Since, MAOIs carry many risks and most doctors are not experienced enough to prescribe those, is it possible to create close enough effectiveness of MAOIs by combining multiple newer antidepressants and TCAs?
What's the procedure? I've been on 20mg for about 5 days now I think
So, I met with a new psychiatrist today. Initially, they were all for prescribing me an MAOI (since I've tried so many other meds).
But as the meeting went on, I described how significant my trauma was/is. The conclusion that they/we came to (at least, in the moment) was that my depression/anixety were/are a direct result of my trauma/PTSD.
I'm reflecting on the meeting now, and I'm asking myself, "does it really matter why I'm depressed/anxious?"
I mean, I know this means I'll need trauma therapy (which I'm getting), but it doesn't mean meds won't help, right? And SSRI's have made me feel flat while SNRI's made me anxious (I'm sensitive to norepinephrine).
My eye was/is on Nardil (Phenelzine). My psych thinks I'd do better on Propranolol and psychotherapy.
Idk what to think. I have depression (atypical), anxiety, AuDHD, OCD, Tourettes, PTSD, and trichotillomania.
Any advice/suggestions?
Thank you 🙏🏻
I (20F) have spent a good portion of my life struggling with MDD and have tried more than 15 medications. Currently, I am doing ECT, but am thinking of trying an MAOI as it is one of the only drug classes that I haven’t tried yet. I know that the dietary restrictions can be a lot—and this is why it hasn’t been prescribed to me before—but I’m running out of options… as a vegetarian, I would be completely okay without meats and without cheese, even, but soy and fermented foods are very common in the diet. Does anyone have any suggestions for filling food ideas that are both vegetarian and fit within the guidelines of an MAOI’s low-tyramine diet? Any advice would be super appreciated as this is something that I need to make work
I need a maoi supporter doctor that evaluates via video chat in Europe
I'm from Italy. The only maoi avaible here Is selegiline (jumex) so I need a receipt specifically for that
I have never been a person who is a push over/doormat and have always had a bit of anger issues but I have noticed that on 45mg of Nardil I get even angrier
Is this normal or should I be concerned?
Thanks
I've been taking Nardil for quite a while now. I started in February at 15 mg and slowly titrated up to 60 mg. I've now been on 60 mg for a little over two months.
So far, I've experienced **zero therapeutic benefit**. No change in my thought patterns, no reduction in social anxiety, and no improvement in self-confidence or overall mood, actually many problems and sides only.
E.g:
* Extreme gas (constant burping and flatulence) * Urinary hesitation/problems urinating * Constipation * Very low libido * Social anxiety sometimes actually feels worse * An occasional light "drunk" feeling
Though actually when I first increased from 45 mg to 60 mg, I *thought* I noticed some minimal (positive) changes. Looking back, though, I may have increased the dose too quickly, which forced me to go back down to 45 mg for a while. This time I titrated much more slowly back up to 60 mg, but after more than 8 weeks I still haven't noticed any benefit.
At this point, I'm wondering whether it's worth increasing to 75 mg—or even the maximum of 90 mg—or whether I should accept that Nardil simply isn't going to work for me and start tapering off?
A thing holding me back going even higher is especially all the withdrawal horror stories I've read. Part of me worries that if I go all the way up to 90 mg, it'll only make it harder to come off later.
Has anyone here had **little or no response at 45–60 mg for an extended period**, but then experienced a meaningful improvement only after increasing to **75 or even 90 mg**? I'd really appreciate hearing about your experiences.
Made a lot of posts on here recently cause I got a lot of questions so I appreciate everyone’s who’s given feedback/advice.
Feeling pretty woozy and out of it today. Haven’t slept well the past couple nights.
Taken my bp a couple times recently and it’s been like 140-150. Heart rate is like 100. Worked out kinda hard earlier today. Keep feeling on the edge of passing out.
Recently bumped the nardil dosage up to 60mg, been on it for a little over a month. Also taking .25mg pramipexole.
29 y/o male, theoretically healthy otherwise.
Anyone know what’s up. I feel off and I’m anxious about it.
Thanks
Once the Nardil kicks in does it feel like Pregabalin? E.g Extreme confidence, extroverted, motivated etc..
Can drinking socially most weekends stop
Nardil’s effects on anxiety? GAD/Social anxiety
Hey people,
Been on it for a month and a week. Started at 15mg. Bumped up to 60mg a couple days ago. First couple nights at 60 I slept good. Last couple nights I really haven’t. It’s really a bummer, not sleeping, cause it stresses your body out and you can’t think. Not sustainable.
