Mestinon/guanfacine/LDN/midrodrine and ivabradine?
I was recently diagnosed with POTS and hypermobility.
Current/previous meds:
Ivabradine: started at 2.5 mg and am now taking 7.5 mg in the morning and 5 mg in the evening. It helps keep my HR more controlled.
Guanfacine: most helpful medication so far. I take 1 mg in the evening. It seems to have reduced adrenaline dumps and helped with my sleep and exercise tolerance.
Mestinon: I started about a week ago and increased gradually. It seemed to help during the day with upright tolerance but I’m wondering whether it may be causing a kind rebound effect for me. Over the last 3-4 days, my sleep has become worse again and my overnight HRV has completely worsened. I stopped it yesterday and had one of my worst nights again, waking around 3 a.m. and being unable to fall back asleep.
I know this could also be other factors like heat etc but I stopped exercising the last three days and reduced load like crazy so I don’t get what is happening
Have you experienced anything similar with Mestinon?
A POTs specialist also mentioned to me yesterday midrodine and LDN /naltrexone as possible options, but I don’t know if I will tolerate them, especially with hypermobility and hyperPOTS. I feel my main issue is being hyper all the damn time :(
What do you think?