Neutropenia and MCAS
Hi everyone.
I have neutrophils ranging around 1.3 to 1.9 10^9/L (reference range is 2-7.5 in UK). I came across some comments here (eg. https://www.reddit.com/r/MCAS/comments/19c5te5/is\_there\_any\_abnormal\_bloodwork/), and quite a few people appear to have neutropenia.
There doesn't appear to be any research on MCAS and neutropenia, however research shows that mast cells can consume neutrophils (named nexocytosis: https://www.cell.com/cell/fulltext/S0092-8674(24)00774-8). I wonder if mast cells can therefore draw substantial neutrophils from the blood and reduce the count? The study seems to suggest the number of neutrophils affected is small, but perhaps chronic mast cell activation can have an effect over time?
I'm curious if anyone knows more about this and if neutropenia is a common finding. It's odd that there appears to be no research since a WBC is a simple test to do.
I should mention I'm not diagnosed with MCAS, though I suspect it is possible due to response to fexofenadine, famotidine and quercetin, and symptoms including dysautonomia, brain fog, rhinitis, acid reflux and chemical sensitivities. I get some skin lesions but it's difficult to distinguish from eczema. There is a possibility IgE allergies are a cause (I have high total IgE) though my symptoms got worse after a virus suggesting increased mast cell sensitivity.
I should also mention my copper and caeruloplasmin is normal.