For reference I’ve also taking pramipexole at .25mg / day the last couple weeks (was causing insomnia till I switched to mornings) and to sleep I’ve been taking 20mg melatonin an 25mg hydroxyzine. That was working till recently.
I get bad reactions from trazadone and seroquel, and I’d prefer not to take ambien again because, well, ambien.
Anyone found anything that works?
Thanks
I took Nardil for about 3 months with the highest I ever got up to was 45mg for maybe 2-3 days. Now I am down to 7.5mg in the am. I was given by my psychiatrist Lamictal 25mg to take during the washout period. He said to take Nardil and Lamictal together for 4 days and stop the nardil completely until my washout period is over. Any thoughts or suggestions would help!
Thanks in advance
Hi everyone. I’m likely going to start taking Nardil soon, as my psychiatrist is willing to give it a try (though there is some red tape involved in importing it as a foreign medication). I suffer from quite severe chronic anxiety and a form of dysthymia accompanied by apathy. I’ve also been diagnosed with ADHD, though I’m not sure if my cognitive dysfunction stems from the ADHD or is more a result of the severe anxiety.
In any case, I have a couple of questions about Nardil. The first is whether fatigue is a constant side effect or if it only affects some people. I have a demanding job and two young children. I think Nardil could really help me, as I struggle a lot at work, and with my kids, I’m even afraid to go to the park or the pool; however, I’m worried about being so tired that I wouldn't be able to do those things.
Another concern—which I haven't even discussed with my psychiatrist yet—is the issue of methylphenidate. I currently take a high dose (80 mg/day of a modified-release formulation, split into two doses), and it helps me a great deal with cognitive function. Although, theoretically, the two can be combined, I’m not sure if I should lower the dosage before starting Nardil.
Of course, I’ll discuss this at my next appointment, but I’d appreciate it if anyone with experience in this area could share their insights.
Hello,
I did have some caffeine yesterday. I’ve only been a week on 40 and did a little drinking last week. Sometimes my blood pressure raises after the second dose but not to 165/110. Any thoughts?
Hey guys. So I’m still struggling with major depression disorder and my doctor is very open minded and familiarized with MAOI medications. He says that we can augment nortriptyline because he’s seeing success with that combination.
I’m just seeing if anyone has had any experience with adding in nortriptyline and if it’s helped with your depression while being on Nardil. Any advice given would be appreciated!
Thanks guys.
Hey everyone - posting this for reference in case anyone finds it helpful.
I restarted Nardil in March. I get my liver enzymes tested very regularly for blood work monitoring after I went through chemo last year. Here are my results and timeline on Nardil.
Note that I restarted Nardil and at the same time started supplementing vitamin B6 (P5P) at around 35-50 mg a day. I was under the impression this would help with muscle cramps.
December (on Wellbutrin) - ALT and AST were 20 and 22. Discontinued this in February.
March (1 week after starting Nardil) - ALT and AST both elevated >100
April - ALT and AST remain elevated over 100
May - AST dropped to normal range but ALT remained elevated at 102.
June - Discontinued B6 P5P for ~10 days and retested and ALT dropped to 63. This was 10 days after my blood test where it was elevated at 102.
I will continue to monitor but I've discontinued all B6 supplements for now. I did read a study where P5P increases hepatic load of hydrazines but I can't find it now. I would love if someone could share it here.
Hello,
I did have some caffeine yesterday. I’ve only been a week on 40 and did a little drinking last week. Sometimes my blood pressure raises after the second dose but not to 165/110. Any thoughts?
Has anyone taken selegine oral tablets or ensam patches and did they help with major depression, and if so, how long did they take to work? I have tried Zoloft, lexapro, Wellbutrin, Effexor, pristiq and now cymbalta and most medicines either don’t work for me or stop working. My dr seems to think this is a good option. Thanks in advance!
I haven’t taken parnate just yet, but I plan to soon. Before taking it, I already unfortunately experience a mild Insomia and I think it’s very likely going worsen the Insomnia I already experience (I’m a very light sleeper).
Does anyone know a safe sleeping aid to combat parnate’s Insomia side effects?
Hi I'm on 40, mgs. So tired during day - hard to keep eyes open. What can I take during the day that is not addictive? In recovery so can't take methylphenidate or amphetamines - modafanil etc
Thank you