The trailer for the new game has my incredibly hyped and I love all the fanart and memes that spawned from the announcement. But the online discourse around this game is terrible and I had to call it out.
Even if you don't really jive with modifier system, you should definitely turn on some modifiers as soon as you unlock them. There is a trophy that requires runs with modifiers turned on (I never noticed it).
I'm no big fan of making games I play easier, so if you're like me you should definitely turn on corruption enhancement. You barely notice it anyway and it doesn't make you OP or anything like that.
I always start my runs of the first region and was wondering why I haven't seen any Halcyons in a while. Every location has a set amount you can pick up, so definitely start focusing your runs on later regions once the drops dry up.