u/Daniel-Plainview96

Made a lot of posts on here recently cause I got a lot of questions so I appreciate everyone’s who’s given feedback/advice.

Feeling pretty woozy and out of it today. Haven’t slept well the past couple nights.

Taken my bp a couple times recently and it’s been like 140-150. Heart rate is like 100. Worked out kinda hard earlier today. Keep feeling on the edge of passing out.

Recently bumped the nardil dosage up to 60mg, been on it for a little over a month. Also taking .25mg pramipexole.

29 y/o male, theoretically healthy otherwise.

Anyone know what’s up. I feel off and I’m anxious about it.

Thanks

Hey people,

Been on it for a month and a week. Started at 15mg. Bumped up to 60mg a couple days ago. First couple nights at 60 I slept good. Last couple nights I really haven’t. It’s really a bummer, not sleeping, cause it stresses your body out and you can’t think. Not sustainable.

For reference I’ve also taking pramipexole at .25mg / day the last couple weeks (was causing insomnia till I switched to mornings) and to sleep I’ve been taking 20mg melatonin an 25mg hydroxyzine. That was working till recently.

I get bad reactions from trazadone and seroquel, and I’d prefer not to take ambien again because, well, ambien.

Anyone found anything that works?

Thanks

Appreciate any input/advices!

I’ve been on most SSRIs/SNRIs over the years with little success. So far, **Parnate** has been the best antidepressant I’ve taken.

It worked well for about 6–7 months, which is longer than any antidepressant has ever worked for me. The downsides were insomnia and one teency weency hypertensive episode that landed me in the ER.

I’m now about a month into **Nardil**. I started at 15 mg and am currently at 45 mg. Hesitant to increase to 60 mg because it almost feels like both the antidepressant and anxiolytic effects have already faded, even though I was definitely noticing them at first.

Main draw for Nardil was the touted anxiolytic effects, but if what I’m experiencing now (intermittent anxiety, brain fog, heavy fatigue) is the supposed anti-anxiety, I’d probably prefer raw-dogging life med free. I’m already diagnosed chronic fatigue syndrome. Need something that gives me energy, not takes it away. Lately, on Nardil, sometimes I’m so brain dead I can’t even talk good.

I’d love to hear that Marplan is more energizing or at least doesn’t worsen fatigue and makes it easier to focus and function day to day.

I’ve heard **Marplan** has a milder side-effect profile, so I’m very interested in hearing from people who’ve actually taken it—especially if you’ve also been on Parnate and/or Nardil.

A few questions:

How did Marplan compare in terms of antidepressant effect?

How did it compare for anxiety?

Did it affect your energy, fatigue, motivation, or ability to focus differently than Parnate or Nardil?

What were the side effects like compared with Parnate or Nardil?

If you’ve taken all three, which ended up being the best fit for you, and why?

I’m seriously considering trying Marplan once it’s available again, so I’d really appreciate hearing about people’s real-world experiences.

Thanks 🙏

Appreciate any input/advices!

I’ve been on most SSRIs/SNRIs over the years with little success. So far, Parnate has been the best antidepressant I’ve taken.

It worked well for about 6–7 months, which is longer than any antidepressant has ever worked for me. The downsides were insomnia and one teency weency hypertensive episode that landed me in the ER.

I’m now about a month into Nardil. I started at 15 mg and am currently at 45 mg. Hesitant to increase to 60 mg because it almost feels like both the antidepressant and anxiolytic effects have already faded, even though I was definitely noticing them at first.

Main draw for Nardil was the touted anxiolytic effects, but if what I’m experiencing now (intermittent anxiety, brain fog, heavy fatigue) is the supposed anti-anxiety, I’d probably prefer raw-dogging life med free. I’m already diagnosed chronic fatigue syndrome. Need something that gives me energy, not takes it away. Lately, on Nardil, sometimes I’m so brain dead I can’t even talk good.

I’d love to hear that Marplan is more energizing or at least doesn’t worsen fatigue and makes it easier to focus and function day to day.

I’ve heard Marplan has a milder side-effect profile, so I’m very interested in hearing from people who’ve actually taken it—especially if you’ve also been on Parnate and/or Nardil.

A few questions:

How did Marplan compare in terms of antidepressant effect?

How did it compare for anxiety?

Did it affect your energy, fatigue, motivation, or ability to focus differently than Parnate or Nardil?

What were the side effects like compared with Parnate or Nardil?

If you’ve taken all three, which ended up being the best fit for you, and why?

I’m seriously considering trying Marplan once it’s available again, so I’d really appreciate hearing about people’s real-world experiences.

