u/Aggressive-Guide5563

So I was on 150 mg Wellbutrin for like three months and it wasn’t doing so much for me and I was still having bad anxiety from it. So me and my GP decided to add 10 mg Prozac on top of it. Big mistake. I got the worst panic attack ever yesterday and today. I swear I felt really overstimulated in a bad way. Almost like the feeling of being overcaffeinated. It was horrible. I was so scared something bad was going to happen. I haven’t had any caffeine at all. I removed all caffeine completely.

But today it was horrible. Massively overstimulated when taking them together. But I highly suspect it’s the Prozac because I wasn’t feeling this overly stimulated on Wellbutrin 150 mg all alone. I got side effects like hot flashes, burning sensations, heart palpitations, headaches, increased sweating, muscle stiffness, diarrhea and sleep disturbances. And I just woke up with the feeling of dread. Then I took my pills and immediately got a really bad panic attack and just felt overstimulated and overexcited in a really bad way. I went to the psychiatric ER immediately and they did some tests and then I talked to a nurse and she said that these side effects are probably the startup of Prozac and she told me to contact my GP as soon as possible and tell them about this. She told me if it gets worse and I can’t get in contact with my GP, they told me I can come back again.

I swear I just want to quit this shit. Prozac made me teen times worse. I was so much better off taking Wellbutrin all alone. Prozac made me so much worse I can’t describe it. 300 mg Wellbutrin was the only thing ever helping my depression but of course I couldn’t tolerate it anymore because it overstimulated me in various ways. Nothing else helped me. I’m devastated and I’m highly disappointed. Prozac worked for my anxiety in the past. But now I had a bad reaction to it. I don’t know what to do anymore. No antidepressants work for me I always have bad reactions to them.

So I was on 150 mg Wellbutrin for like three months and it wasn’t doing so much for me and I was still having bad anxiety from it. So me and my GP decided to add 10 mg Prozac on top of it. Big mistake. I got the worst panic attack ever yesterday and today. I swear I felt really overstimulated in a bad way. Almost like the feeling of being overcaffeinated. It was horrible. I was so scared something bad was going to happen. I haven’t had any caffeine at all. I removed all caffeine completely.

But today it was horrible. Massively overstimulated when taking them together. But I highly suspect it’s the Prozac because I wasn’t feeling this overly stimulated on Wellbutrin 150 mg all alone. I got side effects like hot flashes, burning sensations, heart palpitations, headaches, increased sweating, muscle stiffness, diarrhea and sleep disturbances. And I just woke up with the feeling of dread. Then I took my pills and immediately got a really bad panic attack and just felt overstimulated and overexcited in a really bad way. I went to the psychiatric ER immediately and they did some tests and then I talked to a nurse and she said that these side effects are probably the startup of Prozac and she told me to contact my GP as soon as possible and tell them about this. She told me if it gets worse and I can’t get in contact with my GP, they told me I can come back again.

I swear I just want to quit this shit. Prozac made me teen times worse. I was so much better off taking Wellbutrin all alone. Prozac made me so much worse I can’t describe it. 300 mg Wellbutrin was the only thing ever helping my depression but of course I couldn’t tolerate it anymore because it overstimulated me in various ways. Nothing else helped me. I’m devastated and I’m highly disappointed. Prozac worked for my anxiety in the past. But now I had a bad reaction to it. I don’t know what to do anymore. No antidepressants work for me I always have bad reactions to them.

So I was on 150 mg Wellbutrin for like three months and it wasn’t doing so much for me and I was still having bad anxiety from it. So me and my GP decided to add 10 mg Prozac on top of it. Big mistake. I got the worst panic attack ever yesterday and today. I swear I felt really overstimulated in a bad way. Almost like the feeling of being overcaffeinated. It was horrible. I was so scared something bad was going to happen. I haven’t had any caffeine at all. I removed all caffeine completely.

But today it was horrible. Massively overstimulated when taking them together. But I highly suspect it’s the Prozac because I wasn’t feeling this overly stimulated on Wellbutrin 150 mg all alone. I got side effects like hot flashes, burning sensations, heart palpitations, headaches, increased sweating, muscle stiffness and sleep disturbances. And I just woke up with the feeling of dread. Then I took my pills and immediately got a really bad panic attack and just felt overstimulated and overexcited in a really bad way. I went to the psychiatric ER immediately and they did some tests and then I talked to a nurse and she said that these side effects are probably the startup of Prozac and she told me to contact my GP as soon as possible and tell them about this. She told me if it gets worse and I can’t get in contact with my GP, they told me I can come back again.

