r/TheeHive

This molecule has been discussed by Shulgin (see here) and some people have reported their experiments with adding 5-MeO-DMT to mushroom growth medium. I thought I'd share a psilomethoxin SAR comparison with similar drugs.

4-MPO a new research chemical stimulant has appeared in the Netherlands (stimulant for European scene). there are no triprepots out there yet.. theoretically (only theoretically on paper) it should be a warmer/softer/more empathogenic analogue of the German 3-FPO which is a harsher analogue of Ritalin (methylphenidate),

and this 4MPO should also affect serotonin (ie act as SNDRI).

there is no image of the molecule structure available, nor anything, just the chemical name: 5-[(4-methylphenyl)(piperidin-2-yl)methyl]-3-methyl-1,2,4-oxadiazole - so I decided to translate it into Smiles code and Smiles code into structure. and check quic structure activity relation ship analysis with basic tools

here is output from PASS online prediction Structure Activity Relationship tool by way2drugs https://pastebin.com/FB2WX9Dj - The substance will probably have affinity as SNDRI - all monoamine transporters are included, it will also act through nicotinic receptors and do something with vitamin B3. Cocaine dependency treatment is also predicted there..

here is output from tool caled swissADME report https://ctrlv.link/AysT - we see that the substance passes through the blood-brain barrier and through the intestinal membrane. the substance is a substrate of g-glycoprotein which can cause the substance to be in the brain for a shorter time or a larger dose will be needed. predicted lipophilicity is optimal (2.84 which is considered optimal) - TPSA(polarity) also shows favorable results and is 50.95 Ų. - must always be below 90.Lipinski, Ghose, Veber, Egan, Muegge: The substance meets all these rules for "medicinal". This means that in terms of size, lipophilicity and polarity it behaves similarly to common pharmaceuticals.from the point of view of computer prediction this substance has ideal parameters to behave as a psychoactive substance acting on the central nervous system (high absorption, ability to pass through the blood-brain barrier, suitable physical properties).

here is report from SAR tool swistargetprediction - : https://ctrlv.link/5DLQ We can see that based on the similarity, the reuptake of dopamine, noradrenaline and serotonin should be blocked, basically this was confirmed by the pass, which is more detailed in this. it also has some epigenetic targets - but they seem to be minor, I'm not an expert on that

It's a new substance, write if someone will "research" it.

here is smiles Cc1ccc(C(C2CCCCN2)c3nc(C)no3)cc1

The substance bypasses blanket bans because it is not an amphetamine or cathinone, it is another attempt to get to the level of the RC stim scene before the ban in the Netherlands in 2025

3FPO (DE nps) was quite popular in Germany (despite the fact that it was more expensive than fishscale cocaine) - It could be an interesting substance.

Anyone who has access to advanced SAR tools would be happy to analyze

Bonus points to the busy bee that randomly guesses that white powder (the organic chemist’s favorite pastime)

I made this one myself a couple days ago from 3,4,5 trimethoxy benzaldehyde

:3