▲ 2 r/MAOIs

Can the effect of MAOIs be replicated using combination of non-MAOI medications?

Since, MAOIs carry many risks and most doctors are not experienced enough to prescribe those, is it possible to create close enough effectiveness of MAOIs by combining multiple newer antidepressants and TCAs?

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u/KingMakerMan — 21 hours ago

Can the effect of MAOIs be replicated using combination of non-MAOI medications?

Since, MAOIs carry many risks and most doctors are not experienced enough to prescribe those, is it possible to create close enough effectiveness of MAOIs by combining multiple newer antidepressants and TCAs?

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u/KingMakerMan — 1 day ago

Which medications worked for you if you had depression with atypical features?

If you suffer from.major depression with atypical features, which medication worked for you?

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u/KingMakerMan — 2 days ago
▲ 6 r/depressionregimens+1 crossposts

Which medications worked for you if you had depression with atypical features?

Atypical depression is a subtype of major depressive disorder different from melancholic depression. The typical features (along with core features of MDD): mood reactivity, weight gain, increased appetite, laden paralysis (feeling heavy in arms and legs), and sensitivity to interpersonal rejection and criticism, sometimes also anxiety.

I have heard about studies that say MAOIs work best in this subtype. But the studies are mixed and inconclusive as there is conflicting evidence. The other day I saw someone on the zoloft sub, where sertraline worked very well for their atypical depression, which is a SSRI.

Many clinicians online say that the subtypes don't have much implication on treatment of MDD.

If you had atypical features (even if not officially subtyped diagnostically), which meds worked for you?

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u/KingMakerMan — 2 days ago

Do the DSM subtypes of Major Depressive Disorder (atypical, melancholic, anxious features, etc) have any implication of how psychiatrists treat patient?

Are treatment options different for different subtypes of major depressive disorder? Apart from psychosis, what about the specifiers atypical, anxious distress, melancholic?

Or is MDD diagnosis treated as a whole and drugs are trialled following the clinician's algorithm??

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u/KingMakerMan — 2 days ago

How can I stop correcting others in conversations and be someone who people can share their thoughts with without fear of judgement?

I recently realised after a series of incidents that I always tend to correct others in conversations. So, even closed ones have stopped sharing or opening up with me. They have formed the idea (and they are right) that I will always try to pin on them my version of correctness and not consider their option.

Is this narcissism? Or something else?

I don't want to continue like this. I want to get better as a person. I want to become a better friend, a better partner, a better safe space. I don't know why I do this overcorrecting others. How do I change that? How can I learn to be better? And where can I learn that? Books, articles, videos?

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u/KingMakerMan — 3 days ago

Where can I read about how major depressive disorder affects people in detail?

Depression (MDD) is a heterogenous disorder. But, I want to learn more about it's accurate description. How do patients present with this condition to the psychiatrist? How are different sectors of their lives affected? How do they recover? I have read throgh DSM's section on MDD. But it feels not deep enough.

I can download articles and books from my uni library.

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u/KingMakerMan — 4 days ago

How was life before and how did it change after finding the right regimen to treat your major depressive disorder?

Which medication changed your life for the better?

Also, how did it change? What were the changes that made you realise you were coming out of the hole? Were there symptoms that you didn't realise you had while you were depressed, only to realise once they got obliterated??

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u/KingMakerMan — 4 days ago

Bracing is the most helpful cue for a beginner in calisthenics than cues like pelvic tilts and all.

I may sound a bit rude. But the obsession with squeezing the glutes to go into posterior pelvic tilt is something that needs to be talked about. It is often over-emphasized in movements such as pushups, rows, etc.

What should be the number one priority is bracing the core like a belt and learning that. Many experts miss this cue during demonstration because their body naturally does this during resistance movements.

I learned it the hard way. As a beginner I just kept on squeezing the glutes until it started causing irritation in my upper glute region. Then I started with neutral pelvis and it went away. But I wasn't progressing with pushups or pullups for that matter. Then I started bracing properly in my movements and I started feeling muscles (although that is not important). More precisely I started feeling strong and started progressing with my workouts. My long desk job during my 20s and my inactivity and other life issues just ruined my core and deep core muscles. I couldn't sit without support. I had to rebuilt my core strength such that bracing becomes natural while lifting things or pushing things. I wasn't to me for a long long time.

I understand the appeal of PPT, but, for beginners I think learning to actively brace through movements should be top priority such that it becomes second nature and automatic with time.

Even I used to perform hollow holds without proper abdominal tension (bracing). I just focused on gluing my back to the floor. It didn't work

P.S: Infact, the calimove video for pushups in the FAQ doesn't talk about bracing at all. I understand because it is natural to the instructor since, they are advanced.

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u/KingMakerMan — 4 days ago

Which medications are good for someone who has already put on too much weight from their mental health condition?

Most antidepressants can increase weight as a side effect even though they can work beautifully for the original disorder that is being treated.

Depression itself can cause weight gain (weight loss for some). Those who were already overweight due to their mental health condition, which medicines worked for you and didn't affect weight that much??

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u/KingMakerMan — 10 days ago

What worked best for your anxious depression and turned your life around?

Anxiety is a comorbid condition for a vast majority of people suffering from major depression. Anxiety affects every part of life and build avoidance behaviors regarding everything including romantic relationships.

What med/therapy or combo worked best for your anxious depression, if you had it? And how did you realise that the treatment was working for you?

