r/HairlossResearch

Waiting for a MPB cure that doesn’t cause nasty sides feels like…

27 years I’ve been fighting hairloss and I’ve tried everything, if it works it has sides. I’m 52, 4 FUE HTs in 16 years now and still there’s NOTHING.

u/action-jaxxon — 8 hours ago
▲ 2 r/HairlossResearch+1 crossposts

Avoiding gyno on fin when you are prone

Hello everyone,

I am a 28 yo male with mild diffuse thinning but significant thinning on the crown. I have pre-existing gyno from puberty and was always worried about making it worth with finasteride but the thinning started getting worse so I took the plunge 8 months ago and used 1mg oral finasteride + 5% topical minoxidil daily. One month in and I started feeling breast/nipple tenderness and pain for a week and I stopped.

The pain persisted for the next 7 months despite stopping fin (though it was on and off). Gyno looks like it's gotten slightly worse although it's hard to be 100% sure since I already had a pre-existing case (confidence level is 80%+). I tried finasteride again 2 weeks ago but stopped after a week again due to immediate nipple/breast pain and sensitivity. GP gave me a referral to get a mammogram to actually track the size but unfortunately I have not done one before so I have no baseline, I suppose I could just get the mammogram, try oral finasterida again, and get another to see if there is any actual growth.

I am hoping to try out 0.025% topical finasteride as there is this study showing it has less serum DHT suppression than 1mg oral but similar scalp DHT suppression: https://pubmed.ncbi.nlm.nih.gov/34634163/. Has anyone else tried this? And has anyone who is prone to gynecomastia like myself had any success with finding a hairloss prevention protocol that does not make the gyno worse? RU58841 seemed promising but it's really hard to get it consistently where I live (Sydney, Australia)

FYI: My total T is 600ng/dl and estradiol is 22 pg/ml (measured 1 month ago). Unfortunately never got my free T/E2/SHBG tested as GP did not want to.

u/Good_Ability6765 — 11 hours ago

Anyone get sides from finasteride topical

Used topical fin for abit over a month for sides stopped using, mental sides improved but ed still hasn’t improved and morning wood. Abit worried libido also down still but has minor improvement

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u/Long-Breadfruit7991 — 13 hours ago

ADVICE: Been on Finasteride for 10+ Years, Have Gyno Issue, Wondering About Next Steps

Hiya, I'll try to keep my story short.

I had a bit of Gyno during puberty that never went away. I'm a tall and slim guy and on the most part it didn't bother me, and it didn't feel too noticeable. I started taking Finasteride in my mid to late 20's after an ex of mine (who was a hairdresser) suggested it when I was concerned about a receding hairline. I started taking it daily and have done ever since. After the first few years there were no side effects, however I did start noticing a small increase in the gyno size, I had put it down to a little bit of weight gain at the time.

Fast-forward to now, I'm 38 years old, UK. I'm still slim and regularly workout, but I still have the breast tissue, which hasn't gone down, but does feel a bit bigger. On one had I try to embrace my body, it's the body I was born with and I should be proud of it, however, I do feel a great sense of embarrassment. I hate taking my top off around people that I know or on holiday, and I have to think carefully about what I wear because I "don't want my boobs to show", a phrase that my partner hears on a daily basis. It really affects how I view myself and I feel very ashamed of them. I know it's because of the puberty gyno and finasteride, and I would consider stopping finasteride if I also didn't want to keep the amount of hair I currently am retaining. Finasteride has really worked with my hair. I have a brother 2 years older than me and I use him as a comparison, he has been rapidly losing his hair and I don't want to look like him, I don't mean that in a harsh way, but I'm very happy with my hair, it feels like a huge part of my identity.

I have considered gyno surgery, I am still considering it, but I really want that to be the last resort. I haven't spoken to my GP about this due to embarrassment, but I wonder if I should talk to them and see if I can get some other medication to maybe balance out the hormones. Will it even do anything if I've been taking Finasteride for 10+ years? At what point do I give up and just accept hair loss? Do I just continue embracing my gyno, I've had it since a teenager, even before finasteride.

Any comments, suggestion or advice will help. My 'boobs' affect my mental health and cause me to put restrictions on how I live my life.

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u/Possible_Patient8409 — 10 hours ago

Is anyone here using topical spironolactone?

Does it work? The handful of studies available suggest it does, without any systemic side effects. Am I missing something? There are a couple of telemed companies here in the UK that prescribe it to males. Don’t know whether to give it a shot.

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u/JamesG0986 — 11 hours ago
▲ 14 r/HairlossResearch+1 crossposts

Hair System Before a Hair Transplant – Good Idea or Bad Idea?

