r/Wellbutrin_Bupropion

Potatoes - CYP2D6 - Medication
▲ 48 r/Wellbutrin_Bupropion+2 crossposts

Potatoes - CYP2D6 - Medication

Hi all.

Just sharing something that I discovered that might touch on some histamine issues.

I did a full genetic testing and discovered that I’m CYP2D6 null (no enzime present). This enzyme is responsible for about 30% of all medications, from psychiatry, to blood pressure, etc and causes different reactions with a lot of medication, some you cannot convert to the active substance (cannot use codeine or tramadol because my body can’t convert it) or can have much more blood substance concentration that what it should be. This might be a future post.

The thing that was more surprising, was potatoes. 🥔

Potatoes have a toxic substance called solanine. It is present mainly on green potatoes, the skin, sprouts, and eyes. You should also not use any the water when cooking them, as the water gets contaminated.

Being null (like me) actually means that the substance accumulates to a staggering +1887% and in poor metabolizers +74% when compared to normal metabolizers. Link One thing quite important here, besides the genetic side: There are many medications, that actually change the enzime activity because they inhibit it. As an example: Bupropion (Wellbutrin), Fluoxetine (Prozac), Paroxetine (Paxil), Quinidine, Terbinafine

What that means: That there is a likely chance that nulls, are in a chronic toxic exposure for that substance since birth or from the moment that they start taking one of the inhibitors, and that probably translates to sustained chronic inflammation, where it is hard to actually pin point what is happening. In my personal case, I have spent all my life trying to discover what foods were causing me problems, mood swings, etc.

So it might be good to at least know what is your status, or if the medication you are taking is actually inhibiting the enzime, as potatoes become an issue and might be triggering MCAS or histamine crises if the values are too high. In my personal case I will stop eating potatoes and products dedicated from potatoes.

Hope this helps.

u/diogopacheco — 7 hours ago

Wellbutrin is making me feel crazy!

Hello! New to Reddit… but I have been on Wellbutrin for about 3 weeks now (but also there were some days that I didn’t take it..) I’m on the extended release 150mg. I feel extremely panicky, anxious and I am very weepy. I also have been feeling some vertigo/dizziness the last few days (forgot to take it with me on a trip and didn’t take it for 4 days). I feel like I’m going insane. My anxiety is all the time and peaks at night, where I often feel like I’m constantly on the verge of a panic attack (impending doom, hot flashes, fast heart rate). My doctor is encouraging me to stick with it, and I read that with this med it gets worse before it gets better? Has anyone else experienced this?

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u/Personal-Hippo2114 — 9 hours ago

20 days on 150mg. No effect.

First week I had headaches, but now on day 20 those side effects are gone, but I don’t feel any different.

I’m still obviously depressed, ruminating and worried about what to do with my life.

I know you have to wait 4-6 weeks, and I will finish the course, but has anyone else been in the same situation? Did it end up working out eventually?

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u/throwawayboy2200 — 1 day ago
▲ 3 r/Wellbutrin_Bupropion+2 crossposts

Heart palpitations worse

Today has been 3 weeks since starting 150mg of Wellbutrin xl and the past couple days I noticed my heart palpitations were getting worse. Tonight being the worst with the skipping beats and pounding sensation every few minutes. I have a few things wrong with my heart (inappropriate sinus tachycardia, occasional PVCs and PACs and a chronic pericardial effusion) that I’ve been diagnosed with for years. I also think it’s important to note that I have hypothyroidism (Hashimotos) and my pcp increased my levothyroxine dose at the same time I started the Wellbutrin to see if that helped me lose weight. I stopped the levothyroxine 2 days ago because I thought the palpitations were from that since the last blood draw was already showing borderline low TSH before the increased dose. I also have cut out caffeine since starting the Wellbutrin but did have a soda today so I’m not sure if that’s contributing to it or not. Now I have an ache in my back/shoulders but normal O2 and pulse at 55-60. I really don’t want to go to the hospital since I’m a frequent flyer there but it’s not getting any better and I’m really trying everything I can possibly think of to relax and it’s not helping. My cardiologist knew I started taking this when I called to report I was cutting my metoprolol dosage in half due to extremely low blood pressure and heart rate once starting the Wellbutrin (had no idea it increased the amount of metoprolol in my blood stream and was in the hospital for that as well). So I feel like if she was worried about me taking it she would’ve said something, right? I’ve seen a few others post about heart palpitations while on Wellbutrin but nothing really relating to my situation. Any advice or similar experiences are welcome. I have a follow up with my pcp next week and I’m logging my symptoms until then.

