r/GLP1ResearchTalk

I’ve been in tirz for 3 months now I am with brello and they started me off at 2.2mg then 4.4 then 6.6. I haven’t lost ANYTNING! So I skipped 6.6 and started taking 8.8 after 4.4. So I’m on my 3rd shot of 8.8 and still nothing. Food noise is horrible, I’m still hungry and it’s hard to stay within a deficit. Starting weight 330. Current weight is 332… not sure what I’m doing wrong. I don’t want to renew with brello as now I’m thinking something is wrong with the meds they’ve been giving to me. I’m considering Reta & going back to semaglutide. I took Sema from amble last year and was losing weight my very first month and the starter does for that was .25 and I lost 50lbs in 3 months. Yes I was sick as a dog and had horrible nausea and diarrhea but the weight was dropping so fast and I did feel good mentally, zero food noise!! I’m considering just going back to sema.. any advice?

My question is how does Tirzepatide from the gray market compare to compounding tirz? How much weight have people lost off the gray market tirz?

53 F, 5'7". SW 175 lbs CW 123 lbs.

I was losing weight slowly over the course of a year when I accidentally took a triple dose of tirz (wrong units on syringe). I had no idea that I had taken too much, but I had no appetite whatsoever and quickly reached my TW of 130. However the excitement of that was overshadowed by the amazing fact that I had lost all interest in drinking alcohol. For years I was a nearly daily drinker and often heavy. I felt like I had almost no control over whether I drank or not. Suddenly, I had no desire to drink. Started waking up feeling like an actual human who can actually be productive. This is so much more of a major life change than the weight loss, I cannot begin to tell you.

But, now that I am in maintenance mode and taking lower doses of tirz to stop losing more weight (I'm now almost underweight), I am noticing the urge to drink coming back. I'm trying to find the perfect dose that allows me to be able to eat without wanting to drink but it's difficult. Despite lowering my dose to 7.5 mg the last time, I cannot eat. At all. Can barely choke down smoothies and shakes. This morning I went to play pickleball as usual and despite having drank a 25 mg protein shake, I was too weak and out of breath to play at all.

So I'm between a rock and a hard place now. Does anyone have tips for me. Thank you.

EDIT: I should have mentioned that I was seeing a psychiatrist for many years who tried to treat my ADHD and drinking with various therapies and medications, including naltrexone. Nothing worked. For my own personal reasons, AA is not an option for me. Tirz has given me the ability to not drink unless I decide to (celebrating with friends, etc.) and when I do, it's not much. This is the life I've been working towards for so many years and tirz can give it to me, if only I can find the right dose, and keep affording it out of pocket.

My research subject is 41F SW80kg CW66kg
5ft9.5
She has started lifting weights and wants to gain more muscle for the slim fit look (she’s looking kinda skinny). She is currently on 5mg Tirz. Wondering if my rs should switch to Reta at a low dose maybe 2mg so she has a reasonable amount food noise whilst still burning fat, maintaining and gaining muscle.
Anyone done this switch for this reason?

I’ve been on Rybelsus for about a year now and would really appreciate advice from people who have been in a similar situation.

I started at around 63–64 kg and gradually moved from 3 mg → 7 mg → 14 mg, which I’m currently taking consistently. I did have periods of inconsistent use because of travel/events, but overall my weight progression was roughly:

63–64 kg → 61 → 60 → 59 → 58 kg

So I’ve lost around 6 kg, but I've now been stuck around 57.9–58 kg for several months. I'm 5'3" and I know I'm currently at a healthy BMI, but my personal goal was around 55 kg.

More importantly, over the last few weeks I've noticed my food noise and appetite returning.

I'm still nowhere near my pre-Rybelsus appetite - I recently couldn't finish the last slice of an 8-inch pizza - and my weight isn't increasing, so I assume it's still doing something. But the difference in appetite and satiety is becoming increasingly noticeable.

At this point, I'm wondering what my next step should be. Do I stay on 14 mg because it's clearly helping me maintain the weight loss? Accept that I've probably reached my plateau? Discuss switching treatments with my doctor? Or is there something else worth considering after a year on Rybelsus?

Would really appreciate advice/experiences from long-term Rybelsus or semaglutide users who reached this stage.

One clarification: I know the obvious suggestion is to switch to an injectable like Ozempic/Wegovy, but for personal reasons injectable medication is not an option for me, so I'm specifically looking for advice about what I can realistically do while staying with an oral medication/Rybelsus or any other option.

I just want to understand what my realistic options are after a year on 14 mg and whether people have successfully continued losing after a plateau like this.

I wounder why this is not getting enough attention.

Phase 2b data with semaglutide + 3 mg enobosarm (ostarine) showed ~99% relative preservation of lean mass vs semaglutide alone.

That might be the biggest breakthrough in weight loss, imagine losing only fat and keeping muscle without much effort.

I already ordered it online, might give it a try. Trial results look great, no major adverse effects.

Anyone here taking it, considering adding it, or avoiding SARMs entirely?

My daughter pinned her first dose of sema Saturday night about 6pm. She did the lowest dose and she was SICK - it was bad and I almost took her to the ER. She had constant nausea and constant vomiting from 8pm Saturday until Sunday at 5pm where she could finally hold down some electrolytes. She couldn't go to school or work.

