r/researchchemicals

jwh-018 and third gen of noids

If someone addicted to the new generation of cannabinoids like mdmb-pinca and Ab-chiminca ...etc

And turned to jwh018 , will jwh give weak effects? And with new gen cannabinoids tolerated person what the best amount for jwh018 would be effective on the cigarette from one puff. .... The jwh018 is reddish oil here

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u/El-Don2 — 9 hours ago

3-mmc before surgery

Sorry if not allowed but am freaking out a little bit. I have had a massive relapse from 3-mmc (I was 3 months clean) and have consumed a small portion (I think max 1 gram of the 4 in total) in the 30-40 hours before I’ll be admitted. No use after that. I hate myself so much for it.

Will this effect my surgery? It’s a short one, between 30-90 mins ureterorenoscopy for kidney stone removal. But it will be under general anesthesia. Also smoked a little bit from a hasj joint.

I was already really scared to undergo surgery, and now even more so.

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u/Reminiser — 1 day ago

From suicidal RC addict to happy sober man.

Hi i am just a random dude from internet. I don't have lot of friends so i would like to tell my story to you, so to a random dude on internet.

I grew up in a breaking family, divorcing parents, no abuse but physical punishments were there. I felt lonely as a child. I developed anxiety-depressive disorder, among others. When i was 14 my problem with alcohol started. I went to psychiatric hospital 4 or 5 times , one time because of suicide attempt. I went to rehab by court order. I tried xanax and speed during my childhood. When i was 18 i stopped alcohol, however i became addicted to meth. Mdma heavy doses, some weed which i don't like, some lsd, heroin here and then. I was struggling with anxiety all the time, but it got worst after lsd induced psychosis which i felt then like it destroyed my life. I was searching net how to get benzos. I found out about bromazolam. Ordered. Tried. Fuck. Half of a pill felt like ecstasy because it relieved so much stacked anxiety. I blacked out of course because i ate 9 more pills. Mom called me ambulance but she was kinda used to it so not a big deal. I started to learn about research chemicals, damn i was obsessed. I started ordering every month. I felt like i found the best thing in my life. But it was always the same story. I tried a substance and i felt like it missed something. But i was sure if i try the next substance, it will be perfect. But it wasn't. This cycle was repeating again and again. I thought i finally found an escape, something that will make me forget about all my problems. But it made me forget about my family. About everything important in life. It kept my life making worse and worse.

One time i was high af on bromazolams with my best friend. We are men so we don't talk a lot about our problems. But i knew in that moment that he has not as big tolerance as me, and he will never remember what i will say to him. So i told him my plan. I told him i will take out a loan, as big as i can, buy all thing to my little brother and kill myself. He told me that if i look at his mom she looks always angry. Because when she was young, her little sister killed herself. And she is still sad today. And that no money can replace life. When i heard this i told myself I will never allow my brother to be sad because of this. I have to get my life together. I moved to new city, lived with my father. I started meditating, workout, reading books. But i couldn't stop the RCs. I kept relapsing. And then i got a girlfriend. Awesome girl who helped me to stop.

I am 2 years clean from meth, nearly year from all the drugs. She is anchor i needed. And the thing i told you, which i was looking for in all those RCs for so many years. God i don't know what is it, but i found it. I found it in boxing. I really can't name it so far but it is there. Maybe self esteem? I don't know. But i know you can do it too. Please don't give up it's worth a try. Love you guys.

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u/sniffinmynose — 1 day ago

5mapb first time dosage

Hi all! I’ve gotten ahold of some good quality 5mapb and am considering slicing up my Fourth of July party with it. I’m a 140lb male and I last did mdma April 27. Should I take 75mg? 100mg? More? Let me know. Also curious if mixing a small phenibut dose would help with the come up or just mute the effects too much to he worth it. Thank you!

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u/Cnidoo — 1 day ago

Holy fucking Cyclazadone

So i have been looking for a stimulant that wont pop for UA's and is like yayo, always loved me some Ritalin since ye olden days so searched for IPPH hella but couldn't find shit. No other analogues either.

