r/PeptidesScience

I've been dealing with several tendon issues from overtraining for a long time now (triceps, quad, shoulder, distal biceps, pec). Most of them feel more like chronic mild weakness/irritation than sharp pain.
Before my first injury, I was heavily overtraining for around 3 months with poor recovery habits. Since then, I've calmed things down a lot and have spent about the last year and a half trying to recover properly. After calming things down after my first injury (tricep), I was randomly getting weird tendon irritation during lifting from time to time, some lingered like the one above and others went away.
Right now the random irritation stopped but the some irritation is still there (like ones listed above).

I have improved since the first injury, so things are moving in the right direction, but recovery still feels very slow.

I've already been focusing on:
Better sleep
Rehab/loading
Nutrition
Lower training volume (30-60%)

Because progress is slow, I've been researching BPC-157 and TB-500. I know the human research is limited and I'm trying to be cautious.

For people who've actually used them:
Did they genuinely help tendon healing/recovery?
Any side effects or regrets?
Would you recommend continuing natural rehab instead?

Started reta in December at 333 lbs and I’m now 291 in May, so about 42 lbs down. I started extremely low at 0.1mg and slowly titrated up every ~4 weeks. I’m currently at 2.5mg.

The first 3–4 months honestly felt life changing. I had:
- insane energy
- zero food noise
- almost complete loss of body pain/inflammation
- better mood
- more creativity/motivation
- ability to walk/workout daily without it feeling hard

It genuinely felt like my brain and body had turned back on.

But over the last month or two, things shifted a bit. The food noise slowly started creeping back in, some body pain/inflammation returned, and I started feeling more tired, kind of depressed, and mentally “flat.” I also lost that strong motivation/energy boost that made movement feel easy in the beginning.

I increased from 2mg to 2.5mg and the food noise is mostly gone again, but the energy/mental effects never really came back. Now workouts and daily walks feel harder instead of effortless like before.

Has anyone else experienced this after the honeymoon phase? Did your energy eventually come back?

I’m still incredibly grateful for the weight loss and reduction in food obsession, but I miss how GOOD I felt physically and mentally during those first few months.