Push-and-refill mechanism of CSF hydrodynamics: seeking feedback and MRI verification collaborators
The classical bulk-flow model of CSF — continuous secretion by choroid plexus, flow through ventricles, absorption via arachnoid granulations — has faced mounting challenges over the past two decades (Orešković & Klarica 2010, 2011; Greitz 2004). Yet an alternative coherent framework for ventricular CSF dynamics within the cardiac cycle has not been fully articulated.
I am an independent researcher (physician, Slovenia) with a long-standing interest in intracraniovertebral volume homeostasis. My preprint proposes a push-and-refill mechanism: freshly actively formed (FAF) CSF is released passively into the cerebral ventricles during diastole: https://doi.org/10.5281/zenodo.18783880.
This model predicts a specific, testable signature: ventricular volume should increase during diastole, coinciding with net aqueductal flow directed caudally. To my knowledge, no published study has combined simultaneous cine-volumetric ventricular MRI with directional PC-MRI at the aqueduct of Sylvius within a single cardiac cycle protocol — which represents the critical verification gap.
I am looking for:
- Critical engagement with the volumetric/flow logic
- Awareness of any existing datasets that might bear on this (cine MRI + aqueductal PC-MRI in the same subjects)
- Potential collaborators with access to cardiac-gated 4D flow or PC-MRI protocols
Preprint: https://doi.org/10.5281/zenodo.18783880