Hesitated ordering Cyclazodone initially due to mixed reports claiming it's not very strong or potentially hepatotoxic etc. Decided fuck it i'll order a gram cause im tired of afinils and their lack of Drive / Push.

I just snorted 20mg of this stuff and on god the shit feels somewhere smack dab in between Methylphenidate and some GOOOD Fishscale.

Maybe my experience is a bit biased as i popped 500mg Soma earlier and im also on ~50mg Memantine (with high tolerance that is to M).

Anyone else get this affect ? The high is just so fucking clean. Like coke without as much sympathomimetic BS idk maybe i'm rambling at this point i feel this compound is underrated

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u/chemiculzzz — 2 days ago

Mebroqualone Report for Research purposes only

mebroqualone

It feels a little bit like DMT the way my body tingles and almost dissolves into the high. I can appreciate the taste but I often gag on it when taking a large toke. More than once I have ingested the substance and locked in on something, and in my peripheral I realize that I am not even sitting where I thought I was sitting. It’s psychoactive and trippy. I Favour the tinfoil but the bubble works just as well. I find that it rolls nicely without sticking on foil and that makes for a better smoke and taste. If you manage to burn it, it produces a distinct taste that is rather unpleasant. When I stand up to switch seats or move something I get this strong wobble in the legs basing from the knees almost like when an individual stands up too fast. Theres this swinging in my balance that reminds me of high dose dramamine, in the best way possible. The difference would be that it is a benzo-like intoxication rather than a head rush. appears to promote drooling and I feel the need to spit after taking a toke. It does not feel too unhealthy to smoke and it doesn’t require so much as where you are blowing your money quickly. It has a factor of compulsive redosing only because of the initial rush, which is like a strong alcohol intoxication similar to stronger substances such as Fentanyl when vaporized. In that regard it is worth mentioning that this substance may be beneficial for the withdrawal, tapering, or cravings from fentanyl and possibly other opioids. this is because of GABAergic relaxation and the ritual of using followed by a sedating potent rush. I imagine it would pair great with Suboxone or other medications of this nature. It leaves a numbing chemical like taste, not necessarily salty but prevalently a chemical of some sort. The smell is not very strong, similar to propane or maybe the aftermath of commercial cleaners for the household, but it can be noted that my sense of smell is initially impacted to where I cannot smell much of anything. When the rush passes it becomes a relaxing and euphoric substance for hours after similar to chamomile or valerian root but probably twice as strong. If you take GABAergic supplements or substances in combination like Valerian root it is noticable that it is extending and potentiating the substance. I procured this substance months prior, had a good experience with it, and sort of fiended the largest portion through vaporization. I will say that I did not get the temptation to immediately purchase more, even despite the almost anticlimactic ending of the last session. I have come back to it now in July and I last used this substance in January of this year. It is important to mention that I do not tend to use this substance without psychoactive substances in combination. these include Hydromorphone, at fairly low doses, Lisdexamfetamine, and more recently herbs and supplements such as chamomile tea and extract, as well as valerian root, which if I may mention just recently which works beautifully 1 year sober from benzos. When I began using valerian root for benzo withdrawal it had no effect in comparison and it bothered me greatly, but now it is a great combination. you can drink alcohol with Mebroqualone but I would advise a few beers at most otherwise you’ll be swaying on the toilet. This substance makes me want to do things like go out and just do whatever, go to the store just to restock groceries. I’m happy to answer any questions about this substance as I know that it does not have much of any information online pertaining to its effects or health concerns. For Qualuude like substances this is a great example of what the lemons in the wolf of wall street must of felt like once they kicked in and buddy could barely speak properly. It does not have the seizure potential like other Qualuude analogues, and if I may mention Ephinazone it also falls into the functional Quinazolines. not vapable and significantly weaker, but good for sleep and tripping out a little bit in this dizzy haze. Neither of these have been studied in any significant fashion so it is important to know these may be unsafe and have repercussions mentally and physically. To quote google AI “Quinazoline (C₈H₆N₂) is a bicyclic aromatic organic compound formed by fusing a benzene ring with a pyrimidine ring. It is highly valued as a chemical scaffold in pharmacology and medicinal chemistry for synthesizing antibiotics, anti-inflammatory drugs, and targeted cancer therapies” (https://en.wikipedia.org/wiki/GABAergic , https://pmc.ncbi.nlm.nih.gov/articles/PMC5491580/ , https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/gabaergic , https://pmc.ncbi.nlm.nih.gov/articles/PMC10388747/ , https://www.youtube.com/watch?v=61LEPVSDY-g , https://mhanational.org/resources/what-is-gaba/ ) I am a pharmacological researcher - tell me how I did on this post! I need it to be readable and informative!

