The Incredible Art of D’Lavigne
Just came across the work of D’Lavigne on Insta. Their images epitomise the night feeling in its fullest.
u/WanderByJose — 2 days ago
r/WanderByJose
Topical antioxidant serum + microneedling provides superior outcomes for facial rejuvenation than only microneedling
A 12-week, prospective, randomized, double-blinded, split-face trial was conducted in 31 adults with signs of facial aging. After subjects receiving microneedling treatments on both sides of the face, one side was randomly assigned to receive application of antioxidant serum while the other receiving placebo serum.
At Week 12, the Microneedle + Antioxidant side demonstrated significantly greater improvements in modified Griffith’s scale scores (23.9% vs 6.8%, p<0.001), hemi-MASI scores (31.2% vs 5.1%, p<0.001), and skin elasticity (39.0% vs 6.8%, p<0.001) compared to Microneedle + Placebo.
GAIS assessment revealed 89.3% of antioxidant-treated sides achieved marked/near-total improvement versus 7.1% of placebo-treated sides. The antioxidant-treated sides also demonstrated superior improvements in skin elasticity (39.0% vs 6.8%, p<0.001) and melanin index (21.3% vs 3.4%, p<0.001). Only mild, transient side effects were reported.
Therefore, combining topical antioxidant serum with microneedling provides superior outcomes for facial rejuvenation than microneedling alone. This combination protocol significantly improves clinical signs of photoaging, including skin elasticity, rhytides, and dyspigmentation, suggesting an optimized treatment protocol with minimal recovery time.
Paper: A Double-Blinded, Split-Face Clinical Trial Evaluating the Effects of a Vitamin C, E, and Ferulic Acid Serum Combined with Microneedling on Facial Photoaging: https://www.tandfonline.com/doi/full/10.2147/CCID.S565035#d1e296
u/WanderByJose — 4 days ago
▲ 15 r/WanderByJose
Just had a scalp microneedling session with Jeunetique Exo Hair at 0,75mm
Just had a microneedling session as another preventive measure towards hair loss.
As some of you might know, I had a hair transplant eight and a half years ago. 3500 grafts FUE.
On a daily, I take a prescribed oral capsule with minoxidil and finasteride. That is the most effective treatment that I have experienced and thankfully I have no side effects.
As an extra, I have dermarolled in the past at 0,5mm before getting the derminator and use minoxidil topic at night to boost the effect.
Here, I am introducing Jeunetique Exo Hair, mostly due to its active ingredients: Atelocollagen , Cellular Growth Factors , PDRN (Polydeoxyribonucleotide) , Peptides.
As someone who already lost his hair once and it’s in the extra lap, I have very specific expectations:
- I hope for this product to help me MAINTAIN my hair and extend his lifespan.
- I am grateful for any extra improvement in terms of density and/or thickness of the hair.
What I am not expecting is becoming Just Bieber at 16.
Microneedling itself, at 0,75mm touches the most effective depth for hair regrowth. My medication and Jeunetique Exo Hair will boost the effect of the mechanical puncturing of the microneedling device.
Personally, I do not take before/after photos of anything hair related. It is something that I do to improve my chances but I do not want to direct my attention to that. Too many years worrying about hair loss and I do not want that in my daily life.
So, this is my take on this: I use what I can afford and what is sustainable for me but without focusing too much on the details. I believe the battle to hair loss is a marathon and all I can do is follow the decisions I have taken and trust the process :)
If you have any questions before the video comes out, drop me a message in the comments
I have recorded this session so I hope to publish an episode soon
u/WanderByJose — 9 days ago
▲ 42 r/WanderByJose
An illustrated anatomical approach to reducing vascular risk
Understanding the facial arteries matters because many injectable treatments are not just “beauty actives.” Products such as hyaluronic acid filler, calcium hydroxyapatite, PLLA, PMMA, fat grafting, and some biostimulators or skin boosters, including PN/PDRN-style injectables, are placed into living tissue close to important blood vessels. The highest vascular occlusion risk is usually linked to fillers and thicker or particulate biostimulators, but any injectable placed in the wrong plane, under pressure, or into a vessel can compromise blood flow. That is why a face map is not decoration. It is a safety tool. It helps show where the major arteries run, why certain zones are higher risk, and why anatomy, depth, technique, and professional training matter before injecting anything into the face.