I swear I just want to quit this shit. Prozac made me teen times worse. I was so much better off taking Wellbutrin all alone. Prozac made me so much worse I can’t describe it. 300 mg Wellbutrin was the only thing ever helping my depression but of course I couldn’t tolerate it anymore because it overstimulated me in various ways. Nothing else helped me. I’m devastated and I’m highly disappointed. Prozac worked for my anxiety in the past. But now I had a bad reaction to it. I don’t know what to do anymore. No antidepressants work for me I always have bad reactions to them.

I was on 300 mg Wellbutrin for several years for my depression. It worked tremendously for my energy, motivation, cognition and brain fog and overall functioning and was the only thing ever helping my depression. But unfortunately in the end I couldn’t tolerate it anymore because it started to cause horrible anxiety and insomnia that started to interfere with my life in many ways. It also started to give me weird side effects I never used to get from it before and it just started to make me feel extremely overcaffeinated, which again never experienced that from it before. And once these side effects escalated I decided to drop back the dose to 150 mg.

Now I’ve been on 150 mg for more than three months now and I’ve already noticing my depression has worsened significantly and the racing thoughts and suicidal thoughts have come back all over again. I lack energy and motivation to do things. I’ve lost interest in things that I liked before. And I have lost almost all of my cognition that I had at 300 mg and the brain fog has started to come back. And I overall feel just so much worse emotionally and mentally than I did several months back when I was on 300 mg.

Now I did have an appointment with my GP recently and I told her all about this and she was like at first suggesting to go back to 300 mg all over again all by itself and then we would reassess in a few weeks again. But then I told her the reason I backed off the dose from 300 mg to 150 mg in the first place is because it started to overstimulate me and it caused horrible anxiety and insomnia. I told her it wasn’t because it wasn’t working anymore. I just couldn’t tolerate it anymore. I told her if I go back to 300 mg I might still need a med to remove the anxiety and insomnia.

And after that she was like we are putting Prozac back. I told her that I used to take 300 mg Wellbutrin and 20 mg Prozac for two years and that I experienced none of the insomnia or any of these side effects when I took it with Prozac. I told her that I think my body overall tolerated Wellbutrin better alongside Prozac. So that’s why her next suggestion was to put Prozac back. But then she said I only allow you to keep 150 mg Wellbutrin and then add 10 mg Prozac and then we reassess in a few weeks. Because when she searched on her computer she said combining Wellbutrin and Prozac can cause serotonin syndrome and then I told her I took them for literally two years with no issues at all. And when she said I can only have 150 mg Wellbutrin and 10 mg Prozac, I asked her can I never go back to 300 mg Wellbutrin and 20 mg Prozac again? And she just rolled her eyes and was like not now, It will be too much meds all at once. And I told her I completely understand that.

I mean I understand why she is being cautious and wanting to be more careful while introducing something else. But what if the next time I come back to her again and I tell her like it’s not working for me and I really want to return to the combination I used to take before, eventually if I can tolerate it. What if she turns me down and says I won’t prescribe this combination? I mean what do I do then? Because I’m 💯 certain the next time I ask for it, I know she will say no based on what she told me now. And if so do you think I should just get a second opinion? I know this whole text got way too long but I had to explain everything.

I started 10 mg Prozac today on top of 150 mg Wellbutrin mainly for anxiety. Today I had a panic attack and I feel slightly overstimulated. How long does it take until Prozac stops being stimulating? Is it several weeks? Because if it’s going to be like this all the time I don’t think I will make it. I used to take 300 mg Wellbutrin and 20 mg Prozac together for two years with no issues. But now I wanted to add Prozac back mainly because Wellbutrin all alone is making my anxiety worse. I don’t want to feel overcaffeinated and not getting any sleep at all.

I have extremely high baseline norepinephrine levels and I’m wondering if there are any supplements beside melatonin and magnesium that can reduce excess norepinephrine? The symptoms I have everyday is headaches, dizziness, vertigo, heart palpitations, rapid heartbeat, panic attacks, hot flashes, burning sensations, insomnia and sleep disturbances, muscle stiffness, hypervigilance etc.

I have extremely high baseline norepinephrine levels and I’m wondering if there are any supplements beside melatonin and magnesium that can reduce excess norepinephrine? The symptoms I have everyday is headaches, dizziness, vertigo, heart palpitations, rapid heartbeat, panic attacks, hot flashes, burning sensations, insomnia and sleep disturbances, muscle stiffness, hypervigilance etc.