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u/Cannibal_Pxnda — 2 days ago

50+mg of intravenous 4-HO-MET: a short trip report.

Before I quit IV use for what must have been about the ⁶⁶th time, I injected a dose that easily equalled and probably exceeded 50mg of 4-HO-MET. It was the most reckless thing I've ever done with a substance, and in a strange way it's part of why I finally got my life together.

The onset was near-instant and completely overwhelming. Within moments I couldn't see my own hands in front of my face. The visuals were so intense that I genuinely believed I'd gone blind and that this was permanent. Forget all you heard about the lack of existential dread and easy headspace boys and girls because this psychedelic kicked my ass relentlessly and these ranges she's ruthless on al axes of the DSM.

I tried to reach for my phone to call for help, but my coordination was gone. I tried to speak and couldn't form words. I was fully conscious and fully helpless at the same time.

There's a particular kind of humility that comes from lying there, unable to see, move, or speak, knowing you did this to yourself for no good reason. That experience stuck with me long after the effects wore off. It forced me to look honestly at where my use had taken me.

I never did anything like it again, and it marked the beginning of actually quitting IV usage.

The next report will be about my very last shot, +-70mg O-PCE. She's a BEAST.

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u/The_Snakey_Road — 2 days ago

Best RC Benzo to help with Opioid withdrawal

If anyone could help me out by sending me a message I’d be forever in your debt. No idea where to look or what to look for at the moment.

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u/Beginning_Anxious — 2 days ago

5-MAPB First Time Advice (also with 7-OH)

Hi, I've been taking 7OH for 2 years now, I take about 200-300mg throughout the day. My question is this, I recently got some 5-MAPB gummies from SoKo and I was wondering if it's okay to take even while being on the 7-OH. Like I want an experience like molly, but with the 7-OH just being in the background. It's not dangerous right ?

I was planning on taking it tonight even while being on the 7-OH because if i don't take the 7-OH I get withdrawals. I’m also 6’1 weigh about 160 pounds

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u/Snoo_43924 — 2 days ago

Which is most euphoric benzo for you guys? :) 🦋✨

This is what I tried:

- Rilmazolam

- Diazepam

- Bromazolam

- Pyrazolam

- Flubrotizolam

- Flubromazepam

- Norflurazepam

- Avizafone

- Bromonordiazepam

- Alpravalzafone

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u/mymymyoskw — 3 days ago

Evolution/Comparison of RC Dissociatives over the past decade

Hello my people, it's been quite a long time since I've actively participated in the RC community, almost 10 years, since RCsources was banned (RIP😞) and although I've dabbled with other substances over that time period, I'm pretty much clueless on what the dominant/most interesting/worthwhile dissos out right now are. Last RC dissos I ordered were 3-MEO-PCP, 3-HO-PCP (Possibly my favorite drug of all time), and DCK back in 2016/17. Was wondering what the current prevailing compounds are right now, mainly PCP analogues (or any other strange novel dissociatives), and how they stack up/compare to the old ones. Thanks!

