u/DecypherNexus

Feeling "Out of It" & Suboptimal: Imbalances In Estradiol (E2), Prolactin, SHBG, and Low Free T despite good Total T.

Feeling "Out of It" & Suboptimal: Imbalances In Estradiol (E2), Prolactin, SHBG, and Low Free T despite good Total T.

Hi everyone, I'm new. Im 32 and since more than a year I've been dealing with lack of energy, no motivation, lack of "drive," absent libido, and ED. Not even daily Cialis is helping at this point. I also go to the gym 3-4 days a week and do some cardio at the end.

I'm looking for advice on how to optimize this panel. To be honest, I feel like my existence is just 'ornamental' right now—I’m physically here, but I have no drive, no spark, and no 'manhood' left. It's devastating.

Questions

  1. The Free T Paradox: My Total T is 731, but my Free T is at the literal bottom of the range (15.10). Is lowering E2 and SHBG the only way to "unlock" my own testosterone?

  2. Prolactin at 21.0: Since I’m over the range, could this be the main reason Cialis is failing me? Should I jump straight to P-5-P or consider something stronger?

  3. Protocol Sanity Check: My doctor wants me on 3mg of Anastrozole/week (Monday, Wednesday, Friday). which sounds like a massive overkill and I'm afraid of crashing my E2.

I’m leaning towards 0.25mg twice a week instead.

- Does this sound like a more rational starting point for someone who isn't on TRT?

- Has anyone fixed their ED/Mood by lowering E2 and Prolactin with these numbers?

u/DecypherNexus — 11 days ago