u/Firm-Crazy-9689

Zoloft**

What benefits can there be in taking it at night?

I've always been told to take it in the morning with breakfast.

I understand that they might do it at the beginning so that the effects of the start of treatment are perhaps lessened.

Knowing that the half-life of sertraline is 26 hours, during the day we would be feeling a decrease in its presence in the blood during the day...

I would like to know of cases where you have managed to get off sertraline, where it has remained stable for at least a year.

I would be very interested to know the withdrawal protocol, how long have you been on each dose?

how many months did you spend on each plateau during the retreat?

What have you felt throughout the process?

Did symptoms appear when you reached zero? How long did it take for them to go away?

Has anyone had experience with hydroxyzine and sertraline? Could it be a good rescue drug for withdrawal symptoms? I've read about it in several posts...

Anyone with experience using hydroxyzine and antidepressants, please write to me! Or even just for anxiety and panic attacks,

is it a good medication? Are single doses or a daily regimen effective? I'm primarily interested in it for the withdrawal of sertraline.

So, where do you think this is going to lead us, this business of training AI with underpaid labor?

Intellectual or computer work taken over by artificial intelligence, physical work taken over by robots...

It is true that robotics has helped us increase productivity, but always with our supervision and some human management.

I only see two options, and if you think it's going to be more complex, leave a comment, but I only see; one: go back to the countryside, losing privileges.And two, becoming cyborgs to compete with robots, but that could be atrocious... How many modifications can a monkey that uses intelligence for survival withstand? And I fear that this intelligence, if not used enough, will decline...

The arrows indicate the uncontrollable panic attacks.

I’ve been taking sertraline for several years and have now had two very difficult tapering attempts.

The first withdrawal was relatively abrupt and done under psychiatric supervision. Interestingly, the first ~3 months were actually very good, it was summer and I felt surprisingly well, with almost no withdrawal symptoms. Then, around day 120, things suddenly deteriorated, with severe symptoms, uncontrollable panic attacks and extreme tachycardia, over 200 bpm. I tried to control the attacks with clonazepam, but it wasn’t enough. Eventually, I had to reinstate sertraline and return to 100 mg...

The second attempt was much slower, but I did it on my own, reducing continuously by roughly 0.5% per day. At first this seemed to work quite well, but eventually I had another severe deterioration at 3.5 mg. Looking back, I wonder whether the continuous reductions, without proper stabilisation periods, may have been part of the problem despite each reduction being small.

I’m now back on 50 mg (47 days) and considerably more stable, and I’m considering a third attempt, this time with a psychiatrist. The idea would be to reduce much more slowly, using proper stabilisation plateaus and keeping each step to no more than roughly a 10% reduction in estimated SERT occupancy, rather than continuously reducing every day.

I was originally prescribed sertraline mainly to help me get off alprazolam. I was dependent on alprazolam at the time and would get severe panic attacks during withdrawal, so sertraline was introduced as part of that process. My goal now is ultimately to come off sertraline as well, as I did not start it because of a longstanding need for antidepressant treatment.

I’d really like to hear from people who have been through multiple failed attempts and eventually managed to come off successfully. Any advice or personal experiences would be greatly appreciated, especially from people with a difficult withdrawal history. Thanks to anyone who replies!