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u/Agitated_Quiet993 — 23 hours ago
▲ 2 r/Wellbutrin_Bupropion+1 crossposts

Is the generic quality issue mainly around the extended release versions (SR/XL)?

I just started taking Wellbutrin a couple of weeks ago and got the generic from ScieGen. So far it actually seems to be working well for me, but after reading a lot of posts here about people having very different experiences depending on the manufacturer, I’m getting a little nervous about the whole generic roulette thing.

Is this mainly an issue with the extended release versions (SR/XL) or are people noticing the same kinds of differences with the generic IR version too?

Curious to hear people’s experiences. Thanks!

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u/dova-dog — 23 hours ago

Bupropion and Trazodone? What has your experience been?

Hi guys, my psychiatrist prescribed Trazodone 50mg to take at night because she thinks my mind is running and I need at least 7 hours of uninterrupted sleep (her words not mine). She told me to cut it in half the first 3 days then take a full one once a day at night(I just cut all of them in half because everyone says it makes you so groggy).

For those who take the two what have you noticed or what was your experience with it.

I take:
Bupropion 150 mg XL

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u/Dizzy-Fault-6250 — 1 day ago

Vivid dreams?

Hi I just started Wellbutrin XL 150MG.
I take it with 50MG of Pristiq because I am trying to switch over. So far this medication isn’t bad, but at night I have vivid dreams and I’m kinda scared to sleep tonight. This will be my 2nd night. Does the dreams go away?

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u/Paranormalgirlpodd — 23 hours ago

Side effects go away?

Have an 19 yr old starting on the generic. 2 weeks in and super bummed it’s not going well. 150mg of SR

Thinking we need to give it at least a full month or 2 to see how it goes but has had :

-irritability which i read is common
-fatigue and not motivated. Which is opposite of what we were hoping for
-brain fog and kind of numb.

Hope this can change but wanted to see any positive stories where things started as such but turned around Thx

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u/rich4j1619 — 1 day ago

When do I start to notice any slight difference ?

Was on escitalopram for a year and it made me gain weight and overall just wasn’t happy with it. Recently switched to 150mg Wellbutrin for 7 days and then have been on 300mg for the past 2 weeks. I don’t really notice anything. When did you start to notice a difference?

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3 years in and I found the best combo

300mg XL Bupropion in the morning, 25mg Hydroxyzine about 2 hours before bed, and 60mg Propranolol as needed.

Bupropion relieved my depression with little to no side effects. Hydroxyzine helped with my anxiety, insomnia, and severe allergies, while propranolol helped keep me physically calm throughout the day.

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u/Fast-trader — 2 days ago

Help. Just started Wellbutrin & have a drinking event this weekend

Ok I apologize in advance. I understand the stupidity of my ways & my question & I am aware of all risks involved. Started on Wellbutrin 150 10 days ago for adhd. I was not aware of all of the potential side effects with alcohol. I rarely consume alcohol, but do so socially at concerts/ festivals and usually consume copious amounts lol. Have a festival this weekend & know that alcohol among possibly other things may be consumed. Considering stopping Wellbutrin 3 days before as I don't believe much is in my system & to possibly mitigate the side effects. Any advice?

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u/Opposite_Pea — 2 days ago

ADHD, Wellbutrin (450mg) + Atomoxetine (40mg) combo.

Hi everyone, I’m 18 years old and I have severe ADHD. For years, the only thing that motivated me or got me moving was pure stress and anxiety. As a result of this chronic stress, I eventually ended up battling depression, anxiety, and severe anhedonia. I also suffered from maladaptive daydreaming to the point where I felt completely detached from reality.

Three months ago, I started a combination of Wellbutrin (Bupropion) and Atomoxetine. Here is how my dosage progressed month by month:

  • Month 1: 150mg Wellbutrin + 18mg Atomoxetine
  • Month 2: 300mg Wellbutrin + 25mg Atomoxetine
  • Month 3 (Current): 450mg Wellbutrin + 40mg Atomoxetine

Every monthly dosage increase has triggered significant changes in me. To be honest, I didn't want to scale up Wellbutrin this fast. However, whenever we increase the Atomoxetine dose, I experience a highly uncomfortable, crushing anhedonia/emotional blunting. To counter this, I kept asking my doctor to bump up my Wellbutrin dose.

But here is my current dilemma: 40mg of Atomoxetine is still not enough for me. My executive function is still impaired, and I'm struggling to get things done. I desperately need to increase my Atomoxetine dose to function, but I am terrified of dealing with worse anhedonia. Plus, I am already at the maximum dose of Wellbutrin (450mg).

Has anyone else experienced this while on this combo? How can I overcome this wall of anhedonia without sacrificing my executive function? I would love to hear your experiences and insights.

