Wife had massive progression on ipi nivo and then more progression on cabo nivo all in the span of three months....Anyone had similar and if so what in the world did you try next.
Wife has had ZERO success on all the heavy hitters....She is only 38....Now her lungs are absolutely flooded with mets and she started with ccrcc stage 4 grade 4 with an 11.2cm tumor on kidney and only 7 tiny mets in lungs.....Within 6 weeks of starting ipi nivo she had tons of progression and a 5.2cm tumor grow into her chest wall in just that 6 weeks and then 6 weeks later on cabo 40mg nivo ahe has innumerable mets in both lungs and another 4.2cm growth on the other lung.....She has had zero growth in her main tumor but absolutely zero shrinkage anywhere else.....We are at a loss and she ia currently in hospital....she does have vhl mutation but she is already anemic with a hemoglobin below 8 along with very low protein and fluid in her lung and abdomen....we are being seen at Duke....Because this has been so abnormally aggressive I asked for a biopsy on her lungs to make sure something else is not going on
I know Belzutifan with possibly Lenva could be an option if insurance approves but was wondering if anyone has any input with a similar terrible path to start with this massive of progression and if so did anything eventually work.....Starting to wonder if immunotherapy caused hyper progression or if she has something on top of the ccrcc....Any input as always is so much appreciated