Do you prefer John being enhanced by the Super Soldier Serum or the Power Broker Augmentation process? Or would you prefer to see him with a different means of enhancement ?
I can definitely see John utilizing the Goblin Formula really well.
If he was bit by a radioactive spider, he'd definitely be more like Kaine than Peter Parker.
Gamma Radiation would probably be a game changer for him too.
Comment if you have anything else that might suit his character.