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u/Vexyle — 1 day ago

Holy cow name brand is expensive

What do any of you pay for name brand? Walmart says $3000 for 30 days 300xl. I've gotten 3 different generics in the last three months. Some have coating, some don't. Doesn't feel like they're working the same, but I can't afford $3k.

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u/Humble-Assist6971 — 1 day ago

Upping dose and I am feeling worse

A few weeks ago, my PCP doctor changed my dose from 150mg to 300mg because I was still dealing with a lot of tiredness. I definitely have been having more energy, but I’m also experiencing some negative side effects I never had when starting on 150mg.

I have been so irritable and my emotional resilience is at such a low. I keep snapping at my partner and feeling such a sense of doom. I definitely struggle with anxiety and OCD, but it doesn’t feel like it’s exacerbated that side of my mental health. It’s more in anger, feeling overwhelmed, hopelessness, and being unable to bounce back even after something super small.

I really appreciate having more energy and had felt like my 150mg dose had been giving me a little extra support, so I don’t want to go off it completely.

Has anyone else been through this? If so, how long did it last? I am trying to tough it out, but it’s really hard to know when I should just request to back to the lower dose. I am just afraid my PCP will take me off it altogether if I say I am having any issues.

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Is this normal or hypomania?

For the first time ever, I went to see a psychiatrist for suspected ADHD/mild depression. They prescribed modafinil and Wellbutrin (75 mg). After day 12, I had trouble falling asleep and got less sleep every day until day 17, when I only slept for two hours (I had stopped taking modafinil for a few days so whatever it was, was not Modafinil). However, I didn't feel sleep deprived and had more energy and a better mood than before I started taking the medication. I didn't feel like I needed sleep at all. I was frightened, so I stopped taking them. I slept fine the night of next day. I went to the psychiatrist again, and now I'm on a fluoxetine and Vyvanse combo. It's day 8.

I am concerned about whether I am susceptible to mania/hypomania.

I also experience some symptoms when I take 200 mg caffeine capsules. This doesn't always happen, but I would suddenly feel very euphoric. My mood would jump from fatigue and depression to extreme euphoria, and I would find everything around me so interesting. Sometimes I would laugh uncontrollably. Once, I remember laughing in the shower, sitting down and laughing again at things in my head. Sometimes I also talk too fast and have to slow down when I take them. But I always experience extreme euphoria.

Can we just brush both off as 'just side effects', or is it concerning? Since fluoxetine is an antidepressant, I want to know if I should keep an eye out for similar symptoms.

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u/NewFirefighter2965 — 1 day ago
▲ 12 r/Wellbutrin_Bupropion+1 crossposts

Medication for ADHD and anxiety?

A little over a year ago, my psychiatrist prescribed Wellbutrin for my ADHD and anxiety. Although it provided a little relief at first, I notice that this has now diminished. I am really struggling with what might work for me; therapy alone helps too little, and I certainly think medication is something that could help. I think Wellbutrin alone is too activating. I don't suffer from very severe (physical) anxiety and function fine in daily life. I just worry a lot; my thoughts race very fast, and I find it difficult to put a stop to it. I ruminate all day about how im feeling, I analyse every little thought, i am very conscious about how I feel, and I always want to find an explenation to everything. I was wondering if there are other people with the combination of anxiety and ADHD, and what has helped you (with medication or in general).

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u/red-emenm — 2 days ago

Is loss of appetite common on this medication?

I have a new psychiatrist that doesn’t really listen to my concerns. I was originally on lexapro for depression & anxiety and got off of it due to sexual side effects so have been trying various medications to see what works. I was just prescribed bupropion but am nervous because everything I read says appetite suppression is a common side effect.

I told my psychiatrist I don’t want anything that suppresses appetite because I struggle with gaining weight and have worked hard to get my weight where it is now and don’t want to lose all that work. Is this medication likely to do this, and should I ask for something else? Hope someone can help out because am really concerned about this :(

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u/HonestLemon25 — 3 days ago

Should I not be doing this??

I take my pills (300ml x bupropion) with an energy drink (specifically a bubblr which is liek 69 caffeine) is this bad? it makes it go down easier. I also don’t do it at the same time everyday is that bad too

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u/LowCheesecake691 — 2 days ago
▲ 2 r/Wellbutrin_Bupropion+1 crossposts

Kicks in 12 hours after dose

I’ve been on Wellbutrin 150 XL for 5 months..
I take it right when I wake up 7:30ish and I don’t feel a bust of energy until 11-12 hours after.. has this happened to anyone? Any solutions? Thanks

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u/cryptomomtolaith — 2 days ago