r/clozapine

I'm diagnosed with schizophrenia, I have only had mild positive symptoms, but overwhelming negative symptoms  and depression. I have tried all antidepressants, a lot of AP's, lithium, ECT. No effect

Now I have been on clozapine for 22 days and I am now on 200 mg and plan to stay there and not increase dose.. It has an effect on my suicidal ideation and i'm a little less depressed, but the side effects started on 200 mg, primarily dizzines, feeling weak, and i don't know if i can live with it, it's really bad.

Do these side effects get less as time  goes by and I adjust to the medicine?

Hey everyone,

My diagnosis is either bipolar with psychotic features or scza-bipolar type (one of the two).

I've been on clozapine for 12 years. I started around 300 or 400 and now down to 175 (all self directed). Have relapsed just a few times, last time was around a year ago maybe a few years ago, don't remember. I am doing stunningly good right now, just a slightly bad sleep schedule.

On supplements now which help so much, helped with my affect and everything.

My last relapsed happened at 150 (it was a fast reduction from 200 to 150 or 175 to 150), and I was not on supplements at the time. I just ordered liquid clozapine for the first time.

Obviously so many details to add, but wondering if there's anyone who tapered down to super low or zero clozapine out there.

I am a basically a health/stabilization expert compared to the average person at this point.

If you don't believe in lifestyle and supplements, don't bother commenting.

Btw, my goal right now is to get down to zero clozapine in two years. Will probably consult a psychiatrist (not my current one), maybe Doerring's TaperClinic.

Anyone do something similar before?

I don't get it and my np doesn't get it either. They lowered my does from 600mg to 300mg. The voices came back after being gone 3 years so they increased it. I've been back at 600mg for 2 weeks so far and I'm hearing whispers sometimes and having weird experiences at church occasionally.

Not sure where to go from here. My np is waiting on my blood work of clozapine and norclozapine levels to come back before she makes her next move.She also referred me out to a psychiatrist.

Anyone getting strepthroat freq on clozapine

I used to take clozapine for 6 years, until 1.5 years ago when my doctor and I decided to stop it. after that, my life has been a huge mess. hospitalization after hospitalization, overdoses, voices, psychotic episodes, depression, hypomania, etc etc. now I'm in the psych hospital once again, and the doctor said he doesn't know what to do with me anymore, so we have to start clozapine again. he did say that it has to be my own decision.

I had time to think. my boyfriend and my mom both say that I should start it. I kinda think the same, but the voices don't like the idea. today I told a nurse that my decision is to start clozapine again. the doctor just came to tell me that we're starting clozapine tonight.

I'm a bit scared though. the weight gain scares me, the tiredness scares me, the drooling, the bloodwork, the heartache, I mean everything scares me. but I don't want to live like this anymore. this is not a life. I want my life back, and if clozapine is the answer, I think I have to go with it.

(English is not my first language)

Ive been on clozapine since September 2025, in the beginning the side effects effects was sedation , drooling and constipation. And also randomly falling and involuntary muscle movement

It wasn’t until February this year I , for the first time in my life I experienced epilepsy, GTK to be exact. First time it lasted 5 minutes, I got a brain scan he neurologist said it wasn’t anything .

Fast forward to mars it happened again first was 20 minutes , the last time happened in april and it lasted for 1 hour. Biting my tongue , peeing myself. I went to the hospital as soon as it happened. Thats when they found out by taking EEG , that it was epilepsy.
I started on 312,5mg I am now on 287,5mg. Tapering of 12,5mg each time.

I haven’t experienced any withdrawal symptoms yet , I take zolpidem for sleep.