u/Initial-Asparagus194

I have been on 2.5 mg oral dut with 5 mg fin for 4 months now. When I get on/off fin my scalp stops/starts itching like crazy within a week or so, it’s crazy how much different the itch is and that it only happens in a week, this I’ve experienced 4-5 times of getting on and off fin. This kept going (itch comes back and goes after getting on fin) despite 4 months of 2.5mg oral dut. Dut does literally nothing to me. I’ve been on mega dose for 4 months and if I drop the finasteride it’s as if 0 dht is being blocked (I’ve also back this up with blood tests). I take Australian expensive proper dutasteride gel capsules. Wtf is going on why does it not work at all??

Trying to understand some similarities between us

Keen to get some feedback/ thoughts

I’ve come up with this by large part as a result of my own experience/ the presentation of my hairloss, let me know if you guys have similar symptoms or if some things are not the same.

In ophiasis alopecia the nape and sides are the only things to go, fundamentally this is because for different reasons, those follicles are more vulnerable to cytokine attacks. With aga comes a different mix of the products in sebum, a study tracking scalp microbiomes and lipid profiles (PMC8536999) discovered that sebum triglyceride and palmitic acid contents are significantly higher in the AGA group compared to healthy controls. These are the precursors for cytokines. My theory is that the reason retrograde happens is because the follicles on the sides and nape are for us more vulnerable to these cytokines and respond very differently then for example on the top of our scalp. So the difference in density between the sides and the top can be explained by greater vulnerability to cytokines. As far as I can tell, there is no reason why in a few highly vulnerable people, this response to cytokines can be much much worse then for most people and if we can fix that, we can fix our retrograde. This is where an amazing new product: topical roflumilast comes in. This shuts down inflammation ie cytokine attacks. I see it possible that this could be the reason for retrograde. I personally have a crazy itch, an itch that improves on finasteride and an itch that goes away after a shampoo of the scalp (which shampoo doesn’t matter). All of these fit with my little hypothesis.

Let me know what you guys think!

After you clean your scalp, with any shampoo, does the itch go away for a bit?

I have been interested in entrepreneurship since I was 10. I spent my lunch times sitting with my friend coming up with a nerf gun version of paintball business plan. I have started half a dozen little entrepreneurial ventures since I was a kid, first company at 15, now 20 I do 45k a month revenue passive. My point is I really wanna do this, but properly though.

I have not worked for 3+ years in a propper business, understanding how different departments work, when and how you hire people, (further then this i dont even know what i dont know). Mentally i can see the path to getting an ecom brand to 3mil or something but i cant visualise the path to a 50mil, 300 mil proper company. Everything in excess of a 3 mil ecom brand seems like magic to me.

My question is, how do you break through that? Do you just come up with a magical products/service thats so in demand you get slack for poor marketing/operational ability and ultimately just figure it out, do you have to work for someone else to understand the pieces to to growing a 300 mil company, do you just do it and have a tiny chance you learn along the way, do you need a mentor, etc.

Basically what I’m trying to ask is what steps do i need to take to break through my current understanding/limitations, maybe from someone whos made it to the other side?

Appreciate advice :)

I have been interested in entrepreneurship since I was 10. I spent my lunch times sitting with my friend coming up with a nerf gun version of paintball business plan. I have started half a dozen little entrepreneurial ventures since I was a kid, first company at 15, now 20 I do 45k a month revenue passive. My point is I really wanna do this, but properly though.

I have not worked for 3+ years in a propper business, understanding how different departments work, when and how you hire people, (further then this i dont even know what i dont know). Mentally i can see the path to getting an ecom brand to 3mil or something but i cant visualise the path to a 50mil, 300 mil proper company. Everything in excess of a 3 mil ecom brand seems like magic to me.

My question is, how do you break through that? Do you just come up with a magical products/service thats so in demand you get slack for poor marketing/operational ability and ultimately just figure it out, do you have to work for someone else to understand the pieces to to growing a 300 mil company, do you just do it and have a tiny chance you learn along the way, do you need a mentor, etc.

Basically what I’m trying to ask is what steps do i need to take to break through my current understanding/limitations, maybe from someone whos made it to the other side?

Appreciate advice :)