 4 sprays, female took 1.5 sprays.
* **22:00 (T+5 hours - The Interaction Began):** Side effects for both of us had completely cleared, and my wife's sexual energy and excitement erupted completely.
* **The Experience:** During the social event, my wife completely broke through her usual inhibitions. She actively put on a strap-on and intensely took charge with our friend's wife. The most remarkable observation was her incredible level of mental focus—she remained fully locked-in, intensely enjoying and sustaining the sexual activity for over two hours straight, showing immense stamina and an active desire to explore.
* **Female Feedback:** She reported experiencing a bit of nasal congestion and a slight head rush initially, but it cleared up shortly after. Her appetite was completely unaffected, and she slept incredibly well once the night concluded.

#### Trial 3: Couple Home Test (The Weekend Delayed Strategy, Female Dose: 2 Sprays)
We utilized the insights from our previous trials to implement a "spray Saturday afternoon, reap rewards Sunday morning" protocol:
* **Saturday 16:00 (Pre-dinner):** Male took 4 sprays, female took 2 sprays.
* **Saturday 17:15 (T+75 mins):**

* *Male:* Experienced the same frontal temple pressure and brief blurry vision. Pelvic area felt slightly tight, but peeing was not an issue. Distinct warming sensation in the penis.
* *Female:* Side effects were extremely low. By keeping her dose at 2 sprays, she completely avoided any nausea or vomiting.
* **Saturday Evening:** Both of us noticed that we felt sleepy much earlier than usual after spraying. Later in the evening, her responsive desire kicked in heavily; she became extremely affectionate and kept initiating physical touch.
* **Female Feedback:** After giving her a massage, she gave in to the early drowsiness induced by the drug and fell straight asleep. However, waking up the next morning at 09:30 (T+17.5 hours post-spray), the drug was still fully active in our systems. Both of us woke up in a state of spontaneous arousal. Zero warmup or lengthy foreplay was required—we were able to smoothly engage in immediate penetration, enjoying 30 minutes of high-quality intercourse.
* **Male Residual Effects:** My response lasted an incredibly long time. After finishing Sunday morning, I maintained a very strong libido and spontaneous erections throughout the entire day, stretching even into Monday morning. The drug took a full 48 hours to completely clear and quiet down in my system.

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u/milf_rustynail520 — 5 days ago

How to Calculate mcg per Spray for a Peptide Nasal Spray

Decided to post this since I’ve been getting DMs on how to calculate this. The math seems complicated, but the idea is simple:

Total peptide ÷ total sprays = mcg per spray

Simple example

This is the one I always use to explain since it's pretty easy to understand and lots of vials come in 10mg sizes.

Let’s say you have:

  • 10 mg peptide vial
  • 5 mL total liquid (saline preferred)
  • 0.1 mL per spray

First, convert mg to mcg:

10 mg = 10,000 mcg

Then figure out total sprays:

5 mL ÷ 0.1 mL = 50 sprays

Then divide total peptide by total sprays:

10,000 mcg ÷ 50 sprays = 200 mcg per spray

So the answer is:

200 mcg per spray

Common examples using other vial sizes

Assuming 0.1 mL per spray:

Vial size 5 mL liquid 10 mL liquid
5 mg 100 mcg/spray 50 mcg/spray
10 mg 200 mcg/spray 100 mcg/spray
15 mg 300 mcg/spray 150 mcg/spray
20 mg 400 mcg/spray 200 mcg/spray

You can also use a calculator if your vial sizes are different.

Summarized in a picture:

https://preview.redd.it/szsbczcoyg5h1.png?width=1122&format=png&auto=webp&s=f83c1d5eae2b2df374273eac260be3ac6c2872a4

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u/marcus_antonio — 7 days ago
▲ 17 r/PeptideNasalSpray+2 crossposts

Two-ish week Selank nasal spray update (follow up to my 5 day post)

Roughly 2 weeks ago I posted my initial impressions of running Selank intranasally. A few people asked me to circle back once I had more time on it, so here’s my update after taking it for two and a half weeks.

Quick recap of the setup

https://preview.redd.it/5mj5x2s01i4h1.png?width=1074&format=png&auto=webp&s=82afacd3da74ec499ec7efebd23aef2e0505ed1f

Same as before: (10mg vial reconstituted to roughly 200mcg per spray), guide on how I made it here). For the first week, I was doing 200mcg (1 spray) in the morning, with an occasional second spray in the afternoon as needed. During the second week, I upped my dosage to 400mcg (2 sprays) in the morning and another 200mcg (1 spray) in the afternoon if needed. 

Only other pep I’m on is reta at 2mg/week (no changes in dosage or frequency). 

Effects

What changed from week one to week two

First of all, the dosage was pretty much doubled. The first few days felt subtle, almost placebo-like with the exception of the wedding. At the end of the second week the effect is easier to notice. I've read that this is because the physiological benefits of Selank are cumulative. Instead of the traditional anti-anxiety meds which hit hard and make me slightly forgetful and loose, it’s subtle and I have less brain fog.

Mental

The most obvious effect for me is a lower baseline anxiety and my thinking/speaking is more “sharp”. It’s hard for me to describe but it’s similar to the slight lack of inhibition when you’re drunk, it’s just easier to do things without second guessing yourself. In work meetings and social situations, I don’t overthink and don’t have to "plan out" what I’m going to say as much. 

For example, I’m the type of person to type up a whole script to read line-by-line when I have to give a Zoom presentation at work… instead I can just wing it with a few bullet points. My verbal responses also feel quicker when people ask me things. 

Focus

Re: focus, it is definitely not a stimulant and I would not expect it to replace traditional ADHD medicine. There is some benefit, more so that it takes away the overthinking so that it’s easier to actually sit down and start something. (It’s not something that makes you wired and cracked out like high dose caffeine or amphs). I’m going to explore Semax intranasally next to see how it compares.

Sleep

Sleep is slightly better when I take an extra dose in the evening (600mcg total throughout the day). I haven’t tracked this rigorously, but by better I mean sleeping through the night without waking up. Hard to say if this is exactly because of Selank or other factors (different dinner, etc)

The downsides

The noticeably calm feeling of Selank tapers off after a few hours, so if you need all day coverage you will probably have to redose. Fortunately, on the 2 days I skipped, I did not feel a crash, withdrawal, depression, or headaches. As someone who has suffered from benzo dependency and w/d before (extremely hellish - would not wish this on my worst enemy… iykyk), this is a welcome relief. 

Verdict at two weeks

Selank is a keeper in my stack. Once my nasal spray runs out, I will cycle off for a period longer than 2 days (maybe 5 days?) to see if there are any withdrawals and then either run a subq selank cycle or nasal semax cycle. I want to see how subq selank compares to intranasal, but I also want to see what the hype is around Semax for focus.

Happy to answer questions. Will report back soon with either subq selank or nasal semax!

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u/marcus_antonio — 12 days ago

Spray bottles

Have any of you found some awesome
Nasal spray bottles ? I found some
Amber ones on Amazon but they are 10 ml bottles. Problem with such a big bottle is that I always have to tip the bottle when spraying to keep the spray tube full.

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u/kohler1488 — 11 days ago