For almost a year I was dealing with symptoms that nobody could explain.

My main symptoms were:

• Fatigue
• Brain fog
• Difficulty concentrating
• Memory problems
• Numbness and tingling in my hands

Routine blood tests were essentially normal, so no one suspected homocysteine.

Eventually, my doctor ordered a homocysteine test, and that's when everything started to make sense.

February 2026 (before treatment)

My initial blood tests showed:

• Homocysteine: 25.7 µmol/L
• Folate: 6.69 ng/mL
• Vitamin B12: 401 pg/mL

My doctor suspected that low folate was the main cause of the elevated homocysteine.

On February I started taking:

• Methylcobalamin (Vitamin B12) – 1000 mcg/day
• Methylfolate – 1000 mcg/day
• Vitamin B6 (P5P) – 50 mg/day

April 2026

After about seven weeks, my results had improved:

• Homocysteine: 19.2 µmol/L
• Folate: 17.40 ng/mL
• Vitamin B12: 497 pg/mL

So the supplements were clearly working, but my homocysteine was still well above the optimal range.

My doctor decided to investigate further and ordered additional vitamin testing.

That's when we found something unexpected:

Vitamin B2 (Riboflavin): <2 µg/L (deficient).

Since riboflavin is an essential cofactor for the MTHFR enzyme, I started taking 100 mg/day in mid-April.

June 2026

About two months later, my blood work showed:

• Homocysteine: 13.8 µmol/L
• Folate: >24.0 ng/mL
• Vitamin B12: 533 pg/mL
• Vitamin B2 (Riboflavin): 5 µg/L (back within the normal range)

How I feel today

The improvement has been remarkable.

• My fatigue has almost disappeared.
• The brain fog is gone.
• I can concentrate properly again.
• My memory is much better.
• The numbness and tingling in my hands has completely disappeared.

Overall, I finally feel like myself again.

What I learned

This is only my personal experience, but I found something interesting.

Correcting folate, B12 and B6 reduced my homocysteine from 25.7 to 19.2 µmol/L, but it remained elevated.

The turning point was discovering that I was deficient in vitamin B2. After adding riboflavin, my homocysteine dropped further to 13.8 µmol/L, while my symptoms gradually resolved.

I'm not claiming that vitamin B2 alone was responsible—this was likely the result of correcting multiple deficiencies—but riboflavin appeared to be the missing piece that allowed my homocysteine to return to the normal range.

I wanted to share my experience because I rarely see vitamin B2 discussed when people talk about elevated homocysteine, despite its role in one-carbon metabolism.

Has anyone else here found that riboflavin was the missing piece for lowering their homocysteine?