Thanks 🙏

Edit: I WASN’T getting any insomnia from the Nardil (autocorrect changed wasn’t to was, which was confusing)

First post here

Just started pramipexole at .125mg and then bumped up to .25mg after a few days. Been on it for about 5 days total.

Right away I can notice the positive effects. I’m a lot more confident and just locked in. Food tastes better. I’m feeling satisfaction/joy from things I usually would be completely numb to like a nice view. I’m feeling motivated to plan and hopeful for the future. Among other things, I have PTSD and because of this, basically constantly disassociated, so it’s making me feel a lot more “in the moment” rather than being aware of myself from the third person/being just zoned out like usual.

If these positive effects remain (or even get better) that would be such a huge win, but I notice I just haven’t heard that many long term success stories with it. Has anyone taken this long term and had it stay working? Did the side effects go away?

Next, the insomnia hasn’t been great. I did my last few doses either entirely or half at night, and felt like even though I was tired I couldn’t ever really sleep. I would just dose in the morning but there seems to be a few hours of not feeling great / feeling fatigued after the dose (but unable to nap successfully.)

For what it’s worth I’m taking this alongside the MAOI antidepressant, Nardil (Phenelzine) but I WASN’T (edit: autocorrect changed wasn’t to was) really getting any insomnia from the Nardil, at least nothing compared to this. I really want this to work because, if I could just get rid of this insomnia it seems like it would be perfect. Will this go away with time?

Thanks

Made a lot of posts lately. Sorry guys. Just tryna get more information about this weird drug—how to hopefully make it work for me.

Currently on 45mg / day. Bout 3 weeks. Started at 15, titrated up pretty quick after reading stuff in here.

Been trying to pin down exactly how to take my Mylan-Brand phenelzine (which is apparently the EXACT same pill as Greenstone AND Pfizer now after a merger or something 🤷‍♂️ ) and so far, after I take the pill(s) in the AM, I’ll get a few hours of energy/motivation… which slowly gives way to despair and brain-fog as the day goes on, such that, about 6 to 8 hours later, I’m headachey and anxious. I can’t think or speak, like I’m stupified or daft. Lots of “uhhhhs” and “unmmmms” and “sorry I forget what I was sayings.” Truly, during those times it’s like I’m a “few cards shy of a full deck” if ya catch my drift (retarded).

Then, finally, the anxiety slowly abates over the next few hours, but never completely. It’s gone the next day when I wake up, and then the process starts all over again as soon as I snarf down them little orange bitches. #Swag.

Has anyone experienced this sort of thing starting Nardil before? I’ve taken parnate and selegeline before and never had this weird yo-yo-ing of the mood. This morning I feel cool as a cucumber, but last night I was so anxious I didn’t even want to text people back.

The yo-yo-ing got better when I stopped cutting the pills to take half at a time. That was bad. Still it’s not great though.

I also started taking the pills on an empty stomach too in the hopes it won’t dissolve till it gets past the stomach and bypasses the liver to have a different, better effect or something. That’s helped a bit.

Any suggesties?

Thanks

Hello

I've been on this stuff for about 2 weeks. It's been a roller coaster. Just bumped from 15mg to 30mg. Was splitting the 15mg pill into chunks. Have been getting yo-yo-ing euphoria, dysphoria, and back to euphoria in the hours following dosing.

https://www.reddit.com/r/MAOIs/comments/1u39acr/mood_swings_starting_nardil_euphoria_to/ (Post I made about the weird mood swings)

It's recently come to my attention this could be because, by cutting the pill, its absorbing too quickly in the stomach and not enough is reaching the small intestine where, supposedly, it can bypass the liver, thus somehow affecting the amount of MAO-A vs MAO-B and the resulting neurotransmitter levels. Not sure how correct that is but I'm definitely just gonna take whole pills for a bit and see if that doesn't help.

However, I'm also just curious if the brand, Mylan, couldn't be somehow "not good." Does anyone know? Someone on here said the general consensus for Nardil Manufacturers goes something like this:

"Neon (UK, AUS) > Pfizer (US) > ERFA/Searchlight (Canada) > Greenstone (US)."

I don't see Mylan on there so I'm wondering where it stands. And Mylan aside, do we agree with the above assessment?

Also, when do we take our nardil? Empty stomach? Anyone tried both nardil and marplan and can speak to which is better?

Please give me answers folks! I want this to work!

Many thanks.

Hello community,

I’ve been on phenlzine about 2 weeks at 15mg. Been spacing my quarter (3.75 mg) dosages throughout the day to combat some weird mood fluctuations.

Before that I was taking amitriptyline for headaches, but it was also giving me a nice antidepressant / anxiolytic effects. (With a strange rebound anxiety towards the end of the day).