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u/Confection_Secret — 2 days ago

Do you need weed with your benzos to make them stronger? 🍀

Because sometimes I take 15mg Alprazolam but the delusion ob sobriety is so strong, then I smoke some Weed and I‘m high af 😂

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u/mymymyoskw — 3 days ago

Cyclazodone Initial Experience & Review – Functional Stimulant / Adderall Replacement (30–50mg+ range)

Hey r/ResearchChemicals,

I’ve been using pressed Adderall for a while but got tired of the inconsistency. Some batches feel like cheap Euro speed with annoying side effects, others seem cut with meth and last forever. That unreliability is what pushed me to try Cyclazodone.

It was Father’s Day and the vendor had a 15% off sale, so I ordered. Shipping took 9 days even with express — not the end of the world but I was eager.

I researched doses beforehand. A lot of people start at 10mg, but with my amphetamine tolerance I decided 30-50mg would be more realistic. Started with 30mg as my test dose (no proper allergy test, just a tiny taste).

First Dose Experience (30mg):

Onset: Moderate cognitive euphoria — similar headspace to a good meth dose but much smoother and less intense.

Stimulation: Very functional. Excellent focus and motivation for work. No tweaking, no noticeable heart rate increase, and almost zero physical side effects.

Duration: Roughly 8 hours. I redosed 20mg at the end of the day for my second job and it boosted me right back up (even a bit stronger). That surprised me.

Note on redosing: I don’t really recommend it. Even if you’re tired, it’ll keep you up at night. It seems to accumulate easily — e.g., 10mg in the morning + 5mg later hits harder than 5mg on its own.

Multi-Day Use:

The next day I took 50mg after getting very little sleep. Surprisingly, I powered through the whole day with minimal fatigue despite the sleep deprivation. It’s very effective at masking tiredness without feeling “dirty.”

I ended up doing roughly three days on it with multiple 50mg doses before I finally got decent sleep. It wasn’t a wild recreational bender (I stayed functional and didn’t lose inhibitions), but I definitely overdid it.

Dose-response note: There’s a steep curve above 50mg. The jump from 50mg to 57mg felt more significant than 30mg to 50mg.

Overall Impressions:

Pros: Excellent functional stimulant. Smooth, productive, subtle enough that people around me couldn’t tell I was on anything. Good mood lift without being overly recreational. Much cleaner than pressed Adderall for daily/work use. Minimal vasoconstriction even after multiple days.

Cons: Sleep destruction is real — it builds up and makes it hard to wind down. Moderate mood drop / everything-feels-pointless when it wears off (but not the crushing anhedonia some stims cause).

Bottom line: For someone looking for a solid Adderall replacement as a functional stimulant, Cyclazodone is excellent in my experience. It’s not super recreational, but it provides clean stimulation and moderate euphoria at reasonable doses. Just respect the sleep issues and accumulation.

Has anyone else switched from street presses to Cyclazodone? How do your doses compare?

Will update if anything changes.

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u/Ryandubyah — 3 days ago

Can we get Netherlands sites to carry MGM/7oh?

It's made in Thailand for the most part and still legal there as far as I'm aware. I feel like we just need to route it a bit differently. Current manufacturers and suppliers need to be aware, let them know that this will be a huge money maker.

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u/SoggyGrayDuck — 3 days ago

3, 4MD PCP, O-PCE AND 2-FXiPR OR KETAMINE

For anyone with experience with all three of these chems, would you think it’d be a good time taking a smaller dose of OPCE, then 3 4MD PCP and maybe 3 MEO PCE and addd 2fxipr and/or ketamine during the experience. Or save the OPCE and vape what’s left of it before or after the 2fxipr ?

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u/CauliflowerStock8801 — 2 days ago

[Discussion / Info Gathering] 4-MPO (4-Methylphenidate oxadiazole derivative)

Hey guys,

With the recent bans, a new compound has been popping up on some of the shadier vendor sites over the last week: 4-MPO. We’ve seen one or two very brief reports, but we are essentially flying blind, and people are gonna start buying this out of desperation.

