r/GLP1ResearchTalk

I was on sema for 7 weeks. (Weg) to be exact. I was on the .25mg dose for 5 and .5mg for 2. I started feeling really anxious around the 4th week. And everything just went downhill from there. I assumed my body was just needing to get use to it but i was wrong. When I moved up a dose things got progressively worse. I was in the ER. I was at the cardiologist and had a heart monitor on. Got abdominal ultrasounds. I couldn’t eat the first couple weeks post shot (im about to hit the month mark). I felt extremely anxious, wishing i was d#ad, any bite of food would make me gag. Even just drinking water made me sick. Never in my life had my anxiety been so bad that i needed anxiety medication. And now i am on some. Slowly im able to eat a bit more but i still struggle a lot with morning anxiety. My stomach feels tight and uncomfortable. With a stinging feeling almost in my chest. Just feeling of fear. I hope i can get back to me soon because this is awful. And i know i am not the only one dealing with this. If youre on here looking for answers hoping it gets better it will🥺 Slowly but surely. Sending hugs to all affected by these drugs🫂

You guys, I am SO mad at myself. I ordered a refill of my wegovy on 7/1, and I wasn’t expecting it to arrive until tomorrow because of the holiday. I stupidly didn’t check my email at all and my package was delivered on 7/2, which was 3 days ago!!!! The liquid in the pens still appears clear with no particles or anything. They also don’t feel warm they feel room temp. The package wasn’t outside it was in the entryway of my apt building. I’m most likely going to still use it because it’s clear and I paid for it 😂 but is this ok?? 😂😭 Google basically told me it’s ok at room temp for 28 days and if the liquid is clear to not worry

Hi how much BAC water should be added to a 60 mg bottle of tirzepatide?

So no one outside of my immediate family knows I’m taking GLP-1, I’m not ashamed of it, but it’s still sort of a taboo where I come from.

I was talking to someone the other day about it and they said “Yeah look at XYZ, they’ve got the ozempic face” so I asked them what it meant and they said it’s the face people get when they lose weight using ozempic.

I tried to counter it, saying it’s natural and pretty normal for people’s facial structure to change after they loose a bunch of weight and the person said “no, you can tell when someone has lost weight with ozempic”

So my question is, is ozempic face a thing? And am I going to end up with an ozempic face? And if yes, how do i avoid it?

I have never in my life been this bad when it comes to mental health, and I truly believe it's because of the GLP-1 (Ozempic) I've been taking. Some peers of mine and I have been on it for about 4 months and it's caused SEVERE depression, SI, and anhedonia in some of us, and anxiety reduction in others. I'm wondering if anybody else has had mental health side effects from Ozempic? I took my last shot two weeks ago and it's been absolute hell. I think there is an extreme amount in my system since people metabolize the drug differently and the effects are nearly unbearable. Different perspectives would be appreciated. I have honestly never felt this bad in my life out of no where. There is definitely something messing with neurotransmitters created in the gut.

What going on? I have 10 kilos max to lose and want to go slow and steady on daily Saxenda jabs. Also reduce severe side effects so I’m currently on 1mg daily after 3 weeks.

I’ve been strength training for 1 year prior to this. In only a few days my skin has lost electricity and I’ve been eating 3 meals a day and high protein so haven’t dropped calories drastically.

Reddit: Let's bombard her with endless expensive compound pharmacy ads. Me carefully tiptoeing in: Oh hi, maybe I we/can share knowledge. Reddit: 🚨🚔❌🚫🚔🚨

A lot of GLP-1 discussion is focused on the obvious stuff: appetite suppression, weight loss, food noise going quiet, and before/after results.

But I’m more interested in the parts people don’t always mention.

For example, some people say GLP-1s changed their whole relationship with food. Not just eating less, but not caring about food the same way anymore. For some, that sounds freeing. For others, it seems weirdly flat, like they lost a source of comfort or reward they didn’t realize they depended on.

There’s also the gym side. If appetite drops too much, getting enough protein and calories can become harder, and training can feel different. Some people seem to lose weight quickly but then struggle with energy, strength, or recovery if they’re not careful.

Then there’s the mental side: mood, motivation, alcohol cravings, impulse control, sleep, and even just how people structure their day when food is no longer the main thing they think about.

I’m not posting this as medical advice or to hype anything. I’m just curious about the less obvious parts.

For people who have researched or used GLP-1 programs, what surprised you the most that nobody really warned you about?

I saw an industry projection saying tirzepatide could become the highest-selling drug in the world in 2026, with estimated revenue around $45 billion.

That’s wild when you think about how many people still can’t access it because their insurance plan excludes weight-loss medications.

At this point, it’s clearly not some experimental niche product with uncertain demand. The demand is obvious, the revenue is enormous, and the clinical interest is everywhere. Yet for obesity treatment, coverage is still inconsistent or completely unavailable for a lot of patients.

That makes the access issue feel less like a medical question and more like a pricing, insurance, and policy problem.

