r/MTHFR

The issue I'm facing is that I have awful reactions to B vitamins. The best description for when I take them is I feel like my body is full of toxins and my blood is full of poison. It's a systemic feeling. I get headaches, nausea, but it does not feel gut related - I get zero digestive symptoms. It's this full body type sickness.

I'm absolutely great day 1, day 2, usually around day 4 I get sick. But the first few days I feel great - it helps my energy, mood, dysautonomia symptoms. I genuinely think I would benefit a lot from them. But then the sickness comes. I've tried pushing through but the longer I stay on them the worse it gets. It's like its worse the more I have in my system. Doesn't matter how little I take (took crumbs before) it always catches up to me.

I just found a folate deficiency so I genuinely do need it. Started 1.25 mg folic acid (prescribed 5mg.) Made it to day 4 then had to bail. Takes a few days to a week-ish for symptoms to pass, as though my body is processing something out.

Last year I tried a bunch of different ones. I'm okay on B2, bad on B1, B9 and B12. I'm pretty sure I've tried methylated and non-methylated versions of at least b12, maybe B9. But this current run is definitely folic acid as it's doctor prescription.

I've tried MCAS treatment with no benefit too.

I also have a bunch of chronic health issues - ME/CFS, Dysautonomia and chronic migraine. But none of these symptoms/reactions fit any of my normal symptom patterns. I do also get these same full-body toxin feeling eating healthier foods. If I stick to "safe" foods (white rice, chicken, pepper, cucumber) I'm okay, but as soon as I try to bring spinach, beans, brown rice, etc. in I get sick like this too. Not sure if it's related, but same symptoms.

I came across the term MTHFR when trying to figure this out. Does any of this ring a bell for anyone? Is it something to look into/any advice?

I am currently supplementing the following every morning:

• 3 g creatine
• 3 g lecithin
• 3 g glycine
• 1 g TMG

Instead of wasting time opening up 4 different containers, measuring 4 different scoops, and opening my mouth 4 different times, wouldn't it be the same if I mix in a big container:

• 300 g creatine
• 300 g lecithin
• 300 g glycine
• 100 g TMG

....then take 10g of this new compound every morning instead?

Would Einstein pe proud of me?

I have been dealing with 24/7 dizziness and tinnitus for 2 years. I’ve been to ENT, had brain MRI, Chiro, etc. I’ve been everywhere. I’ve been on 4 different SSRIs, no relief.

Around Easter of 2025, I had been on Wellbutrin for about 12 weeks. I saw an ad for L-Methylfolate and tried it. I took it before bed, woke up the next day with all symptoms gone. I stopped taking Wellbutrin, and continued to take the L-Methyfolate. For 3 weeks I felt the best I ever had in my life, until everything came back again and been “stuck” ever since.

I’ve tried taking both again and it has not worked. No doctor or anybody has been able to tell me why that worked

I have been recommended to take it, to prevent cold sores and apparently it is also beneficial for endometriosis which I also have.

I always get nervous taking new supplements because you only hear of all the benefits of them but never who shouldn’t take them etc. For example, years ago before I knew about my MTHFR and slow COMT, I was taking regular B vitamins which made me feel absolutely terrible and now I know why. Also creatine, it’s one of the most well researched and recommended supplements however there is some (very minimal) research that shows that creatine is actually terrible for endometriosis and fuels the growth of it. So, I’m always hesitant to try something new.

I tried to do some digging and couldn’t find many red flags about L-Lysine but hearing it from other people always brings more confidence.

Could use some input if you have some please.
Recently I just started getting head aches ear pain head sensitivity/headache weird mood issues and so on
After consistently takeing b for 4ish months consistently every day 12
Around 2,000mcg-3,000mcg because that’s what made me feel good.
Half Aden and half hydroxocobalamin

And b 6 p5p

5 months inconsistently takeing b6 at doses at 20 mg maybe three times a week
Stoped b6 as I started to notice worsening symptoms eye pain heart burn and the symptoms listed above when supplementing this.

Now though when ever I take b12 I get a head ache /sting

Im familiar with b 6 toxicity but I’m not sure wether b6 or b 12 is the root issue b12 labs seem fine and after I take b 12 I get anxious head sting and it calms down then I get like a theraputic effect from it .

I don’t think that’s the case with b6 though it just makes me feel bad now so it seems. Mood and other symptoms^^^
Im still waiting on the labs unfortunately trinity tests for the inactive form of it so I don’t know wether I should even trust the lab work when I get it because I take the active form…. If anyone has two cents on labs and p5p im open minded!

I also supplement other b vitamins in there active form
Low doses riboflavin7mg every day
Niacinamide 30 mg every two days
2,000 mg benfotiamine consistently every day

And sometimes folate though i recently stopped because it would make me feel anxious then I’d stay anxious folinic acid 340% daily value consistently. 1,360 mcg dfe (800mcg)
Was every two days or so for as long as I was takeing the b 6

Pantothenic acid 30mg

For co factors i just recently upped my zinc dose to 25mg
With 1 mg of copper
I take 35mg of iron every other day because I’m border line anemic
Im on my potassium intake and salt
Though salt makes this eye pain worse
Magnesium i try to get from pumpkin seeds
Magnesium glycinate literally started makeing me anxious as soon as all this started
Also vitamin c 500mg-1,000mg depending on the day

I cut out Tudca and amino acids to see if those were the root causes Tudca a couple days ago and amino acids yesterday. As they naturally put me a lil on edge mainly the amino acids but weirdly enough the amino acids stopped me feeling the side effects of Tudca. maybe a lil deficiency in that idk yet

Also I pretty mutch been takeing all of these for 4-5 months now
Except the amino acids and Tudca witch was really on and off until recently when I found out that amino acids stopped the anxiousness with Tudca. Then I went all in consistently for a bit.

Now there’s so many factors I’ve put forth but if any thing im doing wrong that sticks out to you please let me know.

Edit I should add my b12 lvls were in 700s
And that I need to take some of these vitamins twice a day in order just to sleep.