u/Both-Following-8169

I am closing in on 2 months of Tirzepatide. I did 2.5mg for four weeks, and now I am almost done with my month of 5mg. Total weight loss: 4 pounds. My appetite is a bit lower but the food noise is still very loud. My friend started at the same time and has already lost almost 30 pounds.

My doctor says I am just a slow responder and wants me to move up to 7.5mg next. But I know some people just do not react to this medication at all. At what point do you just accept that you might be one of those people and stop paying for it?

So I've been following the CagriSema news for a while because I was really hoping it would be the next big thing, and I know a lot of other people in this sub have been curious about it too. The full results from the REDEFINE 4 trial just came out, and the situation is actually more interesting than the headlines make it sound. And just for the record, I am not affiliated with anything, just someone who read a bit of the paper after it got linked by a friend I met on the discord server (TY villo!) and also wanted to get some input on the topic.

For those who missed the news, Novo Nordisk announced back in February that their combo drug CagriSema failed to meet the primary endpoint of noninferiority compared to tirzepatide 15mg. The open-label phase 3 trial included 809 participants with a mean baseline weight of about 252 pounds, and tirzepatide led to a slightly higher weight loss of 25.5% compared to CagriSema's 23%. But the thing is the patients on CagriSema still lost an average of 23% of their body weight over 84 weeks. That's not failure. That's actually pretty incredible weight loss for any medication. It's just that tirzepatide was even more effective. The company is moving forward with a higher-dose trial planned for the second half of 2026, and an FDA decision is anticipated by late 2026.

Edit: I still think cagrisema is something to really look forward to but I guess it’ll be different for others

Edit Edit: Discord server mentioned is a public, community one, here’s the link if y’all want to join in too https://discord.gg/3BBGejHjqp

hey everyone, 24M, 5'8 and 210 lbs here and pretty new to all of this. been looking into weight loss options for a while and kept coming across reta so i figured i'd actually look into it properly

my main question is just where do i start. like what's the actual process before jumping in. do i need to get any bloodwork done beforehand or get tested for anything to make sure i'm not going to have a bad reaction to it

genuinely have no idea what the checklist looks like before starting and don't want to just go in blind. any help from people who've been through this would be really appreciated

I had fucking massive success with tirzepatide, lost weight and felt great with zero side effects. But my 22 year old son is a total tank and both times he tried a GLP-1 he got hit with pancreatitis. Now his doctors say he is banned from them forever and it is so fucking annoying because he has been a fat mess for years and needs real help. He refuses to do surgery and I am watching him rot with zero options. Is it a literal death sentence if I just buy him GLP-1s from the grey market and run them anyway? He has a hundred pounds to lose and is getting completely fucked.

I used compounded tirzepatide (from a 503a pharmacy) for 4 months, then switched to brand Zepbound (with coupon) for 7 months. I tracked every dollar.

Compounded tirzepatide (7.5mg):

Monthly cost: $325

Labs required: $0 (insurance covered)

Telehealth visit: $75 every 3 months

Annual total: $4,200

Brand Zepbound (10mg) with coupon:

Monthly cost after coupon: $350 (had to reapply every month)

Insurance covered? No (denied)

Doctor visits: $150 copay every 3 months

Annual total: $4,800

The gap was smaller than I expected ($600/year). But the compounded version required more hassle (reconstitution, syringes, questionable sterility). The brand version was more convenient but required coupon renewals and pharmacy runs. For now, I'm back on compounded because my coupon ran out and the cash price is just too high. But I miss the convenience.

I'm a 34F, started at 292lbs and I'm currently stuck at 262lbs after seven months on Mounjaro. I'm on 12.5mg right now. I lost about 30lbs at first, but it feels like a losing battle compared to everyone else on here who claims they just forget to eat. My appetite suppression completely disappears by the weekend. I spend Friday through Sunday just fighting off the food noise and it is absolute hell. It's genuinely terrifying to feel like you are failing on the one drug that is supposed to be foolproof. Am I just a complete non-responder who needs more discipline, or is my food addiction actually stronger than the medication at this point?

I have no idea why guys on a clinic protocol completely lie about how much the stuff actually builds muscle and burns fat. You see these dudes who never touched a weight before, they get a script, pack on twenty pounds of lean mass in a year, and then try to preach about hard work and motivation. They act like injecting twice a week to sit at a permanent 900 total testosterone is exactly the same as a natural guy who hits that number for five minutes in the morning. It is a massive chemical advantage and they refuse to admit it because they want everyone to think their results are just from grinding.

I trained natural for ten years before moving to TRT and then actual gear, so I know exactly how different the reality is. This whole trend of calling it "natural plus" is ruining the expectations for younger guys who are actually putting the work in. When a guy on a permanent exogenous supply claims his body is just the result of a good routine, he is basically telling natural lifters that they are just lazy. It is incredibly slimy behavior to completely transform your physique with hormones and then act offended when people point out that the compounds are doing the work.

I saw a supplier today that has ten milligram vials listed for less than fifty bucks. I am obviously not going to name drop the site or post a link so I do not break the rules here, but that price feels incredibly fake to me. Is there any chance a vendor can actually sell it that cheap and still have it be real? What is the standard average price you guys are dropping on your orders right now? Just trying to figure out if I need to completely avoid this site.

Novo Nordisk's CagriSema (semaglutide + cagrilintide fixed-dose combo) posted 22.7% weight loss in the REDEFINE 1 trial in adults without diabetes . That's means it’s approaching bariatric surgery territory. Which is awesome for people who just can’t live with surgery or fathom the thought of getting it.

The full Phase 3 cardiovascular outcomes data from REDEFINE 3 is expected Q4 2026. If the safety profile holds, this could become the new standard for people who need maximum weight loss. If there is anyone here that was on the trials I wanna know how it was and how the side effects compared to straight semaglutide?