Chemically, this is basically a phenidate derivative where the ester group has been replaced by a 1,2,4-oxadiazole ring (similar to what was done with 3-FPO), and a methyl group in the 4-position. The oxadiazole ring means it bypasses standard esterase breakdown, so it's structurally "armored". The half-life is likely longer, and stacking/redosing could easily lead to a massive overamp if we aren't careful.

So far, we literally only have ONE user report floating around in another thread. The guy stated:

"My order arrived yesterday, and I was really surprised. It works very well, and the smell is very pleasant. Just be careful not to redose too much, although I hardly had any comedown; I slept well. It's a very powdery white and even smells nice. The best thing I've tried since the ban."

This is frankly a bit concerning regarding the "pleasant smell" (leftover solvents/impurities from these rushed labs?), and we still have zero info on his ROA or dosage.

If anyone has received their batch and researched it, please drop your data below so we can establish a baseline for harm reduction. We need real info, not just vendor marketing.

Please try to include:

Dosage (and did you use a scale?):

ROA (Oral, IN, etc.):

Duration (Onset, Peak, Comedown):

Effects (Euphoria? Functional? Serotonergic warmth vs Dopaminergic push?):

Side effects (Heart rate, anxiety, ability to sleep):

Physical traits (Color, texture, smell, burn if snorted?):

Let's do some proper street science and keep each other safe. Don't be the guinea pig that takes 50mg of an unknown oxadiazole without writing it down!

Also, a quick question: is anyone planning to send a sample of this to a lab for full GC/MS testing (Energy Control, DrugsData, etc.) ?

If nobody has it planned, I will order a small sample and forward it to my contacts at a government-funded harm reduction lab. I have free access to state-of-the-art analytical equipment, so we can get a definitive, official profile on what's actually in this "pleasant smelling" powder.

We need real chemistry, not vendor marketing.

Stay safe! ✌️

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u/Smooth_Earth_2948 — 3 days ago

The original amphetamine 'gold rush' of the 1930s/40s

A few excerpts from the paper:

>The original amphetamine epidemic was generated by the pharmaceutical industry and medical profession as a byproduct of routine commercial drug development and competition.

>... Fueled by advertising and marketing urging doctors to prescribe the drug for depression...annual sales of Benzedrine tablets grew steadily to about $500000 in 1941. ...by 1962, US production reached an estimated 80,000kg of amphetamine salts. ...amphetamines became 1st-line treatments for emotional distress and psychosomatic complaints in the 1950s.

From the paper titled "Amphetamines: a current epidemic": >There is currently a high volume of regular amphetamine usage within the United States adult population.

>Due to the risk of misdiagnosis and the limited amount of medical research into amphetamine addiction and long-term efficacy, practitioners should consider seeking additional educational resources before diagnosing patients with ADHD and prescribing daily, long-term use of amphetamines.

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u/Kalki_X — 3 days ago

Anyone have good experiences with 2-cmc?

My plug is out of 2mmc and offered 2cmc instead

2mmc always made me crazy social, very very horny and I was able to enjoy any kind of activity and got a lot of backlogs done.

The 2mmc always came in purely white, big rocks that were hard to crush, the 2cmc is yellow in color and made of a large amount of small crystals (tho the plug might have crushed it for transport). Crushed to powder it turns yellow. has a very light "moist" touch to it

also the plug gave me a simple of nep and 4mmc which both are crystal clear white

what are it's effects like? I only do nasal as oral gives me stomach issues but I'm prone to binging and redosing due to lifelong issues with anhedonia (speed makes me sleepy lol)

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u/Katzerinya — 3 days ago

Lsd/5-mapb candy flip. Asking for dosage/guidance/experiences

I have almost 4 years experience with lsd between heroic and lower dosages and recently have came into touch with 5-mapb. It’s a lovely chemical as is and would be interested in harm reduction taking both it and lsd together!

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u/Living-Emu-1798 — 2 days ago