I stopped taking the amitriptyline before starting the phenelzine because Google said they were contraindicated, but after reading some stuff on Reddit it seems they’re really not, so I took the amitriptyline (12.5mg) before bed with ny last 3.75 nibble of phenelzine and, lo, I did not die of serotonin syndrome.

My question is, does anyone have any experience combining these two? Was it good? Bad? Synergistic? Catastrophic?

Also, my phenelzine appears to come from the brand Mylan pharmaceuticals. I understand there’s some pretty big differences in effectiveness between brands, is Mylan any good?

Also, I started taking a broad spectrum b vitamin with p5p as b6. I understand supplementing with b6 can be good because phenelzine uses up b6, binds with b6, and / or impedes the conversion of b6 to p5p. It’s a little confusing, because some sources say to not use the p5p form of b6 with phenelzine, while other sources say it’s superior.

Any insight helps!

Thanks! 🙏

OK so forgive my limited understanding but essentially, if you’ve heard the warrior gene, it describes a specific allele or predisposition or whatever on the X chromosome that dictates how much of the MAOA (monoamine oxidase A) is made and, in turn, influences neurotransmitter retake.

It’s my understanding that variations of this gene that code for less monoamine oxidase enzyme lead to naturally higher levels of neurotramsitters like, of course, dopamine and serotonin. The “warrior gene,” which refers to having a version of this gene that encodes for little (and possibly none) of this enzyme gets a bad rep in pop science because it’s been linked with antisocial traits in individuals with rough upbringings. What’s less commonly talked about is it’s also linked with highly successful and motivated people. CEOs and serial killers alike. Take a look at a Ted Bundy type, he was not too worried about his actions because he felt above everyone. Serotonin. He was also highly motivated/driven. Dopamine. Same could be said for highly successful people in society.

When we take MAOIs, as far as I can tell, we’re almost recreating the effect of a “warrior” gene by deactivating/inhibiting the enzyme that the “warrior” doesn’t have in the first place.

Well then wouldn’t you expect to see an increase in antisocial behavior when taking an MAOI? Not necessarily. It would make sense (and this is just me guessing) that the increase of neurotransmitters brought about by an MAOI in adulthood doesn’t automatically/necessarily come with a decrease of empathy because, theoretically our brains weren’t formed with the surplus of neurotransmitters that theoretically, at least partially, keep individuals who tend towards sociopathy/narcissism from ever developing empathy. Not sure if that made any sense.

That is ABSOLUTELY not to say an individual with the warrior gene won’t have empathy, and that an individual without it automatically will. Obviously way more genes are involved, as well as environmental factors, especially in early childhood.

All that said, if someone with the warrior gene takes an MAOI, wouldn’t it be far less effective because it’s basically redundant?

Thanks

Hi all,

Recently started Nardil at 15 mg for TRD. Having the weirdest and most unexplainable reaction and I could really use some insight if anyone has any.

So depending on when I take my dose, I'll experience pretty wild mood fluctuations within the first 3 to 6 hours. I've started breaking the 15 mg into two 3.75 mg doses early in the day and one 7.5mg dose before bed, but I still get the mood swings.

I've been taking it two weeks now and it varies day by day, but some days I'll take my morning nibble and I immediately feel like I'm on something in a not-good way, where I disassociate, my thinking slows, my depression becomes pronounced, and I find myself too anxious to function. Very odd. More often though the dose(s) is (are) followed by an hour or so of mild euphoria during which time I notice a sharp increase in libido. But THEN, only another hour or so later, I experience that pronounced dip into anxiety / disassociation / despair / fatigue... which THEN finally gives way to a chippy mellow feeling, not quite as euphoric, but somehow “sharper” then I’d feel during the initial euphoria…

These changes are night and day and seem to have mellowed out just a bit in the last two weeks, but not entirely. I started taking half before bed so that the mood swings would work themselves out while I was asleep and I would wake up mellow. I really can't do this largely-unpredictable yo-yo-ing, and, based on my understanding of how this drug works, I have no idea why it would be causing this.

I've taken parnate and selegeline before and never experienced this. I don't have mood swings naturally, and these mood swings are pronounced and seem entirely independent of external factors (like having received good or bad news for example).

If I could predict how I'd react and get the timing right, I could sort of schedule my day around it and plan accordingly, but as is, I can't. I wouldn't, for example, wanna be on an important work call and find myself unable to speak and in the pits of despair, only to find myself two hours later feeling cool as a cucumber and chipper.

One thing I've noticed is that, despite the overall unpredictability, as I've adjusted dosing schedule in the hopes of finding one that works, no matter what I typically have a period of negativity in the evening, which gives way to a period of content-ness in the few hours before bed. Beyond that, there's much more variability than consistency, and that's proving problematic.

Again, any insight really helps. Thank you.