Running NAD+
Hey everyone,
I’m looking for some feedback on my current NAD+ protocol and whether my planned schedule is sustainable long-term.
For the past 10 days, I’ve been doing 60mg NAD+ injections daily (subcutaneous/IM). So far, I've handled the acute flush/side effects completely fine, but I know running a consecutive-day schedule this long is pushing past a standard loading phase.
My original plan was to keep running this either 5 days a week (Monday–Friday) or even 7 days a week continuously.
A few questions for those who have experience with long-term, high-frequency NAD+ cycles:
1 Is 5–7 days a week indefinitely too much? Am I going to hit a wall with receptor desensitization or diminishing returns? Or should I pivot to a standard 3x a week (M/W/F) maintenance routine now that my first 10 days are done?
2 Methylation Support: I know running this much NAD+ heavily drains the methyl pool. I haven't been supplementing with a methyl donor yet, but I'm planning to pick up some oral TMG (Trimethylglycine / Betaine Anhydrous) to take on injection days. What daily oral dose of TMG are you guys pairing with a \~60mg injection protocol?
3 Any specific brands of TMG you recommend, or things to look out for regarding mood/sleep changes when pushing a high-frequency
schedule like this?
Appreciate any insights or anecdotes from anyone who has run similar daily protocols!