So I’m on 150 mg Wellbutrin XL currently and while it helps energy, motivation, fatigue, brain fog and cognition, my anxiety and GAD is pretty bad. So I’ve thought about adding a low dose of Prozac to start with maybe like 10 mg at first. And I know Prozac can be quite activating when you first start it and that you can get increased anxiety and insomnia at first. I’m mostly worried about the adjustment phase because I’ve felt overcaffeinated from Wellbutrin all by itself and I don’t want to get that when putting Prozac.

Is there anyone who has been on Wellbutrin at first and then added Prozac and how was your experience? Did you get increased anxiety and insomnia at first and how did you tackle it? Did you feel overcaffeinated or overstimulated with that combo at first? And did you experience nausea and lack of appetite at first ? And how did you tackle that? And how long was the initial adjustment period before you started to feel like less anxious and had less racing thoughts?

Like the title says. I took it for a very long time and it destroyed me long term completely. I got weird nasty autonomic side effects from it like frequent thirst, frequent urination, dry mouth, dizziness, vertigo, headaches, hot flashes, burning sensations, increased sweating, heart palpitations, rapid heartbeat, chest discomfort, horrible insomnia and sleep disturbances, facial twitching, muscle stiffness , hypervigilance, you name it. All kinds of dirty side effects related to its noradrenergic effects.

But when I try to go off of it I get horrible withdrawal symptoms like extreme fatigue that never wants to go away, brain fog, no energy or motivation to do anything or even basic tasks, feeling like my whole body is slow and I can’t function properly without it. I just lie down in my bed the whole day just staring at the wall because of the extreme fatigue and brain fog and I just sleep all the time. And I lose all of my cognition and just become useless to society.

But when I’m on it, it causes nasty autonomic side effects, worsens my anxiety and causes panic attacks and physical alarm symptoms. And it causes horrible insomnia and sleep disturbances. One time I was awake for two nights straight without any sleep and I lost weight because of the lack of sleep. I felt like a skinny insomniac on it.

I completely messed myself up ever starting this. I can never go off of it because of horrible withdrawal symptoms, but when I’m on it I feel much worse

Is there anyone who has fasted on this med? And which dose are you on? Did you feel fine doing it or did you get sick? I’ve wanted to fast on it but I feel extremely like sick If I try to do it. I mean I have electrolytes and drink water but still I get dizzy and just get adrenaline surges when I go for too long without eating anything. Especially when my blood sugar just gets slightly low I get severe dizziness, vertgio, balance issues, headaches, increased sweating, my heart races and I start to feel extremely sick, like I’m about to faint or something.

So I’m wondering if anyone else had success with fasting on this med?

I was on Wellbutrin for a very long time mainly because of undiagnosed SCT and executive dysfunction issues. Unfortunately the dose that I need to target my SCT and executive dysfunction I couldn’t tolerate it anymore because of weird autonomic side effects and because it caused severe anxiety and horrible insomnia. Backing off the dose solved some of the side effects but I’ve lost all of my cognition and my brain fog is back and anxiety is still bad.

So now I’m wondering about alternative meds for SCT and executive dysfunction? My main issue with Wellbutrin overall was that I felt like it gave me slight motivation and drive to do things, but I could never put it out to good use at all because the physical anxiety and jitteriness was too distracting and the frequent thirst and dry mouth was also extremely distracting and annoying and drove me almost nuts. My whole experience with it was getting distracted by anxiety and side effects and monitoring my body constantly all the time, which made my GAD spike and the constant panic attacks too was really distracting. I just felt like it made me mostly restless and anxious but with no motivation or drive to do anyhing. And I felt that it was just too overwhelming for me. It’s like at 150 mg I’m awake and alert and I have the physical energy but I can still stare at the walls for hours doing nothing.

Like the title says. Why are nicotine and caffeine the only things to help my depression, apathy, avolition and anhedonia?

I’ve tried several different antidepressants of all flavors, including SSRIS and Wellbutrin, you name it and none of them worked for me and just made me worse off. SSRIS just made me more numb, apathetic and complacent. And caused emotional blunting and made things less interesting in life and they all made me so tired all the time. Wellbutrin on the other hand was not as bad as SSRIS though, but still it didn’t work for me. Wellbutrin just made me feel incredibly anxious, wired, tense, restless and confused all the time. So just anxiety, anxiety and anxiety with Wellbutrin and horrible insomnia. Wellbutrin should be named an anxiety inducing drug I think. But did not help apathy and anhedonia. It only really helped with fatigue and avolition. I think Wellbutrin just goes too aggressively on norepinephrine and that caused me to be in that wired and tired and confused state all the time. And overall it just me go into panic states all the time.

