
When you realize, no matter who wins on Avarax and Demerium, all these dudes are dead
Either the Tyranids eat them, the TSons kill them or corrupt them to be killed by us...
...or the Inquisition shows up and executes the survivors because they've now literally seen things the Imperium doesn't want the greater public to know - Traitor Astartes, daemons, the very existence of "Chaos" - or because even coming in contact with the enemy might result in them being tainted (similar to Titus in SM1) but either way.
....buuuuut I'll also say, YMMV on this: while this is a known thing that the Inquisition does and one of the reasons the Space Wolves literally fought them and the Grey Knights after the First War for Armageddon, namely the "Months of Shame" afterwards, 40k has been known to go so out of the way to be grimdark that there's no way something can be taken seriously, like "every world in the Imperium is a fascist hellhole where everyone works 20 hour days" or the number of times an Inquisitor Exterminatus'es a planet, or "a million guardsmen die every minute of every hour of every day". If the Inquisition really did kill every single Guardsmen that fights against Chaos and wins, 1. who's left to fight Chaos 2. who's left to pass on their knowledge and expertise, and 3. that would strengthen at least one Chaos God, if not 2-3, which in turn leads to more daemonic incursions, stronger daemonic forces, and so on, and so on, and so on...so yeah.
Either way. Depends on how you look at it.