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What if, instead of this iconic line, Wanda says "No. More mutants." in Secret Wars?
Obviously, the MCU's started introducing mutants, so they're already here, but judging by the current state of the MCU, they are few and far between. With that in mind, Wanda (or a variant of hers, since our Wanda's assumed to be dead) might modify her original statement from the House of M storyline, which would then give us an in-universe explanation for why we're only now getting the X-Men and other mutant characters...
u/Bernd_das_Brot_69 — 17 hours ago