r/migrainescience

Wildfire smoke linked to more Emergency room visits for migraine

“Wildfire-sourced fine particulate matter with an aerodynamic diameter of 2.5 μm or less (PM2.5) was associated with a 6% increase in emergency department visits for migraine and headache. There was no significant link between PM2.5 and emergency department visits on nonwildfire days, and the associations were attenuated in the least materially and socially deprived areas.” https://jamanetwork.com/journals/jama/fullarticle/2853042

Particularly interests me as a climate scientist with chronic migraine

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u/when-is-enough — 4 days ago

Olanzapine (aka Zyprexa) May Be Effective for Status Migrainosus

Howdy from one of your new mods!

I have been in status for about a month and my neuro prescribed olanzapine a couple days ago. This inspired me to dig into research a little!

  • Problem: status migrainosus, aka a migraine attack lasting more than 72 hours
  • Home treatment (initiated when typical oral abortives have failed) can include use of neuroleptics like oral metoclorpamide/reglan or oral steroids; injection or nasal triptans, DHE, or ketoralac/toradol
  • ER treatment guidelines suggest IV use of neuroleptics like metoclorpamide/reglan or DHE
  • Refractory cases may consider IV depakote and/or nerve blocks
  • My neuro office typically uses nerve blocks (occipital and/or SPG) and oral steroid tapers for home care when abortives have failed, preferring to keep you out of the ER if possible

Nerve blocks and steroids have failed me in the past, so my neuro suggested a short course of oral depakote (similar to sodium valproate) or oral olanzapine/zyprexa. I opted for olanzapine since both are sedating but the olanzapine you take at night and the depakote is taken multiple times throughout the day. So my hope is that olanzapine will preserve more daytime functionality.

Here's a recent article I found on olanzapine for status:

Efficacy of Olanzapine as an Abortive Treatment for Status Migrainosus: A Retrospective Chart Review
Published in Neurology, April 2025

  • What they did: review hospital records to look at outcomes for individuals who were given olanzapine for status migrainosus. They excluded patients prescribed olanzapine for long-term use or to treat conditions other than status migrainosus
  • What olanzapine is: an atypical antipsychotic drug that blocks dopamine and serotonin receptors. Tpyically used to treat bipolar disorder type 1 and schizophrenia
  • All together, they had 59 patients who met criteria for the ~3 year period they looked at
  • Treatment was effective in 29/42 patients (69%) on 2.5 mg, 10/12 (83%) on 5 mg, and 3/5 (60%) on doses over 5 mg. Overall it was effective in 42/59 (71%) patients -- I am not able to access the full text to see, but I presume this was delivered by IV

So: small observational study, I would give it less weight than a double-blinded, controlled study, but the results are encouraging. It's too soon to tell if it's working for me (25mg 1x daily for 3 days) but I'll update to report. The office protocol can include increasing the dose as high as 75mg if needed to manage attacks and for up to 5 days if needed.

u/hotheadnchickn — 4 days ago

Fascinating read… Deepwater Horizon Oil Spill Coast Guard responders with high self-reported crude oil, dispersant, and exhaust fume exposure more likely to be diagnosed with all type of migraine and headache conditions in 5-year follow-up

Young, active, health coast guard responders were deployed to clean up the 2010 explosion of the offshore oil drilling rig. They were exposed to the crude oil and other chemicals itself, including burning off of the oils, and many other stressors like heat, anxiety, workplace injury, and more. This study looked at each of those stressors and exposures and the health outcomes on over 3,000 of the responders 5 years after clean up of the disaster. I thought the study did an excellent job teasing out all the various exposures and stressors one might have experienced and all the various conditions one could then be diagnosed with. The study has other conclusions as related to other exposures and stressors leading to other diagnoses. Obviously the most pertinent here is the chemical fume exposures being a (significantly significant) risk factor for migraine and headache diagnosis when controlling for other factors.

https://pmc.ncbi.nlm.nih.gov/articles/PMC13469484/

u/when-is-enough — 4 days ago

Digital screen exposure and migraine systemic review and meta-analysis

“Conclusion: Digital screen exposure is associated with approximately 60% greater odds of migraine or headache, with biologically plausible mechanisms but low-certainty evidence drawn almost entirely from cross-sectional studies. Screen exposure should be regarded as a modifiable, clinically assessable factor in migraine care, while prospective, objectively measured, and interventional research is needed to establish causality and to test targeted mitigation strategies.”

https://pubmed.ncbi.nlm.nih.gov/42603831/

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u/when-is-enough — 4 days ago

Migraines changed?

Hi! New here but Google guided me. I've suffered from textbook migraines for 25 years. Head splitting, light and sound sensitivity, nausea, vomiting, etc.

Last October, I had my first migraine with aura (shimmering), I went to the ER because I thought I was having a stroke. MRI showed nothing so doctor said it was an ocular migraine or a silent migraine.

A couple weeks later, I had another one. Visual disturbance, I saw shimmering and once again, thought I was stroking out because the right side of my face got tingly and numb feeling. Another ER visit and MRI again showed nothing.

Then nothing from October until today.

This time, I saw zig zags. It was primarily my left eye but I saw a little on my right side. Left eye spread across my whole vision and right eye stayed small and in peripherals. 15 minutes later its over. I went to the ER again because it was different than last time. They did a CT and said its either another ocular migraine or a TIA and sent me home with a referral to Neuro.

My questions: Why am I suddenly getting migraines with aura? I've never had them before and they are terrifying. Why would my migraines change? I still get the head splitting ones but apparently a random aura one with no pain. Do auras change each time or is it a once you've had that type, you'll get another one? Is it normal to go from sparkles to zig zags? What triggers them? I was just watching TV and it came on.

Sorry for all the questions but I'm anxious while waiting for my appt.

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u/Adcarp2008 — 4 days ago

Looking for a mod (or two). Reply below. I'll message you in around 2 weeks when I have some time as I'm currently inundated with work. Only requirement is at least one comment in this subreddit within the past year. This will also require posting studies so a medical or research background is great

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u/CerebralTorque — 10 days ago
▲ 5 r/migrainescience+1 crossposts

Navigating school

No seeking medical advice—I'd really love to hear from people who actually use triptans or have kids who do.
Yay, we finally found a triptan that works without any scary side effects! Unfortunately, it makes my son fall asleep hardand pretty quickly afterward.
I'm torn about what to do if he gets a migraine at school:
Add the triptan to his IHP so he can take it at school, knowing he'll probably need time to sleep afterward.

If he gets a migraine at school, have him picked up early so he can take the triptan at home and sleep it off.

Keep the school plan as just the potent NSAID + Zofran, then give the triptan after pickup.

Right now his prevention is daily CoQ10. His rescue plan is a potent NSAID, Zofran, and a triptan. The IHP currently only lists the NSAID and Zofran because that's what was in place before we found a triptan that works, but his neurologist said the triptan can be added.
For those of you who get really sleepy from triptans (or have a child who does), how do you handle school? Does the sleepiness lessen over time, or has it stayed about the same?

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u/Serious-Train8000 — 14 days ago