Read more here: https://www.sciencedirect.com/science/article/pii/S2352587822000729
u/WanderByJose — 11 days ago
Microneedling With Exosomes Shows Early Promise Across Multiple Skin Conditions, Systematic Review Finds
Some key takeaways from this systematic review:
1. The evidence is promising, but still early.
The review screened 256 unique references, quality-appraised 10 studies, and included 8 studies with a total of 171 patients. Study sizes were small, ranging from 3 to 60 participants, so this is not yet “strong proof,” but it is a useful early evidence base.
2. Microneedling + exosomes was studied across several targets.
The included studies looked at androgenetic alopecia, skin aging, melasma, hyperpigmentation, enlarged pores, active acne, and atrophic scarring. This supports the idea that exosomes are being explored not just for “glow,” but for regeneration-related concerns: hair density, pigmentation, collagen remodeling, acne marks, scars, and pores.
3. Hair growth data showed a measurable but modest improvement.
In androgenetic alopecia, one 24-week open-label study using freeze-dried exosome solution delivered with microneedling showed hair density increasing from 158.03 hairs/cm² to 166.14 hairs/cm² by week 24, with P < .001. Patient-reported hair thickness improved in 58.62% of patients, and daily hair loss improved in 55.17%.
4. Skin aging results were stronger when exosomes were added to microneedling.
In a split-face trial with 28 patients, exosome + microneedling outperformed saline + microneedling. Wrinkle roughness improved by 12.4% to 14.4% on the exosome side versus 6.6% to 7.1% on the control side. Elasticity improved by +11.3% with exosomes versus −3.3% on control, hydration improved 6.5% versus 4.5%, and pigmentation reduction was 9.9% versus 1%.
5. Histology matters: it was not just visual improvement.
The review reports histological findings showing greater collagen density and new collagen synthesis on the exosome-treated side. Another split-face trial showed increases in collagen I, glycosaminoglycans, and collagen remodeling markers after treatment.
6. Pigmentation results were notable.
In melasma, 88.9% of patients improved from moderate to mild modified Melasma Area and Severity Index scores. Another pigmentation study reported that 58% of patients rated their outcome as “very much improved” and 42% as “much improved.” Objective 3D analysis showed superficial dark spots decreasing from 39.75% to 26.8%, and deep pigmented lesions from 45.33% to 29.42% by week 12.
7. Acne, scars, and pores had interesting signals, but tiny samples.
A 3-patient case series using Lactobacillus-derived exosomes after microneedling reported improvement in acne severity from 3.34 to 1.34, PIH from 12 to 6.67, and scarring from 3.34 to 2.34 at 2 months, with mean satisfaction of 8.6/10. Another 3-patient pore study showed GAIS scores of 4.00 at 12 weeks and 4.32 at 24 weeks.
8. Safety looked good in these studies, but the certainty is limited.
Across the 8 included studies, no patient discontinued because of adverse effects. Reported reactions were mostly temporary: redness, mild swelling, petechiae, tingling, and burning, usually resolving within 24 to 72 hours to 1 week. However, the review also highlights major limitations: small samples, follow-up of 6 months or less, heterogeneous exosome sources, variable protocols, and undisclosed regulatory status for externally sourced products.
u/WanderByJose — 10 days ago
Oubli de désinfecter
J’ai fait mon microneedling j’ai mis de la crème anesthésiante j’ai lavé avec un nettoyant mais j’ai oublié de passer les lingettes désinfectantes sur mon visage je stresse grave là !!!! C’est ma 3eme séance de microneedling et j’ai utilise des aiguilles de 18
u/Ella_92360 — 10 days ago