u/Hot_Resort9777

Deadly complications during VLCDs
▲ 12 r/PSMF+1 crossposts

Deadly complications during VLCDs

I'm certain that we are all aware of the precautions in order to prevent possible physiological damages during very-low-calorie diets, like supplementing minerals (electrolytes), micro-nutrients and sufficient protein (if protein-sparing fast). Especially electrolyte-disorders through hypokalemia can cause fatal arrhythmia in combination with cardiac stress & extreme hypophagia. But I'm currently reading some papers discussing sudden death amongst obese dieters on VLCDs and these cases have never been fully clarified. Some of the deceased were monitored more or less actively, but changes in ECG were just ignored; some used unfortunate formulas with incomplete protein; majority of them was female; not every death was linked to the diet itself afterwards - there hasn't been a full explanation ever since, besides making changes to the diet, to make modern approaches/formulas/protocols safer. The only truth seemed to be that medical supervision is crucial.

What is your opinion on that matter? Many, especially in this forum, seem to undergo this procedure on their own without assistance & I couldn't find any recently recorded deaths despite the huge popularity of VLCDs.

https://pubmed.ncbi.nlm.nih.gov/6372663/

https://pubmed.ncbi.nlm.nih.gov/7223697/

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.60.6.1401

https://pubmed.ncbi.nlm.nih.gov/7275462/

https://www.mja.com.au/journal/2008/188/6/safe-year-long-use-very-low-calorie-diet-treatment-severe-obesity

https://www.nytimes.com/1977/12/28/archives/data-suggest-tie-between-15-deaths-and-liquid-diet.html

https://www.nytimes.com/1977/12/29/archives/doctor-says-reports-tying-deaths-to-liquid-protein-are-premature.html

https://www.washingtonpost.com/archive/politics/1977/12/24/doubts-on-protein-deaths/ec1b9e5a-c611-4ffd-916d-7d863f5feaaa/

u/Hot_Resort9777 — 8 days ago
▲ 10 r/PSMF+1 crossposts

Maximum body fat mobilization per day

I'm not certain whether this is the right subforum to thematize that subject, because it might be more advanced, but anyway. My current scientific knowledge pledged myself that lipolysis during (prolonged) fasting is highly generous due to low insulin levels/elevated GH-levels. That should make an beneficial impact on body composition, resulting in an muscle-sparing effect. There have been many confusions between contractile muscle tissue and fat-free mass, that asserted higher catabolisms, but these claims were unstable. Many articles describe a rate of gluconeogenesis around 15-20gP/24h. I'm aware of modified fasts & the fear of muscle loss, which exists amongst athletes, which are packed with extensive amount of muscle mass and low body fat. I'm not covering these guys, but the average healthy John Doe at 15-20 % BF. So, my current conception was, that true muscle loss amongst most people during even prolonged fasts was minimal, if done properly. But recently, I came across a study (I didn't read, shame on me) considering a limit on energy transfer from fat stores. That would change the game. If there's a specific caloric limitation, catabolism would make an heavy impact, especially during fasting. Many people commented on the study as nonsense or botched - not taking weight lifting, activity, exogenous "things" (pls don't ban me) into account, but there wasn't an consensus. Thus, I just thought about asking about your opinion on the matter, especially if experienced in prolonged fasting (with accurate metrics). Cheers.

-- Sorry, English is not my native language --

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u/Hot_Resort9777 — 19 days ago