PCOS has now been medically accepted as metabolic syndrome driven. What does this mean for men with hair loss?
Recently the medical world has finally accepted the fact that PCOS is driven by being metabolically syndromatic. What does this mean for men with hair loss? Everything!!
I concluded years ago that Androgen alopecia men have the same hormonal pattern and distress signal as PCOS women. So what do they have in common? Both of them met the requirements for metabolic syndrome. Or any of its disease forms like fatty liver disease, irritable bowel syndrome, insulin resistance and diabetes. This means hair loss isn't "genetic" but a form of chronic inflammation that can affect you even at birth.
Since Mets itself can be passed down from parent to child. That means the coin "androgenetic" from the 90's was used to describe a phenomenon that we have yet connected the dots on. Mets... Being systemically passed down. And not prevented when you grow up. That is what causes hair loss in people. And especially in Westernized diets. Which has the highest metabolic diseases in the world. It literally stores fat into your liver causing you to become insulin resistant. And once your liver becomes inflamed... You lose hair!
How? The wnt/b catenin pathway is the main central hair matrix without it we do not grow hair period. Where is it signalling? The liver. So your liver has to be in good health in order to have good hair! Of course I am simplifying it. As the wnt/b catenin becomes down stream by nfk inflammatory pathways it up regulates tgf1b and dgkk1fp(I think) and interleukin 6 which down regulates testosterone and upregulation cortisol which then UP REGULATES DHT TO COUNTER ACT THE INFLAMMATION.
So why does hair go first? Your hair is glucose dependent. When you become insulin resistant the independent transport pathway for glucose becomes compromised preserving nutrients for other functions. Eventually your turnover rate becomes damaged from lack of supplies. Causing hair loss and skin damage.
So... Now the question is can mets be beaten? yes. As all forms of metabolic disease has shown remission and much promises in rejuvenation. Can hair grow back from this? people taking zepbound notice an increase in hair density when they drop their dosage and or when they put their diabetes in redmission https://pmc.ncbi.nlm.nih.gov/articles/PMC11318540/
This was possible because my running hypothesis is that as you become more insulin sensitive your metabolic profile returns to normal and you slowly stabilize. Ultimately returning from survival to recovering and into maintenance. There is a way brothers 🤙 hair loss is a disease and often a symptoms of a underlying disease especially if you're in your 20's and younger. Hence why "early onset" exist. Men shouldn't be balding until their late 40's and 50's anything earlier is a disease.
So my conclusion? people are not meant to lose hair. And when they do it is not healthy and a sign of illness. Accepting it as nothing less than "cosmetic" is undermining the complications that are causing not only your looks, quality of life, but your over all health. It is a silent killer. As insulin resistance alone is a sole driver to heart disease and pads ultimately leading early cardiactic arrest before being diagnosed.
Take your health seriously
Sources:
PCOS connection to androgenetic alopecia
https://pubmed.ncbi.nlm.nih.gov/27304785/
Wnt/b catenin pathway and it connection to liver health
https://pmc.ncbi.nlm.nih.gov/articles/PMC7404278/
Telogen effluvium and how it's relationship with diet and hormonal health
https://www.ncbi.nlm.nih.gov/books/NBK430848/
Cardiovascular risk and insulin resistance
https://www.sciencedirect.com/science/article/abs/pii/S1871402119300785