u/Icy-Ear7110

Hello everyone. Im a caretaker for my mother suffering from stage 4 nsclc with no actionable mutations but pdl1 was 12 %. Having questions regarding other treatments.

My mom 59 was diagnosed with cancer stage 4 nsclc lung adenocarcinoma at the end of December right around new year. It was a random scan that led to the diagnosis. She had back pain near the shoulderblade on the left side which did not go away after pain meds and physiotherapy. Just to check we had done a MRI of the back muscles and they apparently mistakenly did an MRI of lung. Which showed certain nodules and had to be biopsied. The first biopsy showed no actionable result and had to be revised with VATS. After which it was concluded that it is NSCLC Adenocarcinoma with no actionable mutations and with pdl 1 of 12%. No distant metastasis. Till then my mom had no symptoms whatsoever. She is not a smoker and keeps herself really fit and healthy. No junk foods too. Her labs used to show a vit B12 level more than 1500 and she got it checked with cancer specialists, they couldn't find a reason at all. Now thinking back... Lung cancer would have been the reason why her B12 was so high. She started chemo + keytruda. Carboplatin+ pemetrexed+ pembrolizumab ---> was given for 4 cycles then in pet ct it showed only one avid lesion on the left lung near the apex, but it too had shrunken by around 30%. So on that note after the 4th cycle she was only on pemetrexed and pembrolizumab. After the 8th it showed no reduction and it remained stable. Which made us worry as to whether it will respond or not. Now she has been told to continue on pemetrexed pembrolizumab and Bevacizumab (newly started) for another 4cycles. My questions are as follows

  1. does Bevacizumab work ?

  2. are we going in the right direction?

  3. because of the spread of the lesions she is not a candidate for radiotherapy or so has the treating oncologist said ... Should we get a second opinion... If so then should we get it during this cycle or after it's finished?

  4. I am seeing so much of people online on Instagram and certain forums stating that febendazole and ivermectin helps and it makes them cancer free. Has anyone done it and come out the other side ?

Due to work reasons im not with my mother back in india and am in Europe. So I am not able to personally go around in india and ask for second opinions and testimonials regarding the treatment. That's why I am asking the good people of reddit. People in this subreddit have helped me a lot with going through my emotions and feelings. You guys deserve a heart felt thank you.

Any and all inputs are welcome and appreciated. Thank you

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u/Icy-Ear7110 — 3 days ago