u/Dragonfruitygirl

Shorter intervals instead of increasing dose?

Has anyone here had better results with a lower tirzepatide dose taken at shorter intervals rather than increasing the weekly dose?

I’m currently on my 6th dose of 5 mg, so technically I could move up to 7.5 mg now. However, I’d really prefer to stay on the lowest effective dose possible.

My issue is that 5 mg works very strongly for the first few days, sometimes to the point where I can barely eat at all for a day or two, but by around day 5–7 I notice the appetite suppression and food noise control wearing off quite a lot.
That’s why I’m wondering whether anyone has experience with staying at 5 mg but shortening the interval instead, for example every 5 or 6 days.

My thinking is that 5 mg every 5 days averages out to roughly 7 mg per 7 days, so the overall exposure increases, but potentially with a flatter peak/trough pattern than taking 7.5 mg all at once every 7 days.

What I’m hoping to avoid is having two days where I can barely eat at all, followed by one or two days at the end of the week where the effect drops off significantly. I’d much rather have a more stable level of appetite suppression throughout the week.

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u/Dragonfruitygirl — 2 days ago