u/Anxious-Traffic-9548

Title. If you’ve received gifts, what have been some interesting ones?

10-15 years ago, there were a fair few users of longecity who were on selegiline for its purported life-extension and general lifestyle-enhancing effects. Perhaps some of these users lurk here now, since longecity is on life support nowadays. Please use this post to share your experiences. My main curiosities are:

• How long have you been on selegiline and at what dose?
• If you’ve experienced cognitive benefits, what were they and how have they changed (if at all) over time?
• What side effects have you experienced over the years?

10-15 years ago, there were a fair few users of longecity who were on selegiline for its purported life-extension and general lifestyle-enhancing effects. Perhaps some of these users lurk here now, since longecity is on life support nowadays. Please use this post to share your experiences. My main curiosities are:

• How long have you been on selegiline and at what dose?
• If you’ve experienced cognitive benefits, what were they and how have they changed (if at all) over time?
• What side effects have you experienced over the years?

N-(4-fluorophenyl)-N'-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine [ASP2905] is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3) that was originally identified in our laboratory. KCNH3 is concentrated in the forebrain, and its overexpression in mice leads to cognitive deficits. In contrast, Kcnh3 knockout mice exhibit enhanced performance in cognitive tasks such as attention. These data suggest that KCNH3 plays important roles in cognition. Here we investigated the neurochemical and neurophysiological profiles of ASP2905 as well as its effects on cognitive function, focusing on attention. ASP2905 (0.0313 and 0.0625 mg/kg, po) improved the latent learning ability of mice, which reflects attention. Microdialysis assays in rats revealed that ASP2905 increased the efflux of dopamine and acetylcholine in the medial prefrontal cortex (0.03, 0.1 mg/kg, po; 0.1, 1 mg/kg, po, respectively). The activities of these neurotransmitters are closely associated with attention. We used a multiple-trial passive avoidance task to investigate the effects of ASP2905 on inattention and impulsivity in juvenile stroke-prone spontaneously hypertensive rats. ASP2905 (0.1 and 0.3 mg/kg, po) significantly prolonged cumulative latency as effectively as methylphenidate (0.1 and 0.3 mg/kg, sc), which is the gold standard for treating ADHD. Further, ASP2905, amphetamine, and methylphenidate significantly increased the alpha-band power of rats, suggesting that ASP2905 increases arousal, which is a pharmacologically important activity for treating ADHD. In contrast, atomoxetine and guanfacine did not significantly affect power. Together, these findings suggest that ASP2905, which acts through a novel mechanism, is as effective for treating ADHD as currently available drugs such as methylphenidate.

Why YSK: The primary xanthine-type stimulant (the class that caffeine belongs to) in chocolate is theobromine. This comes from its cocoa content, and scales linearly with the “darkness” of the chocolate.

While one ounce of 60% dark chocolate contains a small but appreciable amount of caffeine (20mg), it also contains ~180mg of theobromine. Theobromine is about 1/5th as potent as caffeine and also peaks later after ingestion (~45 minutes vs ~2 hours). Its presence in Yerba Mate is associated with the smoother, longer acting effects of it relative to coffee. By rough comparison, the “caffeine equivalent” of the aforementioned 60% dark chocolate would be ~56mg, roughly equivalent to a shot of espresso (though felt over a longer period of time).

For people with a low caffeine tolerance, this can produce a noticeable stimulating effect! Personally, as someone who doesn’t drink caffeine at all, even a hot chocolate is enough to cause some difficulty faking asleep. Like many, I thought this was impossible given the low caffeine content, but when factoring in the theobromine content, the effect is reasonable.

This questionnaire compares your responses to the averages of a sample of 1800 CFS/ME patients. Posting here to share and gather this community’s thoughts.