Suddenly meds seem to not be working?
My 10yo daughter has been on 27mg methylphenidate plus guanfacine IR 0.5 mg at bedtime. She started stimulants at 7 after several years of intense emotion dysregulation that started to get dangerous in our home - we have two other kids. Aggression, paranoia, antagonism, provocation, etc. She’s done well for years now and things have been great. Occasionally increase in dosage to maximize benefit etc but we’ve never gone back to pre-meds level of functioning… until now. The last few weeks have been so painful. It’s the same as before but she’s a lot bigger and smarter now. We are working with our psych who we love and we just tried changing to guanfacine ER 1mg. It’s seemingly had zero effect on the dysregulation. Yesterday was a very scary day where I saw her reach and maintain for hours nearly psychotic levels of paranoia and anger. The doc is talking about increasing the dose since she’s grown a lot in the last year. Just wondering if anyone has experienced this seemingly sudden change in meds efficacy and if so what your experience was/what helped?