r/NooTopics

Now, I don’t smoke weed. I’ve taken every single drug, substance, supplement, nootropic, steroid, research chemical, analogue etc you can think of. Weed is one of the few that always made me a little bit anxious for some reason.

I have a condition (congenital) where I could get a medical card easily. Two of my family members hit their THC pens daily, 24/7.

Now, I’m around 30 years old. Growing up, weed was either “The Devil’s Lettuce” or it was the end all/be all cure to every disease possible.

The newer generation (let’s say Gen Alpha maybe?) does not see weed as God’s ultimate cure. When did that happen? HOW did that begin to happen as it started to become legalized in more areas across the USA and across the world?

I’ve been in and out of the hospital for brain things I was born with, so my memory can be a little shoddy.

What are y’all’s opinions and thoughts on when this sudden POV change happened?

I got the spray bottle from everychem (the spray), its infront of me right now but im afriad it will trigger something or make me go crazy ive just had bad experiences with pharmaceuticals and have anxiety.

Idonno make it just makes me worried that al go crazy.

Long time weed smoker.. never felt so bad. Someone recommended that I ask here about nootropics that could help with withdrawals, brain recovery.

I can’t buy crypto so anywhere I can with debit card? And to the UK? I know you can buy off Amazon but idk what’s decent.

I’m dealing with my second major flare in about 10 days of what feels like sensorimotor OCD / hyperawareness OCD.

The obsession is saliva and swallowing awareness. I’m not producing too much saliva. The issue is that I become hyperaware of normal saliva generation and swallowing, and once my attention locks onto it, I can’t stop noticing it. During a flare, it feels like every conscious moment is affected by the awareness.

The fear is not really about saliva itself. It is more existential: “What if I can never live in the moment again because my attention keeps coming back to this?” When I’m not in a flare, it can disappear completely, but when I’m in one, it feels impossible to believe it will ever fade.

I know the standard treatments for OCD are ERP/CBT and medication like SSRIs. I’m not trying to replace medical care, and I’m planning to talk to a doctor. But I’m curious whether anyone here has found any nootropics or supplements that helped with the specific “stickiness” of obsessive attention, somatic hyperawareness, rumination, or intrusive thought loops.

Things I’m especially curious about:

• NAC
• Inositol
• Magnesium glycinate or threonate
• L-theanine
• Glycine
• Sarcosine
• Agmatine
• Ashwagandha
• Lithium orotate
• Anything affecting glutamate, anxiety, or compulsive rumination

For people with OCD, sensorimotor OCD, somatic obsessions, health anxiety, hyperawareness, or sticky intrusive thoughts:

Did any supplement/nootropic actually reduce the stickiness of the obsession?

Did it help the anxiety/panic around the awareness, the awareness itself, or both?

How long did it take to notice anything?

What dose did you use?

Did anything make it worse?

Were there any side effects, withdrawals, rebound anxiety, insomnia, libido issues, or emotional blunting?

I’m not looking for medical advice, and I know supplements can affect people very differently. I’m mainly looking for personal experiences and things worth discussing with a doctor, especially from people who understand OCD-style attention loops rather than general anxiety alone.

Do things that increase Dopamine/noradrenaline synergize well with things that increase Acetylcholine? what's your experience (Focus, motivation, mental clarity)?

Can someone explain to me when I take stimulants or anything that increases both norepinephrine and dopamine and why I only interpret the noradrenergic effects and barely interpret the dopaminergic
effects at all? Every stimulant does this to me, even caffeine nowadays just makes me wired, anxious and jittery and before it made me feel happy and gave me burst of excitement.

Why do I have this reaction? I only feel the fight and flight symptoms and wiredness, jitteriness and independent doom and anxiety. But no euphoria, reward or happy feeling at all. Is there a scientific explanation for this? Does my body just prefer norepinephrine over dopamine or what?

Can anyone tell me the main effects and differences of the different racetams, especially phenyl, faso, ani and prami. Also how they can be mixed and how much choline in the form of alpha GPC and/or CDP choline is needed? I like a daily portion of supplement need’s pre focus+ with my racetams. Also how important is fat for ani and prami? I take faso sublingual..

The scientific reviewers basically said there just isn’t enough solid human clinical data to show these peptides are safe or effective for the ways people want to use them. Most of them aren’t well characterized chemically(purity, stability, impurities, or how they tend to clump together).

They highlighted a real risk of immune reactions, especially with injectables or nasal forms when compounded, plus general worries about quality control and formulation in a pharmacy setting. They also noted that for some of the conditions being targeted, there are already approved treatments available.

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BPC-157: Only one small, limited human trial for ulcerative colitis, almost no good data on most of the common ways people use it (they were particularly wary of nasal), and the exact mechanism is still pretty unclear. One Human trial by patent holder was never released.

KPV: Very limited human data for the proposed uses or routes; little information on cream or gel formulations.

TB-500: Very limited human data

MOTS-c: Very limited human data

Emideltide/DSIP: Has the longest research history, but the studies are mostly small, old, and inconsistent. Side effects include drops in blood pressure and nausea.

Semax: Mostly relies on animal data, human studies are old and from Russia. Not up to western regulation.

Epitalon: Lacking strong studies for insomnia via the proposed method, plus a theoretical cancer risk tied to how it affects cell growth mechanisms. Telomere extension could allow malignant cells to survive and turn cancerous. Though animal studies actually showed reduced tumor incidence and metastasis.

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Note: These are no longer banned, you can get these peptides compounded at specific pharmacies. However, these peptides are not FDA endorsed nor approved in any way.

The FDA is technically right based on the lack of data. Proceed at your own risk.

More: [FDA panel on peptides will include experts who promote the unproven chemicals favored by RFK Jr.

](https://www.pbs.org/newshour/health/fda-panel-on-peptides-will-include-experts-who-promote-the-unproven-chemicals-favored-by-rfk-jr)