How do people think this changes over the next few years — do insurers eventually start covering obesity medications more broadly, or does this stay mostly pay-out-of-pocket for anyone without the “right” diagnosis?

Been seeing eloralintide / LY3841136 pop up more lately and I’m wondering if people actually think it’s something to keep an eye on or if it’s just early hype.

I know it’s not a GLP-1 and is more on the amylin side, kind of in that cagri/CagriSema lane, but some people seem to be comparing the attention around it to early reta.

For anyone who follows this stuff, do you think eloralintide could end up being one of the next bigger compounds people talk about, or is it still way too early until more data comes out?

I was also invited into a group order for this and was wondering how safe that even is? also curious if people think it’s actually worth watching.

Hi all I have been on 15mg of Trizepitide per mL for about 3 weeks now. I’m on 6mg and I have seen no improvement. Next week my doc wants me to up to 9mg. Is this normal? For reference I am 33, 180lbs. 5ft 4, female.

So I ordered a 10ML lipo c..I read that im suppose to take 1ml weekly...simple enough....well..I got it in and its a 3ml vial and need to be reconstituted...so do I just divide the 3ml by 10 and now that's my weekly dose?

https://www.reddit.com/r/GLP1ResearchTalk/s/fQnvZAYbCp

Do you guys know those posts, where the OP comes back with an update about how they never expected the post to get so much attention? Well this is another one of those updates.

I posted our story in several different subreddits earlier this week. My goal was to get this information out there in the hopes that it stopped someone else from making the same mistakes we did. I have been reading comments, answering questions, and responding to DMs ever since. I Just wanted to say thank you to everyone who has shown support for my wife and I. It has really meant a lot in our darkest hour. The internet can truly surprise you once in a while.

So on to the update. My wife finally got to come home yesterday. After a full week in recovery, she was finally strong enough to return home. It was one of the happiest moments of my life, but also one of the most sobering moments as well. We have spent the last 24 hours taking stock of our new life. They took a lot more than just a piece of her colon in that surgery. They took our sense of safety, our care free attitude, and left us trying to navigate the complications of colostomy and oncology. That is weighing very heavily on her right now. I do the best I can to lift her spirits, but I'd be lying if I said she isn't struggling.

One the brighter side, the pathology report came back yesterday as well, and it was better than we expected. No cancer was detected in the lymph nodes, appendix, small intestine, or abdominal fluid. THIS WAS GREAT NEWS!!! There is one lesion left in the liver, but it's small, very treatable, and we already knew that was there. So we're lucky that cancer wasn't detected anywhere unexpected.

We are gearing up for the biggest fight of our lives. We are 100% determined to beat this together. WE ARE ABOUT TO KICK CANCERS ASS!!! It doesn't stand a chance.

So we have started to plan our victory party. At some point in the near future she will be diagnosed NED, and we will be throwing the biggest celebration at a resort bar in Tahiti. You are all invited to join us. We can all raise a glass to the death of cancer!!!

Once again, from both my wife and I, thank you all for your support. I can't tell you how much it has meant.

Has anyone had experience on Mounjaro / wegovy with starting bmi of 23-25?

Not sure what to expect

I know from reading various posts and studies online that there's approx 9-15% of people are supposedly non-responders to GLP1 antagonists like Semaglutide and Tirzepatide. But, does anyone know if there is a definitive test people can take to confirm this diagnosis yet or not?

For added context, I was previously on 15mg Mounjaro after titrating up which took just over a year ish because I had excruciating side effects every time I stepped up (including 3am calls with on-call doctors and hospital visits because of the pain).

I stopped taking Mounjaro when the prices spiked up September 2025. I couldn't afford it and at the time my weight loss had plateaued despite tightly controlling my calorie intake and doing heavy 3hr gym sessions 3 days a week (full body workouts + Cardio + Swimming).

I started at just over 200kg in Dec 2023 and started dieting and working out then.

I started taking Mounjaro at 187.6kg towards the end of July 2024.

August 2025 - Sept 2025 (when i stopped the jabs) I was fluctuating weekly around 165kg with my lowest weigh-in being 163.8kg

From Sept 2025 - Jan 2026 I continued to float around the 165kg mark.

Feb 2026 there was a fire that shut my gym down for a couple months and I fell off the wagon, stopped tracking food, stopped gymming, started playing world of warcraft again because of the nostalgia and fomo from a new expac and I'm now back up to 180Kg and sick of my own weaknesses.

SO, I started taking WeGovy 11 weeks ago, currently on the 1mg dosage and I've not lost any weight at all in this time, over the 11 weeks I’ve stayed exactly at 180.0kg. I've not been feeling any of the usual effects from the drug at all, no reduction in appetite, obviously no weight loss, nothing..

I'm supposed to titrate up again to the next dose of wegovy but I'm starting to lose hope again and questioning whether there's any actual fucking point to doing this and spending all this money if im not reacting to it at all.

So yeah,

TLDR: knowing for definite if I’m a non-responder or not would be great. so, anybody heard anything about testing being available and accurate?