▲ 4 r/MTHFR
MTHFR C677T +/+ but my labs don't make sense... high B12, high folate, high homocysteine, normal MMA. What am I missing?
I've been trying to figure this out for almost 3 years and I honestly feel like I'm going in circles.
My symptoms are:
- severe fatigue (especially mornings)
- brain fog
- low appetite
- anxiety/adrenaline feeling when I wake up
- more anxiety overall
- tingling in my hands and feet
- gas and bloating and burping
- histamine intolerance symptoms
I've already ruled out a few common things:
- Thyroid is normal (TSH + FT4)
- No diabetes
- Kidney and liver function are normal
Here's where I get confused...
Labs (NO B12 or folate supplementation at the time)
- Homocysteine: 12.5 µmol/L
- Serum B12: 1475 pmol/L
- Holotranscobalamin: 500 pmol/L
- MMA: Normal
- RBC folate: 2564 nmol/L
- Vitamin B6 (PLP): 100 nmol/L
- Ferritin: 140 µg/L
- Serum iron: 43 µmol/L
- Vitamin D: 105 nmol/L
- MCV: fluctuates between normal and Elevated (macrocytosis)
- Cortisol**: 3 (low)**
Has anyone here seen a case like this or have any ideas about what mechanism could explain it?
I'm genuinely stuck, so I'd really appreciate any thoughts.
u/Impressive-Mouse-408 — 4 days ago