In my country the options are basically:

bupropion XL (150 mg)

or

low dose amisulpride (50 mg)

which is worth trying first in your opinion? Are they even worth the risks/side effects?

Symptoms: apathy, anticipatory anhedonia, amotivation

no sadness or anxiety

So I was on 150 mg Wellbutrin for like three months and it wasn’t doing so much for me and I was still having bad anxiety from it. So me and my GP decided to add 10 mg Prozac on top of it. Big mistake. I got the worst panic attack ever yesterday and today. I swear I felt really overstimulated in a bad way. Almost like the feeling of being overcaffeinated. It was horrible. I was so scared something bad was going to happen. I haven’t had any caffeine at all. I removed all caffeine completely.

But today it was horrible. Massively overstimulated when taking them together. But I highly suspect it’s the Prozac because I wasn’t feeling this overly stimulated on Wellbutrin 150 mg all alone. I got side effects like hot flashes, burning sensations, heart palpitations, headaches, increased sweating, muscle stiffness, diarrhea and sleep disturbances. And I just woke up with the feeling of dread. Then I took my pills and immediately got a really bad panic attack and just felt overstimulated and overexcited in a really bad way. I went to the psychiatric ER immediately and they did some tests and then I talked to a nurse and she said that these side effects are probably the startup of Prozac and she told me to contact my GP as soon as possible and tell them about this. She told me if it gets worse and I can’t get in contact with my GP, they told me I can come back again.

I swear I just want to quit this shit. Prozac made me teen times worse. I was so much better off taking Wellbutrin all alone. Prozac made me so much worse I can’t describe it. 300 mg Wellbutrin was the only thing ever helping my depression but of course I couldn’t tolerate it anymore because it overstimulated me in various ways. Nothing else helped me. I’m devastated and I’m highly disappointed. Prozac worked for my anxiety in the past. But now I had a bad reaction to it. I don’t know what to do anymore. No antidepressants work for me I always have bad reactions to them.

Im mot talking about anticipation or avolition.With substance blockage psychedelics and MAOIs dont work on consummatory aspects, even if they may still help anticipatory. Mood stabilizers dont bring back actual pleasure.

By consummatory I mean the actual buzz in the head, and feeling passive pleasure of existence.
I am in an agitated state daily due to the anhedonia. The only thing that kinda helps is benzos but every day they are risky. And they only help take edge off

This constellation of symptoms can happen in severe PSSD, PFS, and post viral syndromes. Where th

In many cases the nervous system is so extremely dysregulated that substances further dysregulate it. Brain retraining also isnt possible due to the anhedonia itself.

What helps the goddamn blockage? Who had it and got out of it?

Ketamine does not work for me.

I was on 300 mg Wellbutrin for several years for my depression. It worked tremendously for my energy, motivation, cognition and brain fog and overall functioning and was the only thing ever helping my depression. But unfortunately in the end I couldn’t tolerate it anymore because it started to cause horrible anxiety and insomnia that started to interfere with my life in many ways. It also started to give me weird side effects I never used to get from it before and it just started to make me feel extremely overcaffeinated, which again never experienced that from it before. And once these side effects escalated I decided to drop back the dose to 150 mg.

Now I’ve been on 150 mg for more than three months now and I’ve already noticing my depression has worsened significantly and the racing thoughts and suicidal thoughts have come back all over again. I lack energy and motivation to do things. I’ve lost interest in things that I liked before. And I have lost almost all of my cognition that I had at 300 mg and the brain fog has started to come back. And I overall feel just so much worse emotionally and mentally than I did several months back when I was on 300 mg.

Now I did have an appointment with my GP recently and I told her all about this and she was like at first suggesting to go back to 300 mg all over again all by itself and then we would reassess in a few weeks again. But then I told her the reason I backed off the dose from 300 mg to 150 mg in the first place is because it started to overstimulate me and it caused horrible anxiety and insomnia. I told her it wasn’t because it wasn’t working anymore. I just couldn’t tolerate it anymore. I told her if I go back to 300 mg I might still need a med to remove the anxiety and insomnia.

