I have a question about Tesamorelin + Ipamorelin.
Hey everyone, I’m 43, male, and looking for some advice on my recent bloodwork after starting a tesamorelin/ipamorelin blend.
I started on August 24 at 1.3 mg total per dose, which was 1 mg tesamorelin and 300 mcg ipamorelin, Monday through Friday.
On September 28, I increased to 2 mg total per dose, still Monday through Friday with the same ratio. That works out to approximately 1.54 mg tesamorelin and 460 mcg ipamorelin. I’m self-administering without medical supervision.
My baseline labs from July 8, 2026:
IGF-1: 212 ng/mL
IGF-1 Z-score: +0.9
A1c: 5.6%
Fasting glucose: 94 mg/dL
Fasting insulin: 17.1 µIU/mL
My latest labs from October 5, 2026:
IGF-1: 376 ng/mL, above the lab’s reference range of 52 to 328
IGF-1 Z-score: +2.3, reference range −2.0 to +2.0
A1c: 5.4%
Fasting glucose: 101 mg/dL
So my IGF-1 went up about 77%, from 212 to 376. My A1c came down a little, but fasting glucose went from 94 to 101. These latest labs were taken one week after I increased the dose.
Has anyone had a similar jump in IGF-1 on this blend? I’m wondering whether to stay at 2 mg or go back down to 1.3 mg. Anything else I should be considering or asking about?
Any advice or similar experiences would be appreciated. Thanks!