u/Crazy_Series_2719

If you are in the NYC area. May be worth a shot to enroll.

https://jcto.weill.cornell.edu/open\_clinical\_trials/an-open-label-single-center-investigator-initiated-phase-1b-trial-of-e-cel-uvec-cell-therapy-for-the-treatment-of-chronic-anal-fissure

Posted a week back, had a small re-tear after 3 good months, which CRS labeled it as acute fissure now. Have had the fissure for almost a year now. Reopened twice during that time.

Previous times it reopened l, I felt the pain but no blood, surprisingly during the whole time I had this, I never saw blood. Maybe there was some in the beginning and I didn’t notice,

After this latest re-tear had 4 days of small amount of blood. Next 4 days, no blood, no real pain. Now today a little more blood, even though BM was soft and small and some more pain. It’s definitely not the amount of pain there was in the beginning, but still noticeable. For people who have had blood. Is this normal to go on/off with days with blood then no blood? I feel that if there is blood, then obviously it isn’t healing.

I’m going to increase MiraLAX a little bit, because maybe BM is just a little harder and don’t see it, but it looks and feels soft when passing.

Was going good for a while, guess it’s too much to ask to go back to normal. Got a fissure from colonoscopy almost a year ago. Fissure has “healed” and reopened twice. Now this week will be a 3rd time. I really thought I was going to make it this time. It has been a solid 3 decent months of no real pain or issues.

I have been on a pretty strict diet and did something dumb and ate a funnel cake, which caused a loose BM. Next day after everything was normal, followed by a day of no BM, then a hard BM that caused bleeding. CRS confirmed yesterday small fissure at anal verge again, which she said should close again in a couple weeks with soft BMs.

The problem is, I am now stuck in a loop, and don’t know why. Last 3 days BMs have been harder and smaller, with blood still. I am mostly back on my diet, but it is harder to eat as my calories as anxiety and stress level are through the roof. I now have a constant fullness and urge to go, which are new symptoms from previous setbacks. I take Metamucil (5g fiber) in the morning and small dose of MiraLAX at night. Im usually 1700-2000 calories and 25-30g fiber. I’m upping my MiraLAX dose today to see if that will help. Anyone else been stuck in a similar situation and what can I do to break this cycle and get my BMs back to normal.