And after that she was like we are putting Prozac back. I told her that I used to take 300 mg Wellbutrin and 20 mg Prozac for two years and that I experienced none of the insomnia or any of these side effects when I took it with Prozac. I told her that I think my body overall tolerated Wellbutrin better alongside Prozac. So that’s why her next suggestion was to put Prozac back. But then she said I only allow you to keep 150 mg Wellbutrin and then add 10 mg Prozac and then we reassess in a few weeks. Because when she searched on her computer she said combining Wellbutrin and Prozac can cause serotonin syndrome and then I told her I took them for literally two years with no issues at all. And when she said I can only have 150 mg Wellbutrin and 10 mg Prozac, I asked her can I never go back to 300 mg Wellbutrin and 20 mg Prozac again? And she just rolled her eyes and was like not now, It will be too much meds all at once. And I told her I completely understand that.

I mean I understand why she is being cautious and wanting to be more careful while introducing something else. But what if the next time I come back to her again and I tell her like it’s not working for me and I really want to return to the combination I used to take before, eventually if I can tolerate it. What if she turns me down and says I won’t prescribe this combination? I mean what do I do then? Because I’m 💯 certain the next time I ask for it, I know she will say no based on what she told me now. And if so do you think I should just get a second opinion? I know this whole text got way too long but I had to explain everything.

I have severe depression with chronic psychological pain. I took one 25 mg pill of fluvoxamine 3 months ago and it immediately made my psych ache significantly worse and it has stayed worse. Has anyone else had the experience of an SSRI making them worse permanently? Anyone have any ideas of drugs that could do the opposite of what fluvoxamine did?

Common signs of antidepressant injury include:

• Persistent sexual dysfunction (reduced or numb genital sensation, erectile problems, complete lack of desire for sex)
• Anhedonia (inability to feel pleasure or enjoyment in life), depersonalization (feeling detached from yourself or reality)
• Cognitive impairment (brain fog, memory problems, blankness, difficulty concentrating or holding a train of thought)
• Worsening depression, severe anxiety, panic
• Akathisia (extreme inner restlessness, agitation, terror, and often overwhelming urge to move or escape oneself)
• Balance issues such as dizziness, vertigo, lightheadedness, tremors, and gait instability

Evidence of lasting harm:

A 2025 medical study of 43 young men with persistent sexual problems after antidepressants found 92% had reduced genital sensation, 89% showed objective abnormalities on sensory nerve testing, and ultrasound revealed changes in penile erectile tissue — even though their hormone levels were completely normal. These problems continued long after stopping the drug. (Goldstein et al., The Journal of Sexual Medicine, 2025) 

Significant under-recognition exists because many patients are unaware their persistent symptoms are linked to prior antidepressant use, compounded by a lack of public education and healthcare provider awareness. (Healy & Mangin, Epidemiology and Psychiatric Sciences, 2024)

A 2024 large survey of over 1,100 people experiencing antidepressant withdrawal found very high rates of ongoing symptoms such as brain fog (93%), memory problems (88%), emotional numbing, and depersonalization (77%), with many effects lasting months or years. (Moncrieff et al., Journal of Affective Disorders Reports, 2024)

https://antidepressantinjury.com/

So I had a really stressful year in college filled with emotional abuse, academic overload, multiple viruses and burnout. When I finally returned home to rest I completely crashed. One night, a few nights after I got home, I was sitting around when randomly I started to feel this intense sensation of dread/dysphoria wash over me. It was like this deep pit of horribleness in my stomach, this feeling that something is horribly wrong. It was so intense my whole body was trembling. It felt like it would never end. And it didn’t. At the beginning it was more episodic but after a few weeks it kinda just faded into the background of my existence. For the last 2 years I have been living with this feeling all day every day. It doesn’t fluctuate much, it’s completely environmentally unresponsive, and it seems completely devoid of any content or meaning. It makes every moment feels unbearable and I genuinely am not sure how much longer I can handle it.

The symptom is accompanied by anhedonia, fatigue and upper body tension, all chronic and just as unresponsive to circumstances. To be clear, the feeling is distinct from anxiety because it does not involve worrying thoughts, racing heart or hyper vigilance. It’s more like unrelenting psychological pain. At this point in order to save my life I need to start trying treatments but I have no idea where to start. Has anyone ever seen a symptom like this before? Any suggestions of what treatments might actually help it? Any advice at all would be so apreciated.