u/KingMakerMan

I am getting treated for MDD. I am currently on Venlafaxine 225mg and Amoxapine 200mg a day in split doses. I have tried Sertraline, aripiprazole, Desvenlafaxine, Vilazodone, Buspirone, etc before. But this is the first time things are starting to get better.

I thought I had depression for the past 5 years. But now that I look back to my childhood and my familial issues, my relationship patterns and fears about commitment I realise that I may have been suffering from it since childhood or adolescence.

But the thing is, emotions were repressed for so long, I have slowly started feeling feelings again and the change is scaring me as well as making me excited at the same time. I am in an ambivalent position. Can this happen?

I am getting treated for MDD. I am currently on Venlafaxine 225mg and Amoxapine 200mg a day in split doses. I have tried Sertraline, aripiprazole, Desvenlafaxine, Vilazodone, Buspirone, etc before. But this is the first time things are starting to get better.

I thought I had depression for the past 5 years. But now that I look back to my childhood and my familial issues, my relationship patterns and fears about commitment I realise that I may have been suffering from it since childhood or adolescence.

But the thing is, emotions were repressed for so long, I have slowly started feeling feelings again and the change is scaring me as well as making me excited at the same time. I am in an ambivalent position. Can this happen?

Generally docs follow some sort of trial and error method (algorithm) to help find the right med for you. That doesn't mean that you have to try all SSRIs first and only then you can move onto a different class. Here doc experience comes to play.

But has it happened with anyone that after trying a few meds from different classes you come back to, say one SSRI you didn't trial before and it worked? Is it possible?

Because it is common wisdom that although all SSRIs, SNRIs or TCAs are classified like that not all medicines under one class are equal. Even it varies person to person.

Anhedonia is one of the core symptoms of major depression, as we know. For you, if you remember, life with anhedonia and life without anhedonia, what were the main things that affected your life? When textbooks say lack of interest what does it mean? Can it be lack of interest in intimacy, relationships, marriage? Or is it just lack of interest in daily life activities?

I have MDD with anhedonia. I have lack of taste in foods, lack of interest in anything related to relationships, social activities, lack of joy in general.

I currently on Venlafaxine 225mg, Amoxapine 200mg, Trazodone 50mg and Prazosin 2.5mg. Hoping to find a medicine combo that brings my life back to normal.