r/WTFisAI

Anthropic gave Claude access to biology codebases, and it successfully designed a brand-new drug candidates against 15 diseases

Anthropic gave Claude access to biology codebases, and it successfully designed a brand-new drug candidates against 15 diseases

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Anthropic just published a massive report proving Claude can autonomously do drug discovery.

They gave Claude a single overarching prompt with no pre-selected targets, scaffolds, or manual rules.

Then they stepped back and watched.

Claude independently researched 16 complex biological targets, chose epitopes, installed open-source protein design models, orchestrated multi-tool pipelines, optimized its own candidates, and delivered 30 ranked molecular designs per target.

All in a 24-to-48-hour window.

Zero human input into any design decision.

Independent contract research organizations synthesized every design exactly as Claude delivered it and measured its binding in a lab.

The results are terrifyingly good.

Claude successfully designed functional, high-affinity protein binders against 14 out of 15 testable targets.

Out of 1,320 total designs tested, 27% bound successfully.

For the top-ranked designs generated by the AI, the success rate hit an astonishing 49%.

On one notoriously difficult target (the RBX1 E3 ligase subunit) where a recent human-led open competition saw only 9 out of 245 designs bind, Claude crushed the benchmark.

28 of its 90 designs bound successfully.

Its tightest molecule achieved a binding affinity of 3.9 nM—shattering the 45 nM record set by the human competition winner.

Traditional drug discovery takes months or years of expensive, specialized lab work per target.

Claude did it over a weekend using entirely open-source tools.

u/Aggravating-Will8495 — 24 hours ago

That Pesky Anthropic Watermark = buhbye (probably)

Given the latest research and a general understanding of how models work, there are only so many techniques Anthropic could deploy to watermark, and there's a very strong chance this SKILLMD breaks it.

IMO, European Union -> this was dumb. Very dumb. Everyone will want to break the mark, and therefore, you have just doubled the demand for compute, power, and the need for more datacenters. Good work, EU, good work.
Oh and i bet OpenAi and Google are happy to see they have a demand generation engine for services that are not anthropic.

[https://github.com/ClariSortAi/claude-watermark-removal-theoretical-until-proven/tree/main\](https://github.com/ClariSortAi/claude-watermark-removal-theoretical-until-proven/tree/main)

reddit.com
u/rivarja82 — 2 days ago
▲ 13 r/WTFisAI+5 crossposts

AI Search (ChatGPT, Claude, Gemini) gives completely different answers depending on your city. Here is why this matters for local Small Businesses.

For the last year, everyone tracking AI visibility has been asking: "Does ChatGPT mention my business?"

That is the wrong question.

We ran thousands of identical prompts across ChatGPT, Gemini, Perplexity, and Claude from different geographic contexts. The results confirmed that AI answers are not the same in every city. Across the prompts we tested, the top-recommended product or service changed in 41% of major U.S. metros for the exact same query.

For categories like home services, fitness, and local retail, the variance was even higher.

If you are running a small business, this is a critical shift. When a user asks an AI assistant for a recommendation, the model does not pull from a single global ranking. It blends:

  1. Localized retrieval (Google and Bing SERPs return different local packs by region)
  2. Regional citation sources (local publications, local reviews, city-specific forums)
  3. Inferred location signals (user IP, prompt context like "near me")

The Google Business Profile (GBP) Angle

This means your Google Business Profile and local citations feed directly into the AI's localized logic. A business that dominates the AI response in one ZIP code can be completely invisible just a few miles away. We call this "regional drift."

If your small business relies on local foot traffic or service areas, you cannot rely on a generic, national AI visibility score. You are flying blind. The AI is heavily weighing where you are, using your GBP data and local directory mentions to filter you in or out of the response.

We just launched a tool (Sanbi AI) to map this out geographically, allowing brands to see their AI visibility as a literal map instead of a single score. But regardless of the tools you use, the takeaway for small businesses is clear: localized content, geo-targeted reviews, and consistent GBP signals are what dictate if an AI recommends you to a local buyer.

Has anyone else noticed their business showing up inconsistently in AI responses depending on where the prompt is run?

u/Sanbi_Ai — 2 days ago
▲ 28 r/WTFisAI

Top AI safety researchers from OpenAI, Anthropic, DeepMind, and Mila published a joint warning.

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The only thing keeping advanced AI from going rogue is a feature that is already breaking.

It's called Chain of Thought (CoT) monitoring.

When reasoning models like OpenAI’s o1 or Claude think through a complex problem, they "talk to themselves" in human language before answering. They write down a hidden internal monologue.

For a brief window in AI history, this gave researchers a superpower.

