six weeks in, 2mg weekly, injecting Sunday nights. mornings are electrolytes, magnesium glycinate, b complex, vitamin d with k2. protein shake within an hour of waking up. trying to hit around 140g protein daily. gym three times a week, mostly resistance with some cardio. down 11 pounds so far, hunger is manageable, side effects have been pretty mild.
where are the gaps, what am I missing, what would you change
I just do not know if that would actually be enough to fight the hunger coming back. Some data shows that people tend to regain weight incredibly fast once they stop these medications compared to normal dieting. That is exactly what makes me paranoid enough to think about these scenarios.
So just as CagriSema was gearing up for launch, company reports now seem to be highlighting zenagamtide, its next-generation candidate that also targets both GLP-1 and amylin but is combined in a single molecule. This has led to some speculation that CagriSema might be taking a backseat before it even hits the market.
The company insists that "no change in plan" for the CagriSema launch, and an FDA decision is still anticipated by late 2026. The combo has already shown clinically meaningful weight loss of around 23% in trials. But it's worth watching to see which of these amylin combos actually makes it to patients first.
I am really prone to hair loss and I am trying to figure out if it is actually possible to keep your hair while running a cycle. I know that blasting high doses of testosterone or taking DHT derivatives like masteron and primobolan will absolutely destroy your hairline. Even stuff like trenbolone and halotestin seem like a guaranteed way to go bald. But I keep reading that if you stick to milder compounds like nandrolone, anavar, or equipoise, you might be okay. Some people claim you can even run bigger cycles with a decent amount of test if you use things like finasteride to block the conversion and slap on some RU58841 to protect the follicles. Is it really as simple as picking hair safe compounds and running the right protective topicals, or are you just fighting a losing battle if you already have the genetics for male pattern baldness? I just want to know if anyone prone to hair loss has actually managed to blast gear and keep their hair long term.
kept seeing this question a lot so figured i’d just throw my thoughts in because i was wondering the same thing not long ago
i think people get confused because “working” isn’t just one thing with this stuff
there’s appetite suppression, and then there’s actual fat loss, and they don’t really show up at the same time for everyone
1. appetite changes come first.
For me and a lot of others it was pretty quick, like within the first 1–2 weeks you start noticing food is just less of a thing
you get full faster, cravings calm down a bit, and you’re not thinking about food 24/7
that said at lower doses it’s usually pretty subtle at first. nothing crazy, just noticeable if you pay attention
scale might move a little in the first few weeks but a lot of that is just water weight or eating less junk
the more noticeable drop usually doesn’t really kick in until a bit later once the dose is up and steady
that’s when it starts compounding and you actually see consistent week-to-week changes instead of random fluctuations
mirror changes lag behind the scale pretty hard. Clothes fitting better, face leaning out, that kind of stuff usually shows up after a month or two for most people and im saying MOST because it vary’s. The big results people talk about are more like months in, not weeks
Tl;dr
If you’re too lazy to read then here’s what to expect
> week 1–2: appetite changes
> weeks 2–4: small scale movement (sometimes)
> month 2–3: things start picking up
> month 3+: more noticeable fat loss
> 5+ months: where the big changes really show up
basically if you’re early on and feel like nothing’s happening yet, that’s pretty normal
would be curious to hear other people’s timelines too because it seems results vary a lot
I lost insurance coverage for Zepbound (employer dropped weight loss meds). I'm now paying cash. I compared three discount options for a 1-month supply of 10mg.
Here's what I found (prices from my local CVS):
GoodRx:
Claimed price: $1,050
Actual price after coupon: $1,020
No restrictions, easy to use
SingleCare:
Claimed price: $1,100
Actual price after coupon: $1,075
Slightly worse than GoodRx
Zepbound savings card (cash pay version):
Claimed price: 650 (800 list - $150 coupon)
Actual price: $650 (same)
Restriction: Only 7 fills per year
The savings card was almost $400 cheaper than GoodRx. I didn't expect that. I assumed the coupon was only for insured patients. But the 7-fill limit means I need a plan for months 8-12. I'm considering switching to compounded for those months.
I know there have been endless complaints about personal stories here recently but I just feel like sharing it here since I’ve been lurking on this sub for quite a while now. So I've lost 65lbs on Mounjaro. My body has changed gradually. But my face? I caught my reflection in a store window yesterday and literally did a double take.
My cheeks are less round. My jawline is visible. My neck looks longer. I look like a younger, thinner version of myself. But also like a stranger. My husband says I look the same, just "less puffy." But I don't feel the same. I feel like I'm wearing a different face.
I finally hit my goal weight after a long cut on Retatrutide. I feel amazing about the results, but now I really need to figure out an exit strategy. I absolutely refuse to be pinning this stuff for the rest of my life.
For anyone who has completely come off, how did you actually do it? Did you slowly taper your dose down over a few months, or did you just drop it cold turkey and strictly track your macros? I'm a 38f and I'm terrified of that massive rebound hunger everyone always warns about. I just want to maintain where I'm at without relying on it forever. What is the best way to handle stopping?
I am currently down 65lbs on grey tirz at 10mg and my BMI went from 38 to 24. The source I’m currently using as of now is pretty expensive and unless I find another then I’d just give up on this whole thing. But I also can't face regaining everything I worked for
I’ve been looking at a lot of progress photos lately, and while the weight loss is impressive, the GLP face is starting to look a bit scary. It seems like the second someone hits a high dose and the weight starts falling off, their face just completely collapses. I’m seeing people in their 30s who suddenly have deep nasolabial folds and sunken eyes like they’re in their late 40s. I’m happy to be losing the gut, but I didn't realize the trade-off was going to be looking like a shriveled version of myself. Are you guys doing anything to stop the sunken, aged look, or do we all just have to accept looking ten years older in exchange for being thin?
I have non-alcoholic fatty liver disease (NAFLD) and my doctor has been monitoring my liver enzymes since I started tirzepatide. I didn't think much of it until I read the SYNERGY-NASH trial results published last year .
The study looked at tirzepatide in people with biopsy-proven NASH (the more severe form of fatty liver) and significant fibrosis. After 52 weeks, 73% of patients achieved NASH resolution without worsening of fibrosis . That's not an improvement, that's a potential cure.
My own liver enzymes have dropped from elevated to completely normal. ALT went from 85 to 22. AST from 70 to 18. My hepatologist said she's never seen anything like it without a transplant.