Hey everyone! I’m thinking about getting a hair system (a wig) before I commit to a hair transplant. My plan is to do the transplant eventually, but I want to try the wig first to see how I’d look and feel. While wearing the wig during this time, I’m also considering treating my hair. I have a question—for those who used clip-on hair systems (attached on the sides)—did it affect your natural hair? Did you notice thinning or breakage? I really want to give it a go before the transplant, and I hope to use this time to care for my hair as well. I’d love to hear your honest experiences and advice. Thanks a lot!

u/Hairinvestegetor — 1 day ago

Dutasteride isn’t blocking any DHT

I have been on 2.5 mg oral dut with 5 mg fin for 4 months now. When I get on/off fin my scalp stops/starts itching like crazy within a week or so, it’s crazy how much different the itch is and that it only happens in a week, this I’ve experienced 4-5 times of getting on and off fin. This kept going (itch comes back and goes after getting on fin) despite 4 months of 2.5mg oral dut. Dut does literally nothing to me. I’ve been on mega dose for 4 months and if I drop the finasteride it’s as if 0 dht is being blocked (I’ve also back this up with blood tests). I take Australian expensive proper dutasteride gel capsules. Wtf is going on why does it not work at all??

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RAW Ahk-cu / ghk-cu

Hi ,

I'm into pur chasing raw Ahk-cu , topical for hair growth and ghk-cu, found many on Alibaba however I couldn't know which one is a legit and pure product. Did any one of you bu y / try it or have trusted source from china or Europe?I'd really appreciate it.

My hair used to be long and thick, but every year I noticed a little bit of hair loss. Last year I started using Mast, and it absolutely wrecked my hair. I’m no longer using anything, but my hair is still falling out. It's become noticeably thinner at the front, while the back and sides are still thick.

Apart from the peptides mentioned above, has anyone tried something topical that actually works to regrow and thicken hair? I'm looking for recommendations from people with real experience.

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u/Life_Doubt_680 — 1 day ago

Hair loss has somehow become my most expensive free hobby

Im 29 and I swear Ive spent more time researching hair loss than some of my actual hobbies. I'll watch a YouTube video read a few Reddit threads, compare before and after pictures, look up ingredients I cant pronounce and suddenly its midnight.The funny part is I haven't even spent that much money. Most of my time has gone into researching instead of doing anything. Every treatment has people saying it changed their life and another group saying it was a complete waste of time. Then someone else says you started too late or too early or used the wrong routine.

I work in IT so my brain wants a clear answer before I commit to something, but hair loss just doesnt work like that. The worst part is realizing Ive spent another saturday reading opinions from strangers instead of going outside. I dont even know if Im looking for the best treatment anymore or just trying to convince myself I picked the right one.Anyone else get stuck in the research loop more than the hair loss itself?

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u/DutyDefiant7041 — 2 days ago

Rate my stack

Hi all, 22M with thinning and shedding consistent with male pattern baldness since 16-17. My dad’s grandfather and my dad’s brothers all suffer from moderate to severe MPB, and my mother also has thinning and dropping hair. I am fighting a genetic battle and balding at this age has been a major insecurity of mine.

My stack:

Orals:
-2.5mg oral Minoxidil ED
-1mg Finasteride ED

Topicals:
-Self made AHK-Cu 1% and GHK-Cu 1% solution (made with sterile water, propylene glycol, vegetable glycerin and Liquid Germall Plus as a preservative)
-The Ordinary Hair serum (A bunch of hair regrowth peptides and caffeine)
-Ketoconazole 2% shampoo (twice a week)

Supplements:
-Vitamin D3 5000IU
-Vitamin K2 125mcg
-Zinc Glycinate 20mg
-Magnesium Glycinate 300mg

Protocols/Habits:
-Microneedling once a week (no topicals for the following 24 hours)
-Scalp massages
-Stress/cortisol reduction with breathing exercises

Thank you!

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u/EvenGate2742 — 2 days ago

The Finasteride generation

In an age of omnipresent virtual comparison, balding is a condition that many men would not want to endure for anything in the world - despite all the studies suggesting that such a radical intervention can have such a significant impact on one of the most characteristic male hormones, affecting presence, emotional well-being, libido and even cognitive abilities.

Given the increasing prevalence of finasteride (from celebrities, politicians and high achievers right down to the average Joe), surely a whole generation of men must be emerging who have to face life with a (sometimes conscious, sometimes less conscious, sometimes painstakingly ignored) disadvantage, less able to survive, perform and exist in a world where even DHT must have a raison d’être, however emergent and subtle it may be.

My question are: Are we going to be faced with a pandemic of ‘finasteride men’? Will there be a statistically measurable decline in performance in our society - a dip in performance - and can bald(-ing) men in particular benefit from this?

Or even asked provocatively: Will a full head of hair in progressed age soon be associated with this decline in performance, whilst a bald head will be seen as a sign of high competence and masculinity?

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u/FirmConcentrate2962 — 4 days ago
▲ 9 r/HairlossResearch+1 crossposts

My hair is getting thinner on dutasteride.

Hi everyone, as the title says, my hair keeps getting thinner on dutasteride and i don't understand why.

At the beginning i was suffering from a very very early case of male pattern baldness, like noorwood 1 at most, but still balding.

So I decided to start treatment asp & for 10.5 months i've been on 2mg finasteride and 2.5mg oral minoxidil everyday. I was shedding heavily on this protocol, but my hair has never looked thinner and it got thiccer and fuller overall. After 10.5 months My hair was so full and my hairloss completely stabilized.