She still wants to try with either tirz or reta. Which is recommended to someone who had such severe vomiting on semaglutide?

Hi all. I will likely be starting mounjaro in September. And I was hoping to hear some people’s experience in using mounjaro specifically! Thank you

Looking at placing an order, have been previously scammed by a different supplier so just wanting to double check.

Thank you

Hi, I have been on Reta for 8 months now. It was fantastic for awhile but now my food noise is out of control and it is not working the way it used to. It seems I have almost built a tolerance. I’ve been at the same weight for MONTHS and have made all other adjustments from lifestyle to upping my dosage but the food noise is so loud and I never experienced that with Reta before. I am considering switching to a different GLP but I haven’t tried any others before. Has anyone experienced this and what GLP would be the best conversion. I’d like something strong.

For ppl actually taking it, or who have switched from tirz. I'm switching from semaglutide to tirz, its more expensive but i haven't seen results from sema. is it the same for ppl swithcing to trying reta?

Someone recommended I try Biohacklab. Anyone else have experience with them or success stories. I want to make sure I actually get what I pay for

Has anyone ever took a glp while doing keto? I started a glp along with keto and I lost around 3.5lbs this week but not sure which is working since I started them at the same time. I’m wondering if I should stop the glp so I could see if I still lose with keto. I would prefer to not take any drugs and also not lose rapidly.

Please help! Im recovering from binge eating disorder and Ive been on reta for 6 weeks. 1.5mg for 5 weeks and now at 2mg.

Im only 148cm and I stopped binging for the first few weeks, but when I titrated up to 2mg last week my hunger skyrocketed and the binge urges are back.

I workout everyday and my average steps is 20k, Ive also been eating properly and hitting my intake but despite all this I binged 3x last week and binged right after I pinned today.

I heard tirz does a better job at quieting the food noise?

I sent a request for a doctors evaluation on July 7 and was asked for which prescription I was requesting. I was suggested and selected tirzepatide which was $149/month. I was charged this amount. I didn’t receive any confirmation email but called their number and confirmed I paid for tirzepatide and was told they were having issues with their server and should receive an email shortly. I was shipped an injection and double checked my account before taking it and my account stated I was on the tirzeptide plan.

Aug 3 I called and spoke with a representative that confirmed system issues and said I would be getting emails starting that day. They also told me that I paid for tirzepatide, and was signed up for tirzepatide but I was sent semaglutide. I was told a supervisor would call me back. I called 2 days later where a 3rd person confirmed system issues and that I should get emails now, as I still wasn’t receiving them. They also confirmed I paid for tirzepatide, said I was charged $89, the correct amount for semaglutide, for my 2nd charge and that it was on its way. I put in another request for a supervisor. I tried to screenshot my account and while my screen still said I was on the tirzepatide plan the prescription had been changed to reflect what they had actually shipped - semaglutide.

I spoke with the supervisor, Kaylie, on August 7th who also confirmed that I was charged for tirzepatide in July but was shipped Semaglutide instead. She told me that I would be refunded that $149 because I was given the wrong order, told that I should throw out the semaglutide order that was already shipped, and that my next order would be free of charge. Instead I was charged an additional $149 and there was no effort to refund the original order made in July. I reached out today and the customer service agent said there was no record of my account, and in text they told me they meant I would be refunded $89.

Even without the refunds and free shipment Kaylie promised, the charges they show on my account do not align with what I was actually charged. Based on their records I should have been charged $238 in total but $298 was taken from my account.

Been on reta for the last year and sort of stalled. Was thinking of switching to Tirz as I have never used it before thinking my body will respond how I first did with Reta.

Any thoughts or experiences with tirz vs reta?

GLP1 Forum is NOT A SOURCE. Please do not remove.

This site is a scam. I tried to post in the appropriate forum that a premier sold me fake HGH and attached the COA. The post was never approved. Yes, I followed the rules exactly. I noticed that someone posted that they had seen my TG group post about this (because white cap H36 from the reseller was all fake, and many people had received it and people were talking about it en masse on TG) and asked about my TG post, to which the admin responded, "That's bullshit, lies, never happens," yada yada. I responded to it, saying that was me; I have a COA, but the premier vendor made me whole, which, of course, I was permabanned. I posted on the resellers TG which of course was automatically removed within minutes.

Yeah, yeah, a reseller starting with a J was called out for endotoxins earlier this year, but after that, you cannot report fake or bad COAs. The reseller that sold me fake HGH does not start with a J.

In a way, the admin is an accessory to felony wire fraud because he profits from any vendor listed on this site and is blocking warning buyers about fake products. No, I will not name the vendor. Don't bother DM me.

These premier vendors constantly sell fake Tirz and Reta; it's all over independent TG groups.

This is just a warning that GLP1 is a pay-for-play scam site. And on TG groups, the number of fake and bad COAs is alarming. This is why you should always send a vial from your batch kits off for testing.

Edit: The admin is covering up, thereby allowing fraudulent transactions. He is either committing felony wire fraud or is an accessory to it.

Edit2: please do give the mods a reason to remove this post by mentioning sources!

Edit3: The admin is a Nazi. Look at his profile pic. Prove me wrong.