r/WanderByJose

Disclaimer: this is just my personal interpretation of the topic based on reading the literature. I try to simplify complex scientific concepts in a way that is accessible and hopefully sparks curiosity. I encourage anyone interested to read the paper directly and explore further research rather than relying on simplified summaries like this. From my understanding of the literature, including these papers:

Soltani-Arabshahi, R., Wong, J. W., Duffy, K. L., & Powell, D. L. (2014). Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation. JAMA Dermatology, 150(1), 68-72. https://doi.org/10.1001/jamadermatol.2013.6955

Gowda, A., Healey, B., Ezaldein, H., & Merati, M. (2021). A systematic review examining the potential adverse effects of microneedling. Journal of Clinical and Aesthetic Dermatology, 14(1), 45-54. https://pmc.ncbi.nlm.nih.gov/articles/PMC7869810/

Rodrigues, M. (2020). [Microneedling with retinoic acid oxidative stress RCT]. PubMed, PMID 32978675. https://pubmed.ncbi.nlm.nih.gov/32978675/

Friedmann, D. P., Mehta, E., Verma, K. K., & Harris, R. (2024). Granulomatous reactions from microneedling: A systematic review of the literature. Dermatologic Surgery, 50(12). https://doi.org/10.1097/dss.0000000000004450

Friedmann, D. P. (2024). Treatment-refractory granulomatous reaction to microneedling with transepidermal drug delivery of vitamin C, niacinamide, and botanical extracts. International Journal of Dermatology. https://doi.org/10.1111/ijd.17542

Crown Aesthetics. (2021). SkinPen Precision instructions for use (PN#P5SP064.00). Crown Aesthetics. https://crownaesthetics.com/wp-content/uploads/2021/04/SkinPen-IFU-User-Manual.pdf

U.S. Food and Drug Administration. (2016). De novo classification request for SkinPen Precision System (DEN160029). FDA. https://www.accessdata.fda.gov/cdrh_docs/reviews/DEN160029.pdf

Note that some of them are under paywall. I have access to them due to my profession. While you cannot access them all, some of them are open-access so you can still contrast great part of the information.