u/Apprehensive_Zone400

Stage 4 NSCLC, PD-L1 <1%, no targetable mutations, heart condition. looking for hopeful stories

Hi everyone,

My father (69) has recently been diagnosed with stage 4 non-small cell lung cancer.

He has both adenocarcinoma and squamous features, PD-L1 is below 1%, and molecular testing did not find any targetable mutations.

Bones Mets (C7, T1 - T3), unable to move. Oxygen therapy 24/7.

What makes things more complicated is that he also has significant heart disease, with an ejection fraction of around 35%, so his doctors are trying to choose a treatment that will not put too much stress on his heart.

I know every case is different and I'm not looking for medical advice or miracle treatments. Right now, I would really appreciate hearing from people who have been in a similar situation, either patients themselves or family members.

Has anyone here had stage 4 NSCLC with low/negative PD-L1 and no actionable mutations, especially with other serious health problems that limited treatment options? How did things go? Did you or your loved one respond well to a gentler treatment plan? Were there periods of stability or good quality of life that you didn't expect at the beginning?

At the moment everything feels very scary, and I think hearing some real stories of people who managed to have meaningful time, stability, or even unexpectedly good responses would help us a lot.

Thank you to anyone willing to share their experience.

Gio

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u/Apprehensive_Zone400 — 7 days ago