Disclaimer: Yes, the information is not singularly found out by me but compiled from different sources to really represent my personal view on the meta.
Ranking and advice of all activities:
S+-Tier
Helltide
Tree: Middle Path then Left
Double Helltide is favourable
Do Helltide if Forgotten Souls are scarce
Do not die with many cinders
S-Tier
Undercity
Tree: Left Path then it is a wash
Look at the quality of your keys
NEVER run Armament keys before mythic
Run Mythic Tribute of Armaments on T10
A+-Tier
NM Dungeon
Tree: no right answer here, depends on what you need
(Loot wise I prefer Conviction over Horadric altar)
You can amalgamate sigils to escalation dungeon
Ancestral escalation is very profitable
Obol reserve + Conviction does not work
A-Tier
Boss Lair
Tree: Middle Path (double boss portal!!) + Dog
Run Whisper Lair out of order if you have many keys or need certain uniques
Loot Table is out dated, Astaroth may be circumvented with Belial
C-Tier
Pits
Level Glyphs, rest is meh
Tree: Left for glyph upgrades
D-Tier
Horde
It is simply in a bad spot
Tree: Left path, maybe downgrade torment to improve chances
No tier
Whisper
Tree: Middle Path for spark chance