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u/KingMakerMan — 16 days ago

How does Generalised Anxiety Disorder affects long term relationships, commitment or intimacy?

GAD causes chronic worry and fear. It often exists alongside major depression.

​

But how does it affect relationships? Does it create insecure attachment styles? What is your experience?

​

I have fear of commitment and marriage. I have lost good relationships because of that. I don't want to lose more.

​

I got diagnosed as GAD, then changed to MDD. I am wondering whether I have cPTSD or GAD?

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Note: I have other fears too. Like social anxieties and all.

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u/KingMakerMan — 18 days ago

Anyone's treatment resistant depression/anxiety diagnosis here changed to CPTSD as the depression/anxiety started to lift a bit and you started connecting things?

Literally what the title says. My depression has started to lift and I realised that I have an avoidant attachment style which have ruined many things in my life. Also there are other issues that links to my childhood. Literally affecting all areas of my life.

In the next appt with my psych, I will bring this up. My diagnosis has once changed from GAD to MDD after I revealed more and understood myself more. I think I may have CPTSD and not just pure MDD.

Can that happen? If it happens, what worked best for CPTSD?

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u/KingMakerMan — 24 days ago

Can certain psychiatric medications affect thyroid function (TSH, Free T4 levels)?

I know Lithium can affect your thyroid function. I already have hypothyroidism. When I was taking sertraline my hypothyroidism worsened (TSH increased). I had to increase levothyroxine dose.

Now with Venlafaxine and Amoxapine combination I gained weight and got edema in legs. So tested out my thyroid function and TSH again came out elevated.

Is it because I am gaining weight on these medications? Or is it something else?

Has similar things happened with anyone else?

Edit: Also I am taking Topiramate (Topamax) for the associated weight gain with my psych meds. I started from 25mg and supposed to go upto 200mg. Can that be the cause of my abnormal lab values?

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u/KingMakerMan — 27 days ago
▲ 9 r/depressionregimens+1 crossposts

Can certain psychiatric medications affect thyroid function (TSH, Free T4 levels)?

I know Lithium can affect your thyroid function. I already have hypothyroidism. When I was taking sertraline my hypothyroidism worsened (TSH increased). I had to increase levothyroxine dose.

Now with Venlafaxine and Amoxapine combination I gained weight and got edema in legs. So tested out my thyroid function and TSH again came out elevated.

Is it because I am gaining weight on these medications? Or is it something else?

Has similar things happened with anyone else?

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u/KingMakerMan — 30 days ago

Can slowly coming out of major depression make you excited and scared at the same time?

I am getting treated for MDD. I am currently on Venlafaxine 225mg and Amoxapine 200mg a day in split doses. I have tried Sertraline, aripiprazole, Desvenlafaxine, Vilazodone, Buspirone, etc before. But this is the first time things are starting to get better.

I thought I had depression for the past 5 years. But now that I look back to my childhood and my familial issues, my relationship patterns and fears about commitment I realise that I may have been suffering from it since childhood or adolescence.

But the thing is, emotions were repressed for so long, I have slowly started feeling feelings again and the change is scaring me as well as making me excited at the same time. I am in an ambivalent position. Can this happen?

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u/KingMakerMan — 2 months ago

Can slowly coming out of major depression make you excited and scared at the same time?

I am getting treated for MDD. I am currently on Venlafaxine 225mg and Amoxapine 200mg a day in split doses. I have tried Sertraline, aripiprazole, Desvenlafaxine, Vilazodone, Buspirone, etc before. But this is the first time things are starting to get better.

I thought I had depression for the past 5 years. But now that I look back to my childhood and my familial issues, my relationship patterns and fears about commitment I realise that I may have been suffering from it since childhood or adolescence.

But the thing is, emotions were repressed for so long, I have slowly started feeling feelings again and the change is scaring me as well as making me excited at the same time. I am in an ambivalent position. Can this happen?

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u/KingMakerMan — 2 months ago
▲ 7 r/depressionregimens+1 crossposts

Has anyone tried a bunch of meds from different classes (SSRIs, SNRIs, TCAs, stimulants,etc) only later to find a 1st line med that actually worked for your depression?

Generally docs follow some sort of trial and error method (algorithm) to help find the right med for you. That doesn't mean that you have to try all SSRIs first and only then you can move onto a different class. Here doc experience comes to play.

But has it happened with anyone that after trying a few meds from different classes you come back to, say one SSRI you didn't trial before and it worked? Is it possible?

Because it is common wisdom that although all SSRIs, SNRIs or TCAs are classified like that not all medicines under one class are equal. Even it varies person to person.

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u/KingMakerMan — 2 months ago
▲ 10 r/depressionregimens+2 crossposts

What were your main symptoms (real life manifestations) of anhedonia and what cured it?

Anhedonia is one of the core symptoms of major depression, as we know. For you, if you remember, life with anhedonia and life without anhedonia, what were the main things that affected your life? When textbooks say lack of interest what does it mean? Can it be lack of interest in intimacy, relationships, marriage? Or is it just lack of interest in daily life activities?

I have MDD with anhedonia. I have lack of taste in foods, lack of interest in anything related to relationships, social activities, lack of joy in general.

I currently on Venlafaxine 225mg, Amoxapine 200mg, Trazodone 50mg and Prazosin 2.5mg. Hoping to find a medicine combo that brings my life back to normal.

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u/KingMakerMan — 2 months ago