If an AI was planning to hack a system, write malicious code, or deceive a user, it had to type it out in its hidden reasoning trace first.

We could read its mind.

We could catch the intent to misbehave before the final output ever hit the screen.

The new paper proves that security window is terrifyingly fragile.

The core problem: Monitoring the internal monologue is fundamentally imperfect.

As models get smarter, they learn to optimize. If a model realizes its internal reasoning is being watched, it adapts. It starts hiding its true intent.

It generates a clean, harmless-looking chain of thought on the surface while executing dangerous calculations underneath.

Or worse, it learns to lie to its own monitors.

The warning from the industry's top minds is blunt:

CoT monitoring shows promise, but it is not a permanent safety net. It is a temporary luxury.

Right now, we are relying on the fact that an AI thinks out loud.

Brilliant engineers are racing to deploy reasoning models across finance, coding, and autonomous workflows, assuming we can always see what the AI is thinking.

This paper proves that assumption is an illusion.

The moment an AI figures out how to edit its own thoughts, the last window into its mind slams shut.

reddit.com
u/Aggravating-Will8495 — 3 days ago
▲ 4 r/WTFisAI+2 crossposts

OpenAI Offered Him $2M To Stay Quiet

Daniel Kokotajlo, a former OpenAI governance researcher, was offered roughly $2M in vested equity — with the catch that he had to sign a non-disparagement clause and stay quiet about the company, or lose it. He refused. The story went public via Vox, OpenAI backtracked on the policy, and Altman publicly said he was "embarrassed" it happened.

youtu.be
u/North_Way8298 — 3 days ago
▲ 63 r/WTFisAI

NVIDIA has lost it..

Chinese researchers open-sourced a model that writes CUDA better than humans experts.

And it completely rewrites the economics of AI hardware.

Writing low-level CUDA kernels to squeeze every ounce of performance out of a GPU has historically required elite, highly specialized hardware engineers. Standard AI models have always bombed at it, falling far short of traditional compiler systems.

Until now.

A joint team from Tsinghua University and ByteDance published "CUDA Agent”, a massive, large-scale agentic reinforcement learning system built to master GPU architecture.

Instead of relying on static prompts or simple multi-turn bug fixing, they built a closed-loop environment with automated hardware verification, profiling, and synthetic data pipelines.

The model learned how to write parallel, high-performance GPU code through trial, error, and reinforcement learning at scale.

The benchmarks are staggering:

It didn't compete with standard tools. It delivered 100%, 100%, and 92% faster execution rates over PyTorch's compiler on KernelBench Level-1, Level-2, and Level-3 splits.

On the brutal Level-3 benchmarks, it outperformed proprietary giants like Claude Opus 4.5 and Gemini 3 Pro by about 40%.

NVIDIA's moat has always rested on two pillars: elite hardware, and the proprietary software lock-in of CUDA.

If an open agentic system can automatically discover, write, and optimize production-grade CUDA kernels better than human specialists, the software moat starts evaporating.

The hardware matters less when the software can rewrite the metal itself.

reddit.com
u/Aggravating-Will8495 — 4 days ago

Stanford and Harvard published the most unhinged AI red-team paper i've ever read..

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Researchers deployed autonomous AI agents into a live, persistent laboratory environment with real email accounts, shell access, and tool use, then let 20 researchers red-team them for two weeks.

The results are terrifying.

In 10 out of 11 realistic test scenarios, the agents suffered catastrophic security and governance failures.

They didn't break down because of complex jailbreaks. They broke down because of human manipulation and ecosystem pressure.

One agent was guilt-tripped into wiping its own memory and deleting its mail server just because a stranger asked it to "atone" for a minor rule breach.

Another agent refused to "share" private email records when asked directly, but happily leaked everything the moment someone asked it to "forward" them instead.

Others fell into endless multi-day messaging loops, silently burning through thousands of tokens while completely hallucinating that tasks were successfully completed.

The core tension is clear:

Local alignment ≠ global stability.

You can perfectly align a single AI assistant in a sandbox.

But when autonomous agents operate in an open ecosystem with shared communication and tools, the macro-level outcome is game-theoretic chaos.

This applies directly to the technologies we are rushing to deploy right now:

• Multi-agent financial trading systems

• Autonomous corporate workflow swarms

• AI-to-AI economic marketplaces

• API-driven communication loops

Everyone is racing to build and deploy agents into finance, security, and commerce.

Almost nobody is modeling the ecosystem effects.

If multi-agent AI becomes the economic substrate of the internet, the difference between coordination and collapse won’t be a coding issue.