So since antidepressants do nada for me. I have to rely on heavy amounts of nicotine and caffeine to help my depression, even though they’re not sustainable, I know that and can cause rapid tolerance. But I have no other choice, since every doctor and psychiatrist I’ve been to don’t want to help me out and always tell me you have to find the motivation yourself, bla bla bla. They don’t understand how it suffering from severe apathy and anhedonia. They just think it’s so easy living like this everyday and being unable to function properly without heavy amounts of caffeine and nicotine. So since they don’t care, I have to self medicate. That’s it.

Caffeine and nicotine do the job temporarily, even though it’s not sustainable long term. But I can’t help it since I don’t get any help for it. And they refuse to take me back. Antidepressants don’t work for me and I’ve told them that several times. But they always want to give SSRIS to me or Wellbutrin. No other choices or options. They’re never open minded either. This is all I have to say folks!

I need something to give me energy and motivation and to help with productivity and to give me attitude and alertness. Would a norepinephrine releasing agent work for that? Does it give any euphoric feeling whatsoever? Or is mostly alertness and wakefulness and attitude you get from it?

Like the title says. I will be self medicating my depression because no one wants to help me. They refuse to take me back despite telling them my current med regimen isn’t working.

I’ve been on Wellbutrin for almost five years and 300 mg was working for my depression and kept my depression stable for a long time until I couldn’t tolerate it anymore. It started to overstimulate me in various ways I couldn’t tolerate it anymore. It caused weird side effects I never used to get from it before and I developed horrible insomnia and was chronically overactivated from it all the time. I backed off the dose to 150 mg a little bit more than two months and its not doing anything for me at all. My depression has gotten significantly worse since backing off the dose and my brain fog and cognition has worsened. I have no energy or motivation to do anything anymore. My suicidal thoughts have reached scary levels.

I see no other way out than to self medicate. I can’t do this anymore. This is the only way out or I might hurt myself. Because I honestly don’t care what happens to me. I just want some relief from this. They told me they have nothing else to offer. That means I have to do this on my own. I know self medicating is a bad idea. But if no one wants to help me than I have no other choice. I’m suffering everyday and it’s just getting worse for everyday that goes. Just have the thought of not living anymore, that’s it. I hate myself and I hate everything.

Is there someone who tried different generics and then brand name? Was there any difference regarding mood, motivation, energy levels etc? Did you find that brand name worked better for you? And also did brand name have less side effects? I want to hear your experience with being on generic and then switching to brand name.

Are there any pure serotonin releasing agents? I would like to know some examples. I’m interested in trying it and see how it’s like. I need to be more calm and content because I’m constantly too anxious, stressed, restless and wired all the time and I feel like I’m constantly climbing the walls. I think a serotonin releasing agent would kind of clamp down that a little bit. So anyone who has any ideas?

Can someone give me an example of any CYP2B6 inhibitors? Is there like a supplement for this? The reason is that I take Wellbutrin and I react very well to the parent drug, which favors dopamine over norepinephrine. The parent drug I can tolerate fine. But I react very badly to Hydroxybupropion, which is more of a potent NET blocker. Hydroxybupropion gives me symptoms of overstimulation and with that side effects clearly related to overactivation of the sympathetic nervous system and those side effects are frequent thirst, frequent urination, dry mouth, severe dizziness and vertigo, hot flashes, burning sensations, severe headaches and migraines, muscle stiffness, heart palpitations, rapid heartbeat, insomnia and sleep disturbances, facial twitches, jitteriness, hypervigilance etc.

I honestly don’t like how Hydroxybupropion makes me feel like. But because of lack of options I’m still stuck on Wellbutrin because I have SCT and executive dysfunction. And every time I go off of it I feel unable to function properly and I have no energy or motivation to do anything and my brain fog comes back and I lose all my cognition. That’s the reason why I’m still taking it even though it might not be the right med for me.

Since I can’t switch meds right now. I was wondering if using CYP2B6 inhibitors would work and prevent that conversation to Hydroxybupropion? I would like to have motivation and focus but without the anxiety and hypervigilance. So I’m wondering if this is possible?

I’ve been on Wellbutrin for almost five years and it’s the only antidepressant that ever did anything for my depression. I suspect it was the weak dopaminergic effects that helped my depression in the first place. And the reason why I’ve been on it for such a long time is that it helps my SCT and executive dysfunction tremendously and helps me function better on a daily basis.

But unfortunately with long term use it started to overstimulate me in various ways I couldn’t tolerate the original 300 mg dosage that helped my depression for a very long time. It started to give me really bad anxiety, horrible insomnia and other weird nasty side effects I never used to get from it before. And when those side effects and the overstimulation escalated I had no other choice then to back off the dose to 150 mg.