Exactly 3.5 months ago i decided to switch from 2mg finasteride to 1.5mg dutasteride, because i wanted to maximize results. Around 1.5-2 months in and till now, I strated noticing that my hairline has gotten really thin, like I can see the scalp where my hairline is and it has never been like that before.

I wonder if anyone is familiar with similar cases?

And what can I do? Or check?

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u/Mobile-Conference-60 — 5 days ago

My 1.5-year journey: Transitioning from Finasteride/Topical to Dutasteride + Oral Minoxidil (5mg)

Hi everyone,
I wanted to share my hair loss journey over the past 18 months. It’s been a long process of adjusting my protocol to find what works best for my AGA. Here is my timeline:
My Timeline & Protocol:
Jan 2025 – Oct 2025: Started with 1mg Finasteride daily + Topical Minoxidil.
Oct 2025 – Feb 2026: Switched to 0.5mg Dutasteride daily.
Feb 2026 – May 2026: Added 2.5mg Oral Minoxidil to the regimen.
May 2026 – Present: Dropped topical minoxidil entirely and increased my Oral Minoxidil dosage to 5mg daily.
Current Status & Observations:
The transition to 5mg of oral minoxidil has definitely triggered a significant shed. While it’s stressful, I’ve noticed a lot of vellus/baby hairs popping up, especially along my hairline, which gives me hope. Compared to where I started in early 2025, my overall density is better, but the progress is currently in a "fluctuating" phase due to the recent increase in dosage.
Questions for the community:
1.For those who switched to 5mg Oral Minoxidil, how long did it take for you to see stabilization after the initial shed?

2.What has been your experience with vellus hair maturation while on a high-dose oral minoxidil protocol?

3.I am interested in hearing about your long-term timelines with this dosage—when did you notice the peak visual density improvements?

I’m curious if anyone else has gone through a similar transition from topical/lower dose oral to 5mg. Any feedback or shared experiences would be greatly appreciated.

u/katharsisjp — 5 days ago
▲ 34 r/HairlossResearch+1 crossposts

Hi, I came across an interesting study:

"Androgen levels and apoptosis in the testis during postnatal development of finasteride-treated male rat offspring"

https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/41940

This study investigates how treating adult male rats with finasteride, impacts the reproductive health and development of their male offspring.

The authors observed reduced litter sizes and an unusual shift toward more female births among the treated group's descendants. Analysis of the male offspring revealed altered levels of testosterone and dihydrotestosterone in both the blood and testicular tissue. Furthermore, the researchers found that the natural process of germ cell apoptosis, which is vital for healthy sperm production, was disrupted during the first wave of maturation.

Ultimately, the study suggests that finasteride may act as an endocrine disruptor with transgenerational effects, potentially impairing the fertility and hormonal balance of future generations.

I would like to hear your opinions on this study. Concerns about the health of my future children are actually my biggest barrier to taking finasteride.

I would also be interested in hearing from older users who took finasteride many years ago and went on to have male children who are now adults—have you noticed any reproductive health issues in your sons?

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u/Leon307 — 6 days ago

Sourcing topical vitamin D

I’m intrigued with all the talk about topical vitamin D enough to try to add to my stack, I figure the downside is very low so why not try?

I was wondering about sourcing. In most countries it requires a prescription which I think would be difficult to obtain since it is off label use for androgenic allopecia, it is mostly prescribed for psoriasis.

I was wondering if anyone had successful sources? I’ve heard rather mixed things about indamart where they don’t use discrete packaging for customs.

There are also two forms: calcipotriol and calcitriol. I would probably lean towards the former since it is engineered to limit systemic absorption.

Thanks for any input! Also I’m based in East Asia in case that affects shopping.

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u/DR-b11 — 5 days ago

Saw palmetto….again 😅

Has anyone here tried the actual saw palmetto standardised extract (320 mg with at least 85% fatty acids), either orally or topically, and still lost ground? The dried extracts/powders nearly always incorporated into ‘natural’ hair loss products are a total scam because they don’t contain the precise components shown in studies to inhibit 5 alpha reductase I/II. Has anyone got any thoughts on this? I’m just curious.

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u/JamesG0986 — 6 days ago

Jxl069-3hp Update

Hey guys, I want to update that I have stoped using this product. The shedding just got so intense that I started to get insecure about going outside and I just had to pull it. Not long after I stopped the shedding stopped as well. I dont know if it would have settled down on its own with time but I had given it my best shot at hanging in there. Maybe Ill give it another go some day but right now I just want my density back lol. For now, Ive added RU85541 and topical estriol and will be saving up for a transplant.

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u/gtcyorktown — 6 days ago

Farmacia andorra stopped shipping to canada

I’ve been using 0.1% alpha estradiol shipped from that pharmacy for years now, but they recently just stopped shipping to Canada and I don’t wanna stop treatment. Does anyone know of any alternatives they’re in Spain

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u/No-Shirt-596 — 5 days ago