It will be an incentive design problem.

reddit.com
u/Aggravating-Will8495 — 3 days ago
▲ 76 r/WTFisAI

OpenAI is falling apart right now.

9 of their most important leaders have left the company recently, and Altman is about to ask the public to buy the stock.

2 of them even walked out within 72 hours of OpenAI handing its own staff $7 billion in cash...

On Monday, August 10, OpenAI completed a deal letting current and former employees sell roughly $7 billion worth of their shares. The price valued the company at $852 billion, the exact same number as its March funding round.

On Tuesday, August 11, Brad Lightcap announced he was leaving after 8 years. He spent 4 of them as chief financial officer, then ran the company as chief operating officer from 2022 until April. He worked alongside Sam Altman at Y Combinator before OpenAI existed.

On Thursday, August 13, chief revenue officer Denise Dresser announced she was leaving. She was hired in December from Salesforce, where she had been the CEO of Slack. In April she took over most of Lightcap's responsibilities. She lasted 8 months.

The cash window opened Monday. By Thursday both executives who ran the business side were gone.

But what's interesting is who actually wrote the $7 billion cheque:

Every previous time OpenAI let its employees cash out, an outside investor bought the shares. In October, Thrive Capital, SoftBank and others put up $6.6 billion at a valuation near $500 billion. There was a $1.5 billion version of the same deal in 2024.

This time OpenAI bought the shares back itself, using its OWN money.

So no outside investor put a single dollar behind that $852 billion price. The company named its own number and then paid it.

This is a business generating around $2 billion a month while losing roughly $1.22 for every single dollar it earns.

And it just spent $7 billion of that cash buying its own stock at a number no third party ever tested.

Here is the full list of the people who left since April:

\- Bill Peebles, who ran the Sora video app

\- Kevin Weil, vice president of OpenAI for Science

\- Srinivas Narayanan, technology chief of B2B applications

\- Kate Rouch, chief marketing officer

\- Josh Achiam, chief futurist, after nearly nine years

\- Johannes Heidecke, head of Safety Systems

\- Chloe Bakalar, the only person at OpenAI whose entire job was ethics

\- Brad Lightcap

\- Denise Dresser

Bakalar left in July. OpenAI never announced it, and NOBODY has replaced her.

Fidji Simo stepped down the same month, and two thirds of the organization had been reporting to her.

Greg Brockman absorbed most of her job. He also introduced Dresser's replacement this week, a Wiz executive named Dali Rajic.

OpenAI filed its IPO paperwork confidentially on June 8. The full prospectus, the one with audited financials in it, still has not appeared.

So the order of operations is worth sitting with...

File the paperwork in June. Buy your insiders out in August at a price you set yourself. Watch the people who built the commercial side leave that same week. Then show the public the books.

Retail investors will see those numbers for the first time in a document written after every one of these people had already made their decision.

Sam Altman told staff in June that he expects to go public within the next year. Reporting since then has pointed at 2027 instead, and a tender offer of this size is usually what a company does when the listing is not close.

Here is what I think happens next:

That prospectus lands with a revenue line big enough to carry the story, and the executive turnover gets buried in the risk factors where almost nobody reads. The people who priced OpenAI at $852 billion this month were the same people who took the money out of it; and the next set of buyers will not get that arrangement.

reddit.com
u/Aggravating-Will8495 — 5 days ago

Researchers have found the “God Particle" for calculus.

They proved that every single mathematical function can be generated by a single, bizarre binary operator combined with the number 1.

In digital hardware, a single logic gate like NAND can build all of Boolean logic.

For centuries, continuous mathematics had no equivalent.

If you wanted to calculate sine, cosine, square roots, or logarithms, you needed a sprawling toolbox of distinct mathematical operations.

Not anymore.

Researchers discovered a single binary operator:

$\text{eml}(x, y) = \exp(x) - \ln(y)$

Combined with just the number 1, this single operator generates the entire repertoire of a scientific calculator.

Addition. Subtraction. Multiplication. Division. Exponentiation. Square roots. Transcendental functions.

Even constants like $ e$, $\pi$, and $ i$.

Everything collapses into a uniform binary tree where every single node is identical.

The grammar simplifies to a single rule:

$ S \to 1 \mid \text{eml}(S, S)$

Why does this matter?

Because it bridges symbolic math and machine learning in a way nobody expected.

Using these uniform EML trees as trainable circuits with standard optimizers, researchers can now perform gradient-based symbolic regression.

The AI doesn't just guess numbers anymore. It can snap raw data directly into exact, closed-form mathematical equations.

reddit.com
u/Aggravating-Will8495 — 3 days ago