Now I’ve been on 150 mg for little more than two months and I’ve already noticed my depression has worsened a lot since backing off the dose. I don’t have as much motivation to do things anymore and I’ve lost interest for things that I used to like. I think 150 mg isn’t controlling my depression well all on its own. I do think 150 mg is much more tolerable, but I just don’t think it’s helping that much at all. The side effects though did lessen since backing off the dose. But they did not completely disappear either, they just lessened in intensity.

At first it was helpful for apathy, avolition and anhedonia. But later on it became a killer anxiety provoker. Obviously dopamine did not fail from the first place. It became too much noradrenergic overactivation over time. And that explains why it feels like a completely different drug to me than five years ago. Five years ago it felt highly motivating, rewarding and gave me anticipation and excitement. Nowadays it’s just anxiety and panic attacks and deadness. And when I did my research I found out that the parent drug is more active when you first start it. That explains the effects I got early on. But later on when the metabolites build up which are highly noradrenergic the opposite happens. Hydroxybupropion which is the major active metabolite is a very potent NRI. That explains why I’m having all these side effects now and why I just feel overcaffeinated when taking it.

Wellbutrin was not the wonder drug I thought it would be. Now I’m out of options. Nothing ever helped me like Wellbutrin from the beginning. Now my anxiety is so bad I can’t take it anymore. I think I have to call urgent psychiatric clinic or I don’t know what will happen. This anxiety is just killing me right now.

I’ve been on Wellbutrin for almost five years and it’s the only antidepressant that ever did anything for my depression. I suspect it was the weak dopaminergic effects that helped my depression in the first place. And the reason why I’ve been on it for such a long time is that it helps my SCT and executive dysfunction tremendously and helps me function better on a daily basis.

But unfortunately with long term use it started to overstimulate me in various ways I couldn’t tolerate the original 300 mg dosage that helped my depression for a very long time. It started to give me really bad anxiety, horrible insomnia and other weird nasty side effects I never used to get from it before. And when those side effects and the overstimulation escalated I had no other choice then to back off the dose to 150 mg.

Now I’ve been on 150 mg for little more than two months and I’ve already noticed my depression has worsened a lot since backing off the dose. I don’t have as much motivation to do things anymore and I’ve lost interest for things that I used to like. I think 150 mg isn’t controlling my depression well all on its own. I do think 150 mg is much more tolerable, but I just don’t think it’s helping that much at all. The side effects though did lessen since backing off the dose. But they did not completely disappear either, they just lessened in intensity.

At first it was helpful for apathy, avolition and anhedonia. But later on it became a killer anxiety provoker. Obviously dopamine did not fail from the first place. It became too much noradrenergic overactivation over time. And that explains why it feels like a completely different drug to me than five years ago. Five years ago it felt highly motivating, rewarding and gave me anticipation and excitement. Nowadays it’s just anxiety and panic attacks and deadness. And when I did my research I found out that the parent drug is more active when you first start it. That explains the effects I got early on. But later on when the metabolites build up which are highly noradrenergic the opposite happens. Hydroxybupropion which is the major active metabolite is a very potent NRI. That explains why I’m having all these side effects now and why I just feel overcaffeinated when taking it.

Wellbutrin was not the wonder drug I thought it would be. Now I’m out of options. Nothing ever helped me like Wellbutrin from the beginning. Now my anxiety is so bad I can’t take it anymore. I think I have to call urgent psychiatric clinic or I don’t know what will happen. This anxiety is just killing me right now.

So I’ve been on it for almost five years now. It’s the only antidepressant that ever did anything for my depression and that’s the reason why I’ve been on it for such a long time and also that it helps my SCT and executive dysfunction and helps me be more functional on a daily basis. Unfortunately I do have noticed this year and last year that it has started to wear off a little bit. I’ve noticed that it doesn’t seem to have the same impact on my mood anymore. And I’ve noticed the burst in motivation and anticipation it used to give me just isn’t there anymore.

So if anyone else has had the same experience that Wellbutrin used work very well for them initially but that it stopped working for them. Did you just switch to something else or what did you do about it? I’m honestly struggling with finding an alternative med. There isn’t any other antidepressant out there like Wellbutrin. Wellbutrin is quite unique on its own and that’s why I’m struggling with finding something else that can work as well for me. That’s the reason why I’m still stuck on it despite that it isn’t working as well for me anymore. If anyone found an alternative med I would like to hear about it.