u/Crowhearted

I just switched from Wegovy to Zepbound, and I’m worried I’m making a mistake.

I had stalled for 2-3 months on 1mg semaglutide, and also could tell my inflammation and pain was returning, so I titrated up to 1.7mg for a month. Pain reduction is still my main goal. This restarted my weight loss + all the positive effects I had been experiencing, but also gave me even more GI symptoms and allodynia.

My doctor decided to switch me to Zepbound, and it has been ROUGH. I’ve sick since taking my first dose with nausea, stomach cramps/pain, and so much fatigue. I did have a pretty rough first three weeks titrating up to my latest Wegovy dose, but I don’t know if I felt this bad?

I was not told to do any kind of tapering, so I know I have both of the medications in my system right now. This is the first time I’ve felt like my appetite has been absolutely KOed and I’m completely food-averse. And on top of it all, I don’t think I’m going to see the scale move this week. 🫠

Do I just need to give it time? I was hoping my side effects would get better and I was not expecting a sucker punch of side effects all of a sudden.

After tolerating all my previous doses of Wegovy well enough for the last few months, I titrated up to 1.7mg a few weeks ago. It was definitely time to, but now I’m having relentless acid reflux, nausea, and stomach pain. I dealt with years of terrible, near-constant GERD/nausea/vomiting before and I am in no way wanting to revisit that time in my life.

My doctor debated either moving me back down to 1mg or switching to Zepbound. Since I feel great at this dose wrt inflammation and food noise, and less so at 1mg, he chose to try Zepbound first rather going back down in dose right away.

I’m nervous! I’ve been responding well to semaglutide overall until now (although weight loss is slowing even with the higher dose) and I’m so anxious that it’s all going to go haywire. Has anyone else switched? What was the process like?

I’m on semaglutide. I get occasional stomach pains/cramps, usually if I have something that doesn’t agree with me like alcohol or caffeine. (I also got them occasionally pre-GLP - thanks, IBS.)

I just recently went up to 1.7mg and woof, this one is rough all around. Stomach cramps are more frequent and more uncomfortable, although not severe. I can’t really ID a specific thing that is triggering them at this new dose.

Does anyone know what might help ease them a bit? I can deal with reflux with my PPI and nausea with Zofran, but I’m at a loss about the abdominal pain.