Jackbox Party Pack 6's Push The Button is a great example of a game creating isolation and loneliness within players. Or at least it is for me, because all my friends say I'm a lying, manipulating, scumbag and none of them want to hang out with me anymore after playing this game.
In Half-Life (1998), the G-Man's full name is Government Man. Which begs the question on what kind of parent names their kid Government. That's a dumb ass name.