RETA RECONSTITUTION
Question about Reta Reconstitution: 1.5 mL vs. 3 mL Bacteriostatic Water
Hi everyone! I have a question about reconstituting a 30 mg reta vial using bacteriostatic water (BAC water).
The instructions I received say to use 1 mL of BAC water per 10 mg of reta, meaning 3 mL of BAC water for a 30 mg vial.
I'm considering using 1.5 mL of BAC water instead of 3 mL because I use a 0.5 mL U-100 insulin syringe with a 31G × 6 mm needle, and drawing a smaller volume would be easier for me.
I already understand the dose conversion:
30 mg reta + 3 mL BAC water: 5 mg = 50 units.
30 mg reta + 1.5 mL BAC water: 5 mg = 25 units.
My question is: Is it safe or okay to use 1.5 mL of BAC water instead of the instructed 3 mL? Would using less BAC water affect the reta's stability, solubility, potency, or effectiveness, or would it simply make the solution more concentrated?
I'm happy with my current 5 mg dose and am not planning to increase it. I just want to understand whether changing the amount of BAC water would make any difference beyond the concentration and injection volume.
I'd appreciate your answers, especially from anyone with pharmaceutical